Sentences with phrase «epigenetic reprogramming»
"Epigenetic reprogramming" refers to the process of modifying the gene activity without altering the DNA sequence. It involves resetting or changing the instructions that determine how our genes are expressed, which can impact our health and development. It's like rebooting a computer or resetting the settings, but instead, it happens within our cells and can have long-lasting effects on our traits and characteristics. Full definition
As explained by lead researcher, Dr Ferdinand von Meyenn, postdoctoral researcher in the Epigenetics research programme at the Babraham Institute and first author on the paper: «Our method establishes a reliable system that can be used to explore the early stages of epigenetic reprogramming in primordial germ cell - like cells and how this is regulated in the generation of reproductive cells.
sciencedaily.com
Reporting research in the scientific journal Cell, Vienna - based scientists from the Institute of Molecular Biotechnology (IMBA) have discovered that not only do fertilized egg cells trigger epigenetic reprogramming of sperm DNA but this process is closely monitored to safeguard genomic integrity.
«Using fertilized mouse eggs, we showed that the egg cell actively triggers demethylation of the paternal DNA — in other words, it initiates epigenetic reprogramming by stripping any previous epigenetic memory passed on from the father.
The ultimate goal is to precisely understand the mechanisms of checkpoint blockade effectiveness and bring next generation, sustainable immunotherapies to even more patients, perhaps using by using epigenetic drugs in combination with checkpoint blockade to allow epigenetic reprogramming of exhausted T cells into durable and functional memory T cells.
ANT - OAR makes use of a process known as epigenetic reprogramming to convert an adult cell into an embryonic stem cell.
«It is possible that also in humans, inflammatory diseases that primarily develop outside the brain could trigger epigenetic reprogramming inside the brain,» says Neher.
«Instead, the benefit we see after PD - 1 pathway blockade is caused by only transient changes in gene expression that is not durable, rather than permanent epigenetic reprogramming.»
She studies epigenetic reprogramming in stem cells.
Since the in vitro reprogramming systems are characterised by very low efficiency Petra's lab focuses on the systems where epigenetic reprogramming occurs naturally as a part of normal embryonic development.
His research focuses on understanding the molecular mechanisms driving epigenetic reprogramming in cancer and on translational aspects of cancer epigenetic therapy.
This is only achievable via epigenetic reprogramming and replicative senescence hayflick limi tsolving.
Environment - induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.
«In short,» said Pandey, «epigenetic reprogramming in the brain due to early life experiences or exposure to alcohol can lead to the changes in gene functions and predispose an individual to adult psychopathology.»
It also should relieve the worries of the scholars involved with the journal Communio ¯ the use of oocytes in epigenetic reprogramming was one of the major reasons they feared the resulting cell was a disabled embryo.
New research shows that adolescent binge drinking can lead to epigenetic reprogramming that predisposes an individual to later psychiatric disorders such as anxiety.
The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.
The researchers identified a surveillance mechanism that not only monitors DNA lesions caused by epigenetic reprogramming but also fixes the damage.
As sperm mature over several weeks, this epigenetic reprogramming results in a compact nucleus that is essential for fertilization.
For example, epigenetic reprogramming, a process of erasing and remodeling epigenetic marks, is essential for sperm maturation and represents a critical window of susceptibility to environmentally - induced epigenetic errors that, in turn, may influence reproductive health.»
«The epigenetic reprogramming from stress, through glucocorticoids, was surprising,» says other senior co-author Xuejin Chen, also at the Shanghai Jiao Tong University School of Medicine.
Understanding this specialized chromatin «ground state» has the potential to provide insights into the yet mysterious process of epigenetic reprogramming to totipotency, the ability to give rise to all cell types.
«Genetic, epigenetic reprogramming, and subsequent gene - diet interaction are all possible explanations,» he said.
Unistem, the centre for stem cell research, directed by Prof. Elena Cattaneo — NeuroStemcell PI, has invited Prof. Azim Surani from the Gurdon Institute in Cambridge to give a lecture on «Germ line, stem cells and epigenetic reprogramming».
It includes 69 definitive chapters on topics ranging from «molecular bases of pluripotency» and «nuclear cloning and epigenetic reprogramming» to «ethics of human stem cell research.»