Sentences with word «hapten»

Random - bred Hartley strain guinea pigs which do not respond immunologically to conjugates of hapten and poly - L - lysine mere mated with heterozygous guinea pigs which do.

To make this work, Janda and his research team designed small molecules called haptens with highly similar structures to the target drugs.

«Normally the immune system mobilizes a mixture of various white blood cells to attack hapten - exposed tissues,» reports Dr. van den Boorn.

If the researchers incapacitated this checkpoint, the monobenzone - induced tyrosinase hapten did not trigger the desired immune reaction anymore.

Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs.

Only when monobenzone docks onto the tyrosinase enzyme, a so - called hapten is generated in the pigmented cell.

Antibody responses to hapten - polypeptide conjugates require peptide - specific helper T cells.

The way in which the animals» immune defense reacted to this hapten amazed the researchers.

Because heroin is too small a molecule to induce antibodies on its own, researchers work closely with organic chemists to create the structural analog (hapten) that is joined to a carrier protein and used in the vaccine.

The haptens were then attached to carrier proteins called epitopes that provide a binding site for antibodies.