Sentences with phrase «death pathway»

Likewise, unregulated growth, abnormal cell division, and defective cell death pathways are hallmark features of tumors.

When death pathways slow down in cells that are normally programmed to die, cancer results.

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

«And cell - to - cell transmission of HIV is required for activation of the main HIV death pathway.»

«Same cell death pathway involved in three forms of blindness, study finds.»

«The TRAIL biochemical cell death pathway naturally lends itself as a drug target to restore anti-tumor immunity.»

Previous research from the Greene laboratory revealed that the main cause of cell death in HIV involves a programmed cell death pathway called pyroptosis, where the cells commit a particularly fiery form of suicide in self - defense to prevent the spread of the virus.

For example, if we had restricted our research to blood - derived cells, we would have missed primary cell death pathway operating during HIV infection.»

Conversely, when death pathways become overactive in cells that are programmed to survive, degenerative disease occurs.

What is the effect of the HIV - 2 accessory protein Vpx on HIV infectivity and the cell death pathway in lymphoid CD4 T cells?

Hear how the rewiring of cell death pathways can sensitize cells to traditional chemotherapy agents.

«Cell - to - cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell - death pathway.»

«By preventing cell - to - cell transmission, we may able to block the death pathway and stop the progression from HIV infection to AIDS.»

In the new study, published in Cell Reports, it was revealed that this death pathway is only activated through cell - to - cell transmission of HIV, not from infection by free - floating viral particles.

«The virus evokes a response in the infected cell that activates a pre-programmed cell death pathway,» said Stanley Lemon, M.D., one of the study's authors and a professor of medicine at UNC's School of Medicine and UNC's Institute for Global Health & Infectious Diseases.

Scientists from the University of Helsinki, Finland have found that even a short - term shortage of ATP supply can be fatal for cancer cells because activation of a mitochondria - addressed cell death pathway.

«Immune 1 -2-3 punch against parasites reveals potentially ancient cell death pathway: «Microptosis,» which resembles programmed cell death in animal cells, could present an antimicrobial drug development opportunity.»

Kanneganti emphasized that their discoveries have fundamental importance, because they identify a key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death pathways.

Further experiments revealed that ZBP1 was, indeed, a «master assassin» in the cell, responsible for triggering three separate cell death pathways.

Minocycline, a synthetic tetracycline - based antibiotic, has shown only limited success as an anti-cancer agent because it promotes the expression of pro-survival Bcl - 2 proteins and, subsequently, can lead to inhibition of caspase - 3 and caspase - 9 activation downstream in the cell death pathway.

«Basically it is a mutation that makes potential stem cells, or precursor cells, susceptible to apoptotic cell death pathways.

Then, when the researchers gave the mice a drug, the death pathway would be activated in all senescent cells.

Fleming researchers uncovered a molecular interplay between survival and death pathways in synovial fibroblasts mediating modelled Rheumatoid Arthritis.

Our research aims to continuously elucidate the caspase -2-mediated proinflammatory cell death pathway and its biological effect on microbial pathogenesis and protective immunity against brucellosis and other diseases.

«It turns out that blood CD4 + T cells are entirely resistant to this death pathway because they are too rested,» he said.

Remarkably, blood CD4 T cells are resistant to this death pathway, in part because the cells are in a deeper state of rest, meaning the virus is unable to infect them completely, which prevents the onset of the chain of events that leads to pyroptosis.

Importantly, the researchers used primary human lymphoid tissues, such as tonsil and spleen to uncover this death pathway.

And cells also have a «death pathway» for life termination that is also signaled.

Thus, blood cells can become sensitive to this death pathway if they come into contact with lymphoid cells, as would occur when blood CD4 T cells traffic into lymphoid tissues.

We're looking for a way to selectively switch on the death pathway for the cancerous cells but not the healthy cells.»

This program contains a number of proteolytic steps that are essential for efficient execution of the death pathway.

Using the techniques of protein chemistry, enzymology, crystallography, and recombinant DNA methodologies, we analyze the basic mechanism utilized by caspases to promote cell death pathways, and the mechanisms and specificity of the natural inhibitors that control them.

Liver disease has been of central importance with aging and programmed cell death pathways.

DOI: 10.4236 / abb.2012.326091 6,595 Downloads 10,607 Views Citations This article belongs to the Special Issue on Cell Death Pathways