Sentences with phrase «failed clinical trials»

Currently, 92 per cent of new drugs fail clinical trials, even though they have successfully passed animal tests.

Pharmaceutical companies have sunk billions of dollars into drugs aimed at preventing or reducing the disease's hallmark plaques, abnormal brain deposits of a protein fragment called β amyloid, but a long list of failed clinical trials has led many to question that strategy.

During a conversation this month in his office at Weill Cornell Medicine in New York City, Fine rattled off more dismal stats, like the many failed clinical trials of experimental drugs for glioblastoma; like the paltry increase in life expectancy for people with glioblastoma from 12 months in 1990 to 15 today; like the stupid (in hindsight) assumptions about how glioblastomas grow and how to study them in mice.

Developing new drugs, however, is a very lengthy and expensive process and many promising drugs fail clinical trials because of unanticipated toxicity and side effects.

Still, no GVHD treatment has yet received regulatory approval, and with a limited market and a long history of failed clinical trials, drugmakers are leery of getting involved.

The value of Innate's shares tanked in late - June following a failed clinical trial for its multiple sclerosis treatment.

After a failed clinical trial earlier this summer, the company's stock plummeted.

Shares plummeted Tuesday by more than 90 percent on a failed clinical trial for its multiple sclerosis treatment.

Ironically, notes Okochi, considering his findings, he argues the failed clinical trials affirm the Aβ hypothesis.

The two failed clinical trials were based on the theory that too much of the protein mGluR5 leads to an excessive response to the excitatory neurotransmitter, which in turn leads to hyperexcitable neurons.

It's easy to forge ahead with incomplete information, but the risk of doing so is greater likelihood of another failed clinical trial.

In an early Phase I study, an Alzheimer's drug candidate showed reduced side effects compared with similar drugs that have failed clinical trials.