Sentences with word «endothelin»

Gender differences in the expression of endothelin receptors in human saphenous veins in vitro

Short - term hemodynamic effects of endothelin receptor blockade in dogs with chronic heart failure

To test whether these findings in mice and mouse cells have human relevance, the researchers used human skin samples to successfully demonstrate increased activation of TRPV4 and endothelin in human epidermis after UVB exposure.

In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin - 1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.

Knockout of endothelin type B receptor signaling attenuates bleomycin - induced skin sclerosis in mice.

Importantly, analysis of blood samples from 99 healthy individuals showed that the G allele at rs9349379 is associated with higher levels of Big endothelin - 1 (ET - 1), a precursor protein product of the EDN1 gene.

In an accompanying editorial, Kiran Chandrashekar, MD and Luis Juncos, MD (University of Mississippi) noted that there is a critical need to develop additional therapies to improve the treatment of diabetic nephropathy and that endothelin inhibitors hold considerable promise.

Stimulation of Transforming Growth Factor - ß1 - Induced Endothelial - To - Mesenchymal Transition and Tissue Fibrosis by Endothelin - 1 (ET - 1): A Novel Profibrotic Effect of ET - 1.

An indisputable effect of sex hormones on endothelin - 1 expression was reported in humans with androgens increasing and estrogens decreasing plasma levels, which was also verified in male to female and female to male transsexuals.

However, in diabetic cells endothelin - 1 expression is increased (285).

Endothelin -1-mediated vasoconstriction in mesenteric artery rings was higher in female diabetic mice, whereas no sex differences were seen in newly manifested animals (286).

, Thyme extract, but not thymol, inhibits endothelin - induced contractions of isolated rat trachea, 2008

Aerobic exercise training reduces plasma endothelin - 1 concentration in older women.

A recent study found that older individuals have up to 130 percent more endothelin - 1 in their blood than do younger people.8 That suggests that in the elderly, insulin may not be able to overcome elevated levels of the powerful vasoconstrictor ET - 1.

BACKGROUND AND PURPOSE Endothelin peptides are potent vasoconstrictors and thus are seen as potential cause of cerebral vasospasm after subarachnoid hemorrhage (SAH).

On the other hand, sex differences in endothelin receptor density and higher binding capacity in men were reported (283).

Further molecular analysis uncovered the entire sequence of events in this pathway, with each event affecting the next: UVB exposure activates TRPV4, which causes the influx of calcium ions, which brings in another molecule called endothelin, which triggers TRPV4 to send more calcium into the cells.

Higher levels of endothelin - 1 can cause the arteries to harden, suggesting a mechanism of action for rs9349379 to increase risk for certain vascular disorders.

«The biggest value of this work is the pinpointing of endothelin - 1 as a core gene for multiple vascular diseases.»

«The main value of our research is the pinpointing of the importance of endothelin - 1 and blood vessel constriction to multiple vascular diseases,» says senior author Sekar Kathiresan, a cardiologist at the Broad Institute of MIT and Harvard University.

Endothelin is known to cause pain in humans and also evokes itching, which could explain the urge sunburned patients feel to scratch their skin.

Atrasentan, which targets the endothelin receptor A and was initially developed to treat cancer, is known to reduce albuminuria.

Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin - 1

Mechanisms behind the consequences of castration resulting in endogenous androgen withdrawal were explained by effects on NO production, which is higher if testosterone is absent, and the endothelin B receptor, which may be directly influenced by testosterone and causes vasoconstriction.

Gender differences in vascular reactivity to endothelin - 1 (1 — 31) in mesenteric arteries from diabetic mice

Also, an increase in oxidative stress and endothelin - 1 can be observed.

Additional confirmation was given by another animal study showing more negative effects of androgens on glycemic control, BP, and endothelial and vascular response to endothelin - 1, thromboxane or NO (327).

A genetic variant associated with 5 vascular diseases is a distal regulator of Endothelin - 1 gene expression.

The presence of a guanine nucleotide at rs9349379 was associated with higher levels of the endothelin - 1 precursor protein produced by EDN1, as well as higher rates of coronary artery disease and lower rates of migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension.

But the team determined that the SNP, called rs9349379, actually regulates the expression of a different gene upstream: EDN1, which codes for a precursor of the endothelin - 1 protein.

New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.

Endothelin - l, a potent blood vessel constrictor linked to heart disease, is found by Kimmel Cancer Center investigators to play a role in advanced prostate cancer.

One of the factors now implicated in glaucoma - associated neurodegeneration is the endothelin (EDN) system, but the mechanisms are not yet known.

-- We have shown that the genetic change causing fibromelanosis is a complex rearrangement that leads to increased expression of Endothelin 3, a gene which is known for promoting the growth of pigment cells, explains Ben Dorshorst the post-doctoral researcher responsible for the work.

Darkfield images are displayed for the following genes: (A) hypothetical LOC553091, LOC553091, (B) neuro - oncological ventral antigen 2, Nova2, (C) protocadherin 9, Pcdh9, (D) endothelin receptor type B, Ednrb, (E) WAP four - disulfide core domain 2, Wfdc2, (F) SLIT - ROBO Rho GTPase activating protein 1, Srgap1, (G) BAC clone RP24 - 69C19 from Chromosome 6, (H) early B - cell factor 2, Ebf2, and (I) heat shock 70kDa protein 12A, Hspa12a.

It would have been good if someone had done an advanced lipoprotein analysis on you and had measured some specific inflammatory markers like IL - 6, IL - 17, TNF - a, and endothelin.

Nitric oxide enhances blood flow, and endothelin - 1 restricts it, either by directly constricting blood vessels or by suppressing NO production.

It combines some of the actions of ARBs with those that reduce the effects of endothelins, compounds that increase blood pressure.

Her research interests during her residency included novel therapies for the treatment of canine pulmonary hypertension (endothelin) antagonists as well as echocardiographic evaluation of the heart's «pump» function in the setting of mitral valve disease.