Sentences with phrase «exposure to the drug»

Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse.

Genetic or environmental influences, rather than prenatal exposure to the drugs, may have a greater influence on whether a child will develop these disorders.

Thus far, such side effects seen in clinical trials have been minor, but it sometimes takes years of exposure to a drug before deadly infections show up, he says.

It might also evolve resistance by exposure to the drug.

The expression levels of more than 12,000 genes in these cells were then measured in both groups, both before and after exposure to the drug.

But by 12 days, the physiological changes required to extend lifespan were complete and lifelong exposure to the drug had no additional effect.

However, some research has found an association between greater exposure to the drugs before age 3 and problems with learning and behavior, including an increased risk of attention deficit hyperactivity disorder.

Drug effects depend heavily on the dose, route of administration, previous exposure to the drug, and the expectation of the user.

Mothers found positive for THC in urine screens should be strongly advised to avoid continued exposure to this drug while breastfeeding and should be counseled that continued exposure of their infants to cannabis may produce severe long - term neurobehavioral consequences.

The «pregnancy» section outlines the likelihood and seriousness of developmental abnormalities from exposure to a drug; when it should be prescribed; side effects; clinical trial data; directions for use during labor and delivery; and alternative treatments, if applicable.

Dr. Chartoff is interested in how chronic exposure to drugs of abuse changes the brain at molecular and cellular levels such that drug withdrawal elicits a protracted constellation of negative affective signs.

Epigenetic translates to «above genetic» and is an emerging field of study that looks at how environmental factors — such as infections, pollutants, stress and, in this case, long - term exposure to drugs that block estrogen synthesis — could influence a person's DNA.

In the absence of the enzyme, indomethacin reabsorption into the circulation was reduced, resulting in increased elimination, a shortened half - life, and reduced exposure to the drug.

The warnings will apply to children under 3 and to pregnant women during their third trimester, and pertain to procedures that last longer than three hours or to repeated exposure to the drugs.

To begin to explore possible molecular mechanisms by which longer exposure to a drug might result in a more rapid recovery following cessation of treatment, we made note of a study reporting changes in the levels of expression of efflux and influx membrane transporters in testes after oral administration of adjudin (27).

When she came to Novartis, she was happily surprised that «Novartis was actually really research oriented [and] somewhat similar to an academic research environment» with a strong focus on publishing, but still made it so she could «get exposure to the drug discovery process.»

Many scientists believe that chronic low level exposure to these drugs and other toxins, could be subtly bringing on allergies, causing nerve damage, hampering fertility and development, damaging the brain and changing behavior, causing cancer and a multitude of other problems and diseases.

Micotil 300, a prescription injectable antibiotic used to treat respiratory disease in cattle and sheep, has been voluntarily withdrawn amid a government alert about human exposure to the drug.

Indiscriminant use of antibiotics accelerates these mutations by allowing bacteria to survive exposure to the drugs.

Indian vultures have suffered population declines of 97 - 99 %, with the annual rate of decline of 16 % in the first part of this century, all because of exposure to the drug diclofenac, given to farm animals to reduce joint pain and allow them to work longer.

So — and, obviously, there are some other risks that you really hope children aren't exposed to but that — and that includes exposure to drugs — particularly illicit drugs and alcohol in utero, which also — I think there's some increasing evidence that that can, again, make children more irritable or impact on their neurological and cognitive development later on.

He said that breaking Aboriginal connection to land and culture, and forcing people to move to regional towns will just increase exposure to drugs, alcohol, and crime, with no guarantees of adequate housing or employment.

Early exposure to drugs and alcohol, genetic conditions, or neurological issues might all impact a child's ability to successfully attach to caretakers.

The primary outcome measures will be the difference in BOLD fMRI activation between drug - exposed participants and those without prenatal exposure to drugs of abuse.

Hannah and Sarah both have juvenile rheumatoid arthritis and all the children have lasting illnesses due to exposure to drugs while in the womb.

Since amiodarone HCL is known to exert its cytotoxic effect through the extrinsic, caspase - 9 independent apoptotic pathway [33] our microarray results confirm that the differential cytotoxic effect seen in NSCs treated with amiodarone HCL is due to specific activation of extrinsic apoptosis pathways resulting from exposure to the drug.

«Chronic exposure to drugs of abuse causes changes in the brain that could underlie the transition from casual drug use to addiction.

«If people have an addiction and their brain has been changed by exposure to drugs, the basic workings of the brain become different.

Prenatal exposure to drugs of abuse — May 2011.

This is compared with the therapeutic dose of the drug, and the «rate of clearance» of the drug by the baby is also taken into account — the lower the level of clearance, the higher the baby's exposure to the drug.

In addition, secondhand smoke increases the baby's exposure to the drug.

Microdosing also reduced the eye's exposure to the drug and preservative by 75 to 80 percent.

In this new, unbiased, «trend - in - trend» design, researchers monitor changes in frequency of outcomes as they relate to changes in an exposure to a drug across groups that adopt the drug at different rates.

Because the drug remains tethered to the DNA parcel, a body's exposure to the drug can be controlled by closing and opening the gate.

By limiting the world's exposure to the drug, doctors can stave off resistance even longer — and save Teixobactin as a much - needed last resort for gram - positive infections.

But recent studies in humans have suggested that prenatal exposure to these drugs could lower IQ scores and cause wide - ranging cognitive deficits in childhood.

Talk to your canine the layer is glossy have, and also do delight in and determine if their exposure to drug.

The article covers how a judge in the U.S. District Court in Connecticut excluded the plaintiff's medical causation expert on Daubert grounds after finding insufficient evidence of the plaintiff's exposure to the drug, which was necessary to support the expert's opinion on specific causation.

Adolescents seek independence but can find themselves alone and struggling with peer relationships, pressures to succeed, and exposure to drugs and alcohol.

Many of these caregivers may be seniors, in poor health, socially isolated and / or emotionally and financially unprepared to assume the responsibilities of children who may have emotional and behavioral issues resulting from separation, grief, loss, multiple placements, prenatal exposure to drugs, and / or abuse or neglect.

However, it is also the case that those at risk for becoming drug abusers in adolescence show some of these same brain characteristics before exposure to drugs and alcohol.