The US Food and Drug Administration has noted a higher - than - expected rate of suicide attempts in open - label extensions of controlled trials
of duloxetine for stress urinary incontinence.
A Randomized, Placebo - Controlled Study of
Duloxetine for the Treatment of Children and Adolescents With Generalized Anxiety Disorder Journal of the American Academy of Child & Adolescent Psychiatry: April 2015 - Volume 54 - Issue 4 - pp 283 - 293
Commonly prescribed antidepressants
include duloxetine (Cymbalta), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft) and venlafaxine (Effexor).
Harms potentially related to suicidality and violence were 4 - 5 times more common
with duloxetine than with a placebo.
Researchers found moderate evidence that the
antidepressants duloxetine and venlaxine, which act as serotonin - norepinephrine reuptake inhibitors, were effective in reducing neuropathy - related pain.
In this step, scientists
compare duloxetine to drugs on the market and attempt to identify the correct dosage.
The FDA recommends against approval of
duloxetine because of violations at Eli Lilly's Indianapolis plant, where the drug would be manufactured.
The FDA reviews more liver health data and
approves duloxetine for depression and diabetic neuropathy (pain), based on another set of clinical trials.
One of their molecules becomes known
as duloxetine, later branded Cymbalta.
In a 2004 study of 367 depressed patients, for instance, they found that
daily duloxetine doses of 40 and 80 milligrams offered more relief than a 20 - mg daily dose of paroxetine (Paxil).
Although they found that
duloxetine did lessen the frequency of incontinence, they also observed adverse effects associated with the drug.
Other side - effects of Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
like Duloxetine (Cymbalta) and Venlafaxine (Effexor) have potential side - effects like abdominal pain, itching, rash, dry mouth, dizziness, constipation, drowsiness, headache, loss of weight, loss of sexual desire, weakness, and increased sweating and flushing.
Additionally, we hypothesise that
duloxetine induces functional brain changes in emotional regulatory networks.
Prescription drugs that specifically treat fibromyalgia
include duloxetine (Cymbalta), milnacipran (Savella), and pregabalin (Lyrica).
In a 2002 study, for example, 267 depressed adults took either
duloxetine or a placebo for nine weeks.
Nemeroff has consulted for Eli Lilly, which makes one of the drugs being tested,
duloxetine, but his recent income has fallen below a $ 10,000 annual reporting threshold.
Duloxetine, a drug approved in Canada, the US and Europe to treat major depression, is approved in Europe to treat stress urinary incontinence — involuntary leakage of urine during exertion, sneezing or coughing — that affects an estimated 1 in 10 women.
A new study indicates that the benefits of
duloxetine, a drug used in Europe to treat stress incontinence in women, do not outweigh the harms.
«Given the uncertainty as to whether
duloxetine leads to clinically significant improvement in quality of life... we question the rationale for using duloxetine for stress urinary incontinence,» writes Emma Maund, lead author and researcher at the Nordic Cochrane Centre, with coauthors.
Three drugs —
duloxetine, pregabalin and milnacipran — have been FDA - approved to treat the disorder, but that's not your only recourse.
Next Page: Cymbalta [pagebreak] Cymbalta How it works: Approved in 2008 for use in fibromyalgia (and previously approved for diabetic retinopathy and depression), Cymbalta (
duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI)-- a type of antidepressant that raises the levels of the neurotransmitters serotonin and norepinephrine in the brain and body.
The 12 drugs included bupropion, citalopram,
duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, mirtazapine, paroxetine, reboxetine, sertraline, and venlafaxine.
Duloxetine - induced changes in brain activation differ between responders and non-responders.