Sentences with phrase «genome integrity»
The phrase "genome integrity" refers to the overall health and stability of an organism's genetic material, specifically its DNA. It means that the genetic information within an individual's cells is protected from damage or alterations that can occur naturally or due to external factors, such as radiation or chemicals. Having genome integrity is important for the proper functioning of an organism and for passing on accurate genetic instructions to future generations. Full definition
The DNA repair machinery is vital for the maintenance of genome integrity and for the proper function and survival of all organisms.
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Therefore, effective sensing and repair systems are developed during evolution to eliminate the DNA lesions and to maintain genome integrity.
Multiple studies have reported a link between rDNA stability and cellular aging, as well as the association of proteins involved in genome integrity transiting the nucleolus.
«This collaborative multi-disciplinary effort identifies «mitochondrial genome integrity» as a vital readout in assessing the proficiency of patient - derived regenerative products destined for clinical applications,» adds study co-author Andre Terzic, M.D., Ph.D., Director, Mayo Clinic Center for Regenerative Medicine.
Finally, as we and others have shown, errors in chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and chromosome shattering (chromothripsis).
Likewise, the DDR - mediated pro-inflammatory signals may further alarm the neighboring cells and tissues for the presence of cells with compromised genome integrity.
At PBE2018 Wanda M. Waterworth will give a talk on: «Safeguarding genome integrity in germination and seed longevity»
«Inhibition of cell division in response to DNA damage enables cells to maintain genome integrity.
Defects in nuclear actin polymerization and myosin motor function result in heterochromatin repair defects and widespread chromosome rearrangements, revealing the importance of the relocalization pathway in genome integrity.
To maintain the genome integrity, DNA damages have to be monitored and repaired.
reproductive aging, oocyte dysfunction, telomeres, meiosis, stem cells, oocytes, genome integrity, stem cell biology
Cohesin and cohesin - associated factors and their contribution to genome integrity, chromosome segregation and cell survival
Genome integrity in the mammalian germline: recombination and checkpoints during gametogenesis
She received a position as Chargée de Recherche CNRS in 2001 in the Département Intégrité du Génome (UMR7175 - ESBS, Illkirch, France) directed by Gilbert de Murcia to study the function of PARP - 2 in the maintenance of genome integrity.
Her research activity is focused on the cellular response to DNA damage and genome integrity.
This unique versatility allows scientists to use Tetrahymena to identify several key factors regarding gene expression and genome integrity.
A well - known factor in the decline of stem cell function is the loss of genome integrity, for example, caused by the appearance of somatic mutations.
Julia's lab studies chromosome organization and the maintenance of genome integrity, with mechanisms of telomere function as a springboard.
Furthermore, there is evidence suggesting an association of replication stress on rDNA loci with the aging of hematopoietic stem cells, adding more evidence to the general function of the nucleolus in genome integrity and aging.