Sentences with phrase «endocrine cells»
"Endocrine cells" are cells in our bodies that produce and release hormones, which are important chemical messengers that control various functions and activities in our body. Full definition
If the product performs as expected it will provide patients with a replacement for the pancreatic endocrine cells lost as a result of the disease.
viacyte.com
Although the main function of gut endocrine cells is to regulate digestion, the Duke researchers found these cells also have nerve - like properties.
While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.
In 2008, he transformed exocrine cells in the pancreas, which produce enzymes to help digest food, into insulin - producing endocrine cells in a mouse.
PEC - 01 pancreatic progenitor cells are manufactured from pluripotent stem cells and are designed to further differentiate and mature after implantation, not only to fully functioning insulin - producing beta cells, but also to the other endocrine cell types that make up the normal healthy human pancreatic islet.
When implanted under the skin, the PEC - 01 cells are designed to mature and further differentiate into insulin - producing beta and other endocrine cells that regulate blood glucose in a manner similar or identical to the islets that normally comprise the endocrine pancreas.
Mouse Pancreas Tissue Slice Culture Facilitates Long - Term Studies of Exocrine and Endocrine Cell Physiology in situ.
At the end of a meal, specialized endocrine cells in the wall of the small intestine release other hormones (like cholecystokinin, glucagon - like peptide - 1, and oxyntomodulin) that signal satiation.
Liddle and colleagues plan to gather and examine the gut endocrine cells from people with Parkinson's to see if they contain misfolded or otherwise abnormal alpha - synuclein.
Duke University researchers have identified a potential new mechanism in both mice and human endocrine cells that populate the small intestines.
Rather than using hormones to communicate indirectly with the nervous system, these gut endocrine cells physically connect to nerves, providing a pathway to communicate with the brain, Liddle said.
Many things are being secreted, which the brain sort of modulates, like the defensins from Paneth cells, there are many endocrine cells, serotonin cells in the gut, enterochromaffin cells, which are under autonomic control, so that we now know that serotonin, as well as norepinephrine, can, under stress for example, increase in the lumen of the gut.
As the PEC - 01 pancreatic progenitor cells represent a cell type that is present in a developing embryo, they are designed by nature to function in a hypoxic environment, promote vascularization, and differentiate into the critical endocrine cells that populate the pancreatic islets.
A number of radiotherapies that marry a small but potent amount of radioactive material and a targeted molecular compound have been gaining traction as progressive treatments for malignant NETs, which can develop wherever nerve cells and hormone - producing endocrine cells are present (e.g., gastrointestinal tract, pancreas, lungs, thyroid).
ViaCyte also has a proprietary protocol for generating more mature pancreatic endocrine cells in vitro.
Marciniak A, Selck C, Friedrich B, Speier S Mouse pancreas tissue slice culture facilitates long - term studies of exocrine and endocrine cell physiology in situ.
An image of tissue from a human colon uses fluorescent staining to show the presence of the protein alpha - synuclein (red) inside gut endocrine cells (green).
Alpha cells and beta cells are both endocrine cells meaning they synthesize and secret hormones — and they exist right next to one another in the pancreas in structures called islets.
According to findings published June 15 in the journal JCI Insight, Duke researchers and collaborators from the University of California, San Francisco, hypothesize that an agent in the gut might interfere with alpha - synuclein in gut endocrine cells, deforming the protein.
The researchers demonstrated this in a stunning time - lapse video (2015, Journal of Clinical Investigation) in which a gut endocrine cell is placed under the microscope near a neuron.
In just a few hours, the endocrine cell moves toward the neuron and fibers appear between them as they establish communication.
With the new finding of alpha - synuclein in endocrine cells, Liddle and colleagues now have a working explanation of how malformed proteins can spread from the inside of the intestines to the nervous system, using a non-nerve cell that acts like a nerve.
Liddle and other scientists were astonished at the video, he said, because the endocrine cells — which are not nerves — were behaving like them.
«Pre-clinical study suggests Parkinson's could start in gut endocrine cells: Protein linked to Parkinson's could spread from gut to nervous system.»
Accounting for about 1 percent of all pancreatic cancers, pNET is a cancer of the endocrine cells, known clinically as the islets of Langerhans, which exist in small clusters throughout the pancreas.
Many news outlets have reported that Jobs had insulinoma, meaning it was the insulin - producing endocrine cells that had turned cancerous.
Dr. Kulkarni's lab also focuses on the role of growth factor signalling in the renewal and differentiation of embryonic stem (ES) cells and induced pluripotent stem (iPS) cells with the aim of studying mechanisms that underlie differentiation into pancreatic endocrine cells.
When cultured upon selected combination of islet - specific laminins, pancreatic islets exhibited following effects: (1) robust spreading into flattened adherent clusters with heterocellular organization, (2) islets maintain functional ability for glucose - dependent insulin release, (3) all the endocrine cell types maintain specific markers expression and ability to proliferate.
JAIN, R., et al. «Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells.»
Chronic relapsing pancreatitis with progressive loss of both exocrine and endocrine cells and their replacement by fibrous connective tissue results in diabetes mellitus.