Sentences with phrase «to form tumors»
Can any cancer cell form another tumor, or is it only select cancer stem cells that give rise to new cancer cells?
uofmhealth.org
They also do not form tumors when monitored over many generations.
The cells formed tumors that grew to a diameter of one - fifth of an inch or more.
Plasma cell neoplasms are diseases in which abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body.
«Unlike most cancers that require multiple hits, we found that this particular mutation can form a tumor all by itself,» says Peter W. Lewis, an assistant professor of biomolecular chemistry in the School of Medicine and Public Health at the University of Wisconsin — Madison.
The animals formed tumors within a few weeks.
Importantly, mutant mice lacking these amino acids have abnormal chromosome numbers and form tumors at high frequency.
Soll's team, in a paper published in PLOS One in March 2015, previously showed that human breast cancer cells form tumors by extending cables — bridges of sorts — between small aggregates of cancer cells.
Embryonic stem cells derived from human blastocysts have the key advantage of pluripotency, meaning that they form nearly all cell types but also have the disadvantage of forming tumors in vivo, which may limit clinical application to tissue engineering rather than cell transplantation.
This disease occurs when the myeloma cells form tumors outside of the bone marrow in the soft tissues or organs of the body.
«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.
Most breast cancer deaths occur because the cancer has spread, or metastasized, which means that cells in the primary tumor have invaded blood vessels and traveled via the bloodstream to form tumors elsewhere in the body.
The image shows red endothelial progenitor cells expanding and proliferating forming tumors between the green muscle fibers.
When transplanted into immunosuppressed mice, these low - fluorescence stem cells rapidly formed tumors, whereas high - fluorescence stem cells did not.
«Another model is punctuated evolution in which CNAs are acquired in short bursts of crisis, followed by stable clonal expansion that form the tumor mass.
Furthermore, when the team suppressed STAP - 2, the prostate cancer cells showed reduced proliferation and did not form a tumor when transplanted into mice.
The replicating lab obtained samples of the human skin cells used in the original study, which had been engineered to slowly form tumors, and implanted them in mice.
Cancer - causing mutations break this switch: a genetic defect in the K - Ras protein prevents it from converting GTP to GDP, forcing K - Ras to continue trumpeting its message through the cell like a zombie Paul Revere, driving the cell to the excessive growth and repeated divisions that eventually form a tumor.
We invented a method that identified that S1P levels are high not only in breast cancer cells, but also in interstitial fluid that forms tumor microenvironment (Nagahashi M et al, Journal of Mammary Gland Biology and Neoplasia 2016).
Mouse iPSCs demonstrate important characteristics of pluripotent stem cells, including expressing stem cell markers, forming tumors containing cells from all three germ layers, and being able to contribute to many different tissues when injected into mouse embryos at a very early stage in development.
Mast cells can be found in all tissues of the body but typically form tumors on the skin in close to 20 percent in the canine population.
About 50 % of these male dogs form tumors in their testicles.
In rare cases a tumor called fibrosarcoma may develop at the injection site, however, this has been found to develop in only specific individuals who are genetically predisposed to form these tumors secondary to any type of infection or inflammation.
Abnormal cells are created, forming tumors which invade surrounding healthy tissue.
Metastatic cancer cells have the ability to break free from tissue, circulate in the blood stream, and form tumors all over the body, in a way acting like blood cells.
In the replicators» hands, however, cancer cells with and without the PREX2 mutations both formed tumors within a week — not weeks as originally reported — making it impossible to tell whether PREX2 made any difference.
Injected into rodents, the cells don't form tumors; rather, they migrate through the animals» brains, where they differentiate into various types of neural cells including the cells that create the myelin that protects nerve fibers.
In multiple myeloma, abnormal plasma cells (myeloma cells) build up in the bone marrow and form tumors in many bones of the body.
Researchers at the University of Iowa did just that, documenting in real time and in 3 - D how melanoma cells form tumors.
These antioxidants are partly responsible for halting DNA damage, which means cancerous cells can not mutate and form tumors.
Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a tumor.
With that knowledge, they screened more than four dozen monoclonal antibodies — unique agents that can stop cells from growing or forming tumors and can be mass produced — before finding two that block tumor creation in both types of cancer.
«What our findings show is that the problems with iPS cells don't just involve one or two or a few abnormal iPS cells escaping into the body and forming tumors, but that the whole population of cells is screwed up,» Lanza says.
The cells waste no time finding their cancerous cousins, slashing their way through a lab - prepared gel to quickly join other melanoma cells and form tumors.
The stem cell procedure on his spine could rob him of what little mobility he had left, and the foreign tissue could clump together, forming a tumor.
Breast cancer cells, in contrast, are more ponderous and lumbering in both their movements and in forming tumors.
One problem with using iPS cells therapeutically is that the reprogramming process creates cells prone to forming tumors.
Biology professor David Soll and his team used unique computer - assisted 3 - D reconstruction software to chronicle how both breast tissue cancer cells and melanoma cells form tumors.
Melanoma cells move quickly, extending cables to reel in other cells and form tumors.
The genome - wide epigenetic changes clustered in certain chromatin domains and controlled «gene expression changes that specify different malignant traits, including the ability to form tumors,» McDonald said.
This tougher ECM is vital for the cancer cells to migrate throughout the body, signal to one another, and form tumors.
The key is in making these macrophages more prone to «steal» sugar from the cells forming the tumor's blood vessels.
When cancer cells start dividing rapidly to form tumors, these cells are actually reverting to an earlier time in their development when they were supposed to divide rapidly.
When they disrupted either POSTN or the integrin receptor, they found a dramatic loss of CSCs and an impaired ability of the cancer cells to form tumors.
As with results of their earlier studies, the investigators found that the higher the expression of this protein, the more aggressive the cancer, which is determined by how the cells invade other tissue types and their ability to form tumors in laboratory models of cancers.
This meant they were able to remove very immature (undifferentiated) cells that could form tumors.
Topping the list was p53, a protein often called the «guardian of the genome» because it causes damaged, out of control cells to commit suicide, or apoptosis, which reduces the likelihood that they will go on to form tumors.
Even a syringe of one's own stem cells taken from one part of the body and squirted into another «may multiply, form tumors, or may leave the site you put them in and migrate somewhere else» the fda warns on its Web site.
Researchers might also be able to target microRNAs directly, altering their levels to make cancer cells less likely to form tumors.