1989 - Dr. Mattie Hendrick, V» 78, provides the first link between vaccination and the development of
fibrosarcomas in cats.
There are cases of an aggressive form
of fibrosarcoma developing in dogs under 1 year of age.
At Litchfield Veterinary Hospital we use Purevax and Continuum vaccines, which contain no adjuvant and have not been associated
with fibrosarcoma.
In rare cases a tumor
called fibrosarcoma may develop at the injection site, however, this has been found to develop in only specific individuals who are genetically predisposed to form these tumors secondary to any type of infection or inflammation.
Treatment of
Feline Fibrosarcoma with Lipopolysaccharide and Cyclophosphamide A Case Report E.J.Miller, W.A. Hadden, G Soma (Version 1.0)
I mentioned in my article on vaccination - associated feline
fibrosarcoma tumors that they were difficult for veterinarians to cure.
Dogs with
oral fibrosarcomas in the mouth may have increased drooling, bloody oral discharge, difficulty swallowing and eating.
HT - 1080
fibrosarcoma cells were supplied by ATCC and maintained in culture as described by the provider.
Two patients with advanced
infantile fibrosarcoma experienced sufficient tumor shrinkage with larotrectinib to allow for limb - sparing surgery with curative intent; both patients had negative margins after surgery, and they both remained progression - free without larotrectinib treatment after 4.8 and 6.0 months of follow - up.
When a cat is developing a vaccination -
related fibrosarcoma, owners notice a small lump when they are petting or grooming their cat.
However, there is almost never a valid reason to vaccinate older, house - confined cats (or dogs)(ref1, ref2) You can read more
about fibrosarcomas in cats here.
These lumps are usually normal and do not
represent fibrosarcomas (which generally take years to develop, not weeks).
Fibrosarcoma incidence is extremely rare with different studies reporting an incidence between one in 1000 to one in 10,000 vaccines administered.
Fibrosarcoma mostly affects older male dogs, starting at their skull, spine, pelvis and ribs before growing towards the skin like tentacles.
Horus Cat California Diagnosis: Undifferentiated Sarcoma (
likely Fibrosarcoma) Treatment: Radiation and oncology care
Cats are most commonly diagnosed with squamous cell carcinomas followed
by fibrosarcomas.
It has been about 1.5 years since Kismet had a
large fibrosarcoma removed from inside her head (resulting also in the removal of her left ear), and about 14 months since she completed 4 weeks of radiation treatment.
Eating a foreign object that must be surgically removed, boy - cat urinary problems requiring surgery (urethrostomy), kidney cancer, bladder stones, other cancer, radioactive treatment for over-active thyroid,
malignant fibrosarcoma skin tumors, Kidney cancer, intestinal cancer
The prognosis of
fibrosarcomas depends on the location (for ease of excision and margin of healthy tissue available for removal) and grade (determined by cell divisions (mitotic index) or the speed at which the tumor is growing).
SECTION 2: SELECTED TOPICS ON CLINICAL PATHOLOGY Adenocarcinoma Behavioral Problems Canine Hip Dysplasia Ear Infections (Otitis)
Epilepsy Fibrosarcoma Gastric Dilation - Volvulus (GDV) or Bloat Hemangiosarcoma Hypothyrodism Lymphoma Malignant Histiocytosis Mast Cell Tumors Melanoma Nonmalignant Tumors of the Skin and Soft Tissues Osteochondrosis Osteosarcoma Patellar Luxation
We utilize an inactivated, non-adjuvanted rabies vaccine for cats because this vaccine is less likely to stimulate an inflammatory response at the site of the injection that could, in rare cases, trigger the development of a potentially life -
threatening fibrosarcoma tumor.
Multiple myelomas (immune system tumors), thymomas (thymus gland tumors), osteosarcomas (bone tumors), and
fibrosarcomas also have the potential to raise the blood calcium level of pets.
Oral
fibrosarcomas most commonly occur on the maxilla (the upper jaw), but have been known to grow on the mandible (the lower jaw) of companion animals.
Adjuvants have become controversial in cats especially and may be associated with tumor (
especially fibrosarcoma) formation.
Pathologists, examining these tumors, found that most were highly malignant tumors of the connective tissue of the body
called fibrosarcomas.
Even microchips, devices with 1 / 10th the volume of a 0.5 ml vaccination, occasionally
induce fibrosarcomas in cats.
A cat positive for the feline leukemia virus is particularly at risk for developing multiple tumor types
including fibrosarcoma.
Adjuvanted Feline leukemia vaccine can cause Injection
Site Fibrosarcomas, a fatal type of cancer.
It includes autoimmune diseases of the thyroid, joints, blood, eyes, skin, kidney, liver, bowel and central nervous system; anaphylactic shock; aggression; seizures; epilepsy; and
fibrosarcomas at injection sites, especially in cats.
The most common tumor type was salivary gland tumor (22 %), followed by other soft tissue sarcomas (20 %),
infantile fibrosarcoma (13 %), thyroid tumors (9 %), and other malignancies occurring in 4 or fewer patients.