Glutathione is created in the body
from glutamic acid, cysteine, and glycine.
GAD stands
for glutamic acid decarboxylase, an enzyme that triggers production of the brain's primary calming chemical, called GABA.
Meanwhile, MSG manufacturers and the FDA say that MSG is harmless, that the allegations of brain problems have never been proven, and that MSG is simply an extract of naturally
occurring glutamic acid which comprises 4.4 pounds of human body weight anyway.
The tRNA that recognizes the codon GAA and encodes for a building block known
as glutamic acid was also elevated in metastatic samples.
The first fact to remember is that many lists of MSG containing foods on the internet mistakenly list foods
with glutamic acid as well.
For individuals who do not respond well to it neurologically, it is due to an inability to
convert glutamic acid to GABA.
Because glutamic acid can not cross the blood brain barrier, where most of the metabolism takes place, glutamine, which can cross this barrier, works better in supplement form.
Yeast is a natural source of umami flavor, or
natural glutamic acid (glutamate).
The autoantibodies commonly produced by people with APECED include one that is a marker of type 1 diabetes,
called glutamic acid decarboxylase autoantibody (GAD).
Moreover, when not immediately available the body
uses glutamic acid to make other amino acids that are necessary for proper protein synthesis, a prime example of chemical exercising firing on all cylinders.
Testing for antibodies
against glutamic acid decarboxylase and antinuclear antibodies was negative.
As you can imagine, being an MSG sufferer for most of my life, I have done quite a bit of research on this topic, and am quite familiar with the link
between glutamic acid and the manufacturing of MSG.
It was back in 1908 when Japanese chemist Kikunae Ikeda proposed umami as a fifth taste — in addition to salty, sweet, sour, and bitter — brought about
by glutamic acid, a compound which naturally occurs in a number foods.
Finally, L - glutamine is turned back
into glutamic acid for the cycle to start again when needed.
When you
eat glutamic acid in real foods, your body controls how much is absorbed.
MSG, however, comes without the natural components of food that help the body
regulate glutamic levels... «The bottom line here is context is everything,» Vollmer adds.»
Vitamin K2 is an essential micronutrient that acts as a cofactor for the γ - carboxylation of
glutamic residues in a number of proteins, including matrix Gla protein (MGP), which, when activated, prevents the calcification of blood vessels (21).
Also is it true that all fermented foods free
up glutamic acid (MSG) and would not they apply to vinegars, fermented vegies, vitamin supplements made from fermentation and yeast?
To create the MIP the researchers searched for a functional analogue of the glutamine precursors of two whiffy molecules and settled on Nα -
hexanoyl glutamic acid.
«When we mutated the GAA codons to GAG — a «silent» mutation because they both spell out the protein building
block glutamic acid — we found that increasing the amount of tRNA no longer increased protein levels,» explains Tavazoie.
Known as EXOSC2 and GRIPAP1, these genes were strongly and directly induced by elevated levels of the
specific glutamic acid tRNA.
German agricultural chemist Karl Ritthausen originally
discovered glutamic acid, of which monosodium glutamate (MSG) is just one variation, in 1866.
Patients with LADA — a form of autoimmune type 1 diabetes in adulthood — can be distinguished from patients with non-autoimmune type 2 diabetes by means of the antibody reaction affinity to the
enzyme glutamic acid decarboxylase (GAD).
(
Take glutamic acid, for instance, which is specified by both GAG and GAA.)
In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies
targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.
Well, proteins are made up of a string of amino acids, and there are some amino acids more common in plants than in animals —
particularly glutamic acid, which a study published in the Journal of the American Heart Association was found, for example, to potentially «have independent [blood pressure]- lowering effects, which may contribute to the inverse relation [between] vegetable protein to [blood pressure],» — meaning high plants; low pressure.
However, in contrasting cycles, glutamine can be directly received from natural sources of the human diet,
whereas glutamic acids are not found in many food items, except for whey protein.
Following digestion, your body
absorbs glutamic acid and transports it to your cells, and then your cells start making and planting amino acids into newly formed protein.
Many times «natural flavor» is used to
identify glutamic acid, which is very similar to MSG.
When glutamic acid combines with ammonia, a waste product of metabolic activity, is converted into glutamine.
Monosodium glutamate is basically a manmade derivative of the common amino acid or
protein glutamic acid.
Then in 1907, a Japanese chemist called Kikunae Ikeda was experimenting with various food flavours to find the ultimate combination, and
isolated glutamic acid from seaweed.
Your body has a tight leash
on glutamic acid from natural food.
In the chemical MSG manufacturing plant the
bound glutamic acid is broken down and made free of protein.
Your body has to break down or
hydrolyse glutamic in the stomach and lower intestines using hydrochloric acid and digestive enzymes.
Apologists for MSG argue that the additive is not really different from glutamate (or its
cousin glutamic acid).
Excitotoxicity is a pathological process
where glutamic and aspartic acid cause an over-activation of your nerve cell receptors, which can lead to calcium - induced nerve and brain injury.
The patients were diagnosed positive for antibodies to the Hepatitis C virus, and showed elevated levels of GPT (
glutamic pyruvate transaminase) and had chronic illness for 3 to 20 years before using Eurocel.
Fortunately, the concentration of glutamate is far lower than factory
produced glutamic acid, aka MSG (monosodium glutamate).