Sentences with phrase «free survival»

Many other studies have shown a positive correlation between physical activity and disease - free survival in breast cancer.

In other words, chance of overall and progression free survival doubled.

The median progression - free survival time for recurrent ovarian cancer is 3 months, and median overall survival is less than 12 months.

Trial results showed a near doubling of progression - free survival benefit for the combination therapy over use of the single drug alone.

With best treatment, 10 - year disease - free survival varies from 98 % to 10 %.

No significant difference in median progression - free survival occurred between the two treatment arms.

A secondary objective of this study is to assess the efficacy and determine progression - free survival in treated cats.

The expression level of CXCR4 can be used as an independent prognostic factor for disease free survival of SCLC patients [37].

The interim analysis found a median progression - free survival rate of 9.7 months with consolidative radiation therapy followed by chemotherapy, versus 3.5 months for maintenance chemotherapy alone (p = 0.01; Hazard Ratio (HR) = 0.304, 95 % CI 0.113 - 0.815).

Median progression - free survival with niraparib compared to placebo was 21.0 vs 5.5 months in the germline BRCA mutation group (hazard ratio [HR] 0.27, 95 % confidence interval [CI] 0.173 to 0.410, p < 0.0001), 9.3 months vs 3.9 months in the non-germline BRCA mutation group (HR 0.45, 95 % CI 0.338 to 0.607, p < 0.0001), and 12.9 vs 3.8 months in a subgroup of the non-mutation cohort who had homologous recombination DNA repair deficiencies (HRD)(HR 0.38, 95 % CI 0.243 to 0.586, p < 0.0001).

The 10 - year disease free survival rates were 47.0 % (CI 42.2 - 51.6 %) for the patients receiving adjuvant chemotherapy and 43.7 % (CI 39.1 - 48.2 %) for those in the surveillance groups (HR = 0.91, 95 % CI 0.77 - 1.08, p = 0.29).

Results from this new study showed that nivolumab did not result in longer progression - free survival compared with chemotherapy in the overall population.

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Autologous stem cell transplantation was one of the first forms of immune regenerative treatments to show that patients can have long term disease free survival after the transplant by re-instatement of immune surveillance.

The addition of necitumumab to gemcitabine and cisplatin chemotherapy improved overall survival and progression free survival by 21 % and 16 %, respectively, as compared to chemotherapy alone in patients whose tumours expressed the EGFR protein.

Progression - free survival for patients in both the low - and high - dose groups was identical, about 8.6 months.

The estimated progression - free survival at two years was 33.1 % (95 % CI: 19.1 % — 47.9 %) in patients aged under 65 years and 44.4 % (95 % CI: 25.6 % — 61.8 %) in the elderly subgroup (P = 0.74).

Median progression - free survival among patients receiving selumetinib was more than double that of patients receiving chemotherapy (15.9 weeks vs. 7 weeks).

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(E) Kaplan — Meier tumor - free survival curves comparing MMTV - tva and WAP - tva virgin mice injected with RCAS - caErbb2.

We further found that in about 15 % of patients with FLT3 - ITD mutations, loss of the wt - FLT3 allele can be observed, and these patients have a particularly poor outcome, with a median disease free survival between 4 and 6 months.

Amgen Executive Vice President of Research and Development Sean Harper said the study was designed to explore Kyprolis dosing regimens, noting that the the trial did not meet its goal in improving progression - free survival versus Velcade in patients who had not yet been treated for the disease.

Despite these significant recurrence - free survival results, the trial also found important side - effects, in particular the following grade 3 — 4 immune - related adverse events were reported: gastrointestinal, 75 events (16 %) in the Ipilimumab group and four (< 1 %) in the placebo group, hepatic, 50 (11 %) in the Ipilimumab group and one (< 1 %) in the placebo, and endocrine, 40 (8 %) in the Ipilimumab group and none in the placebo group.

The combination of the BRAF inhibitor encorafenib with the MEK inhibitor binimetinib yielded improved progression - free survival over vemurafenib in a phase III trial of patients with advanced BRAF V600 — mutant melanoma.

The best outcome for HSCT is to perform it after the first CR as it had been noted in studies to have a significantly lower overall survival and progression - free survival when done after the first CR [5, 11].

Although it took slightly longer for the cancer to progress in patients receiving bevacizumab (10.7 months vs. 7.3 months), the rate of progression - free survival did not meet pre-specified criteria to be statistically meaningful, according to Dr. Mehta.

HIV - free survival means the absence of a combined outcome of either (1) HIV infection or (2) death before HIV infection due to other causes.

«Adding radiation to chemotherapy may dramatically improve survival for advanced NSCLC: Randomized phase II trial finds progression - free survival expectancy nearly tripled with addition of consolidative stereotactic radiation therapy for limited metastatic disease.»

Median progression - free survival improved by 4.5 months, from about six months in the control group to about 10.5 months among those treated.

When they looked at publically available data on patients, they were able to predict the likelihood of progression - free survival based on whether the cancer cells had high levels of IL13RA2.

«Further analysis of this cohort revealed that disease - free survival increased by 46 % among the subgroup of nut consumers who ate tree nuts rather than peanuts,» said Charles S. Fuchs, M.D., M.P.H., director of Yale Cancer Center and senior author of the study.

A team led by scientists at Duke Clinical Research Institute finds that in North Carolina from 2010 to 2013, brain damage — free survival rose from 7.1 to 9.7 percent in cardiac arrest patients — mainly due to bystanders doing chest compression before medical personnel arrived.

Researchers assigned each type of physical activity an intensity score and determined walking or bicycling just 20 minutes per day was associated with a 21 percent lower risk of heart failure and accounted for the largest difference in heart failure free survival.

The monitoring of tumor formation of these stable cells in vivo resulted in no statistically significant difference in tumor - free survival driven by PREX2 variants, whereas the original study reported that these PREX2 mutations increased the rate of tumor incidence compared to controls (Figure 3B and S6B; Berger et al., 2012).

Dr Larkin said: «Results from our large analysis of pre-defined sub-groups of patients with advanced melanoma provide evidence that suggests the combination of the two drugs consistently improves progression - free survival across a range of sub-groups, including patients with poor prognostic factors, when compared with either nivolumab or ipilimumab alone.»

Interestingly, analysis of lymphocytes from breast cancer patients showed that signatures of NK cell activation predicted relapse - free survival post initial surgery.

The independent factors used to predict progression free survival include levels of beta2 - microglobulin, longest diameter of the largest lymph node involved, bone marrow involvement, and hemoglobin levels.

Despite previously reported progression - free survival improvements with cediranib, results from the ICON6 trial failed to show a statistically significant improvement in overall survival.

Our progression - free survival difference was very impressive and better than we anticipated.»

Using their experience from HD trials, the researchers assumed that a trial using these new progression - free survival endpoints would last for 3 years, and that about 1 in 10 of the participants will drop out.

Fourteen - year disease - free survival falls to 69 percent for patients who have a high microvessel count combined with low nm23, but still have high or moderate E-cadherin levels.

Age and cytogenetics as predictors of event free survival in patients with acute non-lymphocytic leukemia receiving high dose cytosine arabinoside and daunorubicin as consolidation chemotherapy.

Independent cohorts of breast cancer patients with overall survival or metastasis - free survival data available were examined.

Tumor - free survival analysis was done using the Generalized Gehan - Wilcoxon test with rho = 1, and Kaplan - Meier survival curves were generated in R.

But I also know that the early two - and four - year studies on the growing number of people who have had progression - free survival suggest that our responses have been generally durable.

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