In animal studies conducted at Virginia Commonwealth University Medical Centre, curcumin helped
improve gut barrier function after a poor diet caused inflammation.
Despite our lack of knowledge of its normal role in the gut, zonulin has been used as a biomarker of
impaired gut barrier function in autoimmune, neurodegenerative, and metabolic diseases.
(2) In a recent study
examining gut barrier function, IBS patients had significantly more «gaps» between the cells of the intestine compared to healthy patients.
It increasingly appears that IBS is a multi-factorial condition, with
impaired gut barrier function and / or imbalance of gut flora, disrupted circadian rhythm due to shift work, and elevated levels of psychological stress all potentially impacting the course of IBS.
One study puts it this way: «Glutamine has protective effects on intestinal mucosa by decreasing bacteremia and epithelial cell apoptosis,
enhancing gut barrier function, and influencing gut immune response» [3].
But then, as the animal's immune system began to exercise some control over the virus and
gut barrier function improved, the level of bacteria in the blood declined.
Review:
Gut barrier function: Effects of (antibiotic) growth promoters on key barrier components and associations with growth performance — Leon J Broom — Poultry Science
Stress in itself, in otherwise healthy individuals subjected to intense physical training, has been shown to impair
gut barrier function, (9) likely through effects on the stress hormone cortisol.
However, the evidence pertaining to these factors -
gut barrier function, circadian rhythm, and stress - also suggests that, depending on the factors at work in each individual case, use of select agents can help IBS sufferers control their symptoms naturally.
A maladapted stress response is thought to contribute to IBS flares through several mechanisms, including impaired
gut barrier function, changes in gut flora, changes in gastrointestinal motility and secretion, decreased mucosal blood flow, and decreased ability to heal and recover from damage.
Studies show glutathione may play an important role in
gut barrier function and the prevention of intestinal inflammation.
You need to restore immunity,
gut barrier function, and other parts of your body.
«Crosstalk between the gut microbiota and the endocannabinoid system: impact on
the gut barrier function and the adipose tissue.»
If ICZ activates the AHR (Aryl hydrocarbon receptor in the intestinal lining, it enhances
gut barrier function and inhibits gut lining inflammation).