Sentences with word «exocytosis»

... [For example], A deficiency of lysosomal sialidase (Neu1) leads to increased levels of LAMP -1-mediated lysosomal exocytosis by neutrophils in the bone marrow cavity.

Increased LAMP1 levels were followed by excessive lysosomal exocytosis in nerve cells, resulting in increased release of Alzheimer - linked peptides from neurons.

Sandra Schubert (Solimena, TUD)-- «The Role of Beta2 - Syntrophin Phosphorylation in Secretory Granule Exocytosis» (2006)

About Blog Hepatitis C viraemia is carbohydrate - dependent because the virus piggy - backs on triglyceride assembly and VLDL exocytosis.

Although SNARE complexes containing open syntaxin - 1 and Munc18 - 1 are essential for exocytosis, the function of closed syntaxin - 1 is unknown.

This regulation is spectacularly apparent in the exquisite speed and precision of synaptic exocytosis, where synaptotagmin (the calcium - ion sensor for fusion) cooperates with complexin (the clamp activator) to control the precisely timed release of neurotransmitters that initiates synaptic transmission and underlies brain function.

Tsuboi, Takashi, et al. «Age - dependent preferential dense - core vesicle exocytosis in neuroendocrine cells revealed by newly developed monomeric fluorescent timer protein.»

The synaptic vesicle protein that mediates membrane fusion during exocytosis also regulates the rate and extent of this process by controlling vesicle tethering.

While working on his Ph.D., Dr. Taraska investigated the processes of triggered exocytosis and endocytosis in neuroendocrine cells with high - resolution microscopy methods.

The process by which new membrane proteins are sent to the membrane is called exocytosis.

Structural organization of the synaptic exocytosis core complex.

In Neu1 - deficient mice the excessive lysosomal exocytosis results in cleavage of VCAM - 1, loss of bone marrow progenitor cells from the bone niche and the onset of spleenic hematopoiesis.

This unique combination of the genes demonstrates that there is a connection between exocytosis and the remodeling of the cell's internal skeleton, but what that connection is remains unclear.

The research team identified the novel gene, known as For1F, while studying exocytosis.

This led to decreased exocytosis of ATP from astrocytes, resulting in decreased purinergic signaling on dopaminergic neurons.

The Exocyst complex, which functions in polarized exocytosis, has been involved in regulation of cell motility.

The mechanism of loss probably involves exocytosis and possibly blood transport.

To truly conclude that Remofuscin is inducing exocytosis of lipofuscin the authors could have tested the drug in RPE cells pre-loaded with A2E.

We further demonstrate that lysosomal exocytosis mediates the resealing of primary skin fibroblasts wounded during the contraction of collagen matrices.

We have the RPE cell model up and running, we know how to monitor A2E clearance in these cells by immunoflourescence and by HPLC and we also know how to monitor lysosomal exocytosis biochemically.

[MR: This is because lack of Neu1 means that it's not available to strip sialic acids from LAMP - 1, and oversialylated LAMP - 1 leads to loss of its inhibitory function over lyso exocytosis, apparently leading to a nonspecific puking out of its contents into the ECF].

As L - channels play a crucial role in the control of catecholamine release in chromaffin cells, the two opposite modulations mediated by Gi / o proteins and cAMP may represent an effective way to broaden the dynamic range of Ca2 + signals controlling exocytosis.

Rothman immediately realised the importance of the result, and proposed the «SNARE hypothesis» for vesicle transport and exocytosis as a general process in all cell types: vesicle proteins specifically bind to target proteins in the plasma membrane to form a «v - t» complex which is necessary for vesicle and membrane fusion to proceed.

«This arrangement would ensure that exocytosis occurs both at restricted sites and with an extremely rapid time course,» wrote Scheller (Science, vol 257, 10 July 1992, p258).

About Blog Hepatitis C viraemia is carbohydrate - dependent because the virus piggy - backs on triglyceride assembly and VLDL exocytosis.

Using physiological assays, Scheller demonstrated the importance of these proteins for exocytosis.

I: Exocytosis of milk protein, lactose, and other components of the aqueous phase in Golgi - derived secretory vesicles.

Exosomes are small endosome derived lipid nanoparticles actively secreted by exocytosis in most living cells

Thus, FMLP appears to generate some important excitatory signal in addition to a rise in [Ca2 +] i and exocytosis and superoxide generation in neutrophils may not be simply dependent on [Ca2 +] i as is widely supposed.