Sentences with word «dedifferentiation»

These results provide further evidence of dedifferentiation of specific and general AM retrieval with age.

Previous work has found evidence for age - related neural dedifferentiation in visual cortex: Neural activation patterns in response to different visual stimuli are less distinctive in older compared with younger adults.

Methods: Here we model human β - cell dedifferentiation using growth factor stimulation in the human β - cell line, EndoC - βH1, and human pancreatic islets.

They further indicate that neural dedifferentiation is multifaceted, and likely can not be captured by a single neural index.

Hypoxia - induced dedifferentiation of tumor cells — a mechanism behind heterogeneity and aggressiveness of solid tumors

This is not to say that stem cells are not necessary to the process, however, because the cellular dedifferentiation process in urodeles is often presented as a means to locally generate pluripotent cells (perhaps stem cells or cells very similar to them).

The same fraction causes dedifferentiation of tissues of mesodermal origin, such as muscle and cartilage.

An efficient initial RPE differentiation protocol is essential for the production of cells for use in any therapeutic application since repeated passaging of RPE results in phenotypical and morphological changes associated with dedifferentiation [36], [37].

Second, specialized cells can undo their training — a process known as dedifferentiation — and assume a more pliable form that can replicate and later respecialize to reconstruct a missing part.

According to Spradling, these cells «likely arise by dedifferentiation in culture,» and «the same safety and reliability concerns would apply as to any laboratory - generated cell type that lacks a normal counterpart» in the body.

To test for age - related dedifferentiation in neural representations we combined univariate analyses with an encoding - retrieval pattern similarity (ERS) analysis in young and older adults to compare the overlap in neural representations between retrieval lures and their respective targets at encoding.

We were able to use pharmaceuticals to induce cell self - eating effects and stimulate dedifferentiation though not as effectively as 3D culture, so we need to do more work on this.

E1A is the sole oncogene capable of overcoming the stringent proliferative block connected with terminal differentiation, likely due to E1A - induced mimicry of important proliferation and dedifferentiation pathways, which are prime candidates for cancer pathways (24).

In some forms of cancer, such as melanoma, specialized cells can even go through what is called dedifferentiation and be converted back from specialized cells to cancer stem cells (2).

«What we're doing is inducing dedifferentiation,» Mani says.

Franziska Knopf (Weidinger, TUD)-- «Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin» (2011)

When President Bush's stem cell policy first came out, I wondered why scientists didn't try to isolate factors that cause dedifferentiation, instead of complaining about the policy.

The analysis also identified molecules whose expression was associated with dedifferentiation (loss of differentiated phenotype) for some cancer types.

Cells in newts can change in response to injury — a process known as dedifferentiation.

Dedifferentiation in the visual cortex: An fMRI investigation of individual differences in older adults

Dedifferentiation is a process by which specialized cells regress to a more basic, less specific form.

«The next stage is to find out more about the dedifferentiation process so that we can find the right treatment to encourage tissue repair in the damaged joint.

Metaplastic cells in the stomach arise, independently of stem cells, via dedifferentiation or transdifferentiation of chief cells.

Conclusions: We thus developed an FGF2 - induced model of human β - cell dedifferentiation, identified new markers of dedifferentiation, and found evidence for increased pancreatic FGF2, FGFR1, and β - cell dedifferentiation in T2D.

Objective: Dedifferentiation could explain reduced functional pancreatic β - cell mass in type 2 diabetes (T2D).

FGF2 - induced dedifferentiation was time - and dose - dependent and reversible upon wash - out.

In this brief discussion, I will give an overview of the different ways in which the concept of dedifferentiation is applied in the cognitive neuroscience of aging, drawing on the prior presentations for examples.

Together, the presentations and subsequent discussion will highlight the importance of neural dedifferentiation to the understanding of age - related differences in cognitive performance, link the phenomenon to broader notions of dedifferentiation current in the cognitive aging literature, and identify important avenues for future research.

The right amount of current, measured at the site in question (and not necessarily on the surface of the skin), with the right electrodes (silver in particular) will accelerate healing, kill bacteria, and may alter a cell's morphology to the point of dedifferentiation, including cancer cells.

Like any institution, monogamy implies a degree of dedifferentiation.

Sawing, the first piece one sees upon entering the exhibition, comes off as a bulky scatter piece, vaguely indebted to the dedifferentiation pieces of Barry Le Va and Robert Morris.