Sentences with word «gametocyte»

In blue are Plasmodium falciparum malaria parasites in the sexual, gametocyte stage of development.

Study protocol for a randomised controlled double - blinded trial of the dose - dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda

Her newest project, funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, will look at the crucial time when malaria is transmitted — when reproductive cell precursors known as gametocytes develop.

About 3 years ago, I performed an experiment that worked out well: Somehow, with careful cultivation, I turned a couple of gametocytes into this thing that knows how to negotiate for ice cream.

Two teams have independently discovered that a single regulatory protein acts as the master genetic switch that triggers the development of male and female sexual forms (termed gametocytes) of the malaria parasite, solving a long - standing mystery in parasite biology with important implications for human health.

For mosquito transmission to occur, the sexual form gametocytes, which are structurally distinct and have a very different program of gene and protein expression, have to form continually in the blood on a 2 - day cycle.

In what was originally a separate line of investigation, David Baker and Taane Clark and colleagues at the London School of Hygiene & Tropical Medicine and the Wellcome Trust Sanger Institute analyzed the whole - genome sequences of two P. falciparum laboratory strains that they knew were unable to produce gametocytes.

Compared to the new assays, the current molecular standard assay failed to identify 16 % of infections, and at least 40 % of those contained parasite gametocytes, the parasite stage that is transmitted when mosquitoes bite an infected person.

The protein, AP2 - G, is necessary for activating a set of genes that initiate the development of gametocytes — the only forms that are infectious to mosquitos.

The study led by Llinás was initiated by experiments from Alfred Cortés» group at the Barcelona Centre for International Health Research, in which individual human malaria parasite clones from a single strain were found to have varying levels of the transcriptional regulator AP2 - G, which mirrored varying levels of sexual stage (gametocyte) production.

Every other cell type in the mammalian body, apart from the sperm and ova, the cells from which they are made (gametocytes) and undifferentiated stem cells, is a somatic cell; internal organs skin, bones, blood and connective tissue are all made up of somatic cells.

The gametocytes can stay in a person's body for several weeks following treatment for malaria.

The parasites split in the patient's red blood cells, forming male and female sex cells (gametocytes).

«Finding new drugs that will also target the gametocyte stages of the malaria parasite are essential to reduce its transmission,» Cassera said.

Studies conducted by Cassera and Paul Roepe, professor of chemistry and professor of biochemistry and cellular and molecular biology at Georgetown University, showed that one of the three compounds kills the malaria parasite in its asexual stage as well as its gametocyte stage, which is when transmission to mosquitoes occurs.