Sentences with phrase «high specificity»

In that case, the color of the ink and light can be tuned across a fairly wide spectrum, allowing for shape changes with high specificity.

Single - copy genomic sequences were amplified by a factor of more than 10 million with very high specificity, and DNA segments up to 2000 base pairs were readily amplified.

Ideally, the drug should have a shape that is perfectly complementary to a disease - causing target, so that it binds it with high specificity.

According to our current analysis, prostate volume did not affect the eNose results, potentially indicating high specificity of our sensor array to cancer.

Recent enhancements have expanded its abilities; one example is a new, hyperaccurate Cas9 variant that demonstrates high specificity across the genome without compromising on - target activity in human cells.

The researchers found that BMI has high specificity in identifying pediatric obesity, meaning BMI accurately identifies children who are obese, but has a moderate sensitivity, meaning the BMI tool misses children who actually should be considered obese, according to the percent of fat in their bodies.

The findings indicate that this screening strategy achieves high specificity with very few false positive results in post-menopausal women.

«The fact that their machine - learning approach has such high specificity and sensitivity and is useful at the level of an individual child is truly impressive,» says Charles Nelson, professor of pediatrics and neuroscience at Harvard University, who was not involved in the study.

Ideally, this would involve highly - fluorescent molecules that can bind cytoskeletal proteins with high specificity without being toxic to the cell.

Since its creation in 2009, TEFOR - AMAGEN has conducted research projects in the area of high specificity nucleases to develop targeted transgenesis and genome editing methods.

That is, we are examining whether teachers who report higher specificity, consistency, authority, power and stability in their policy environments are more likely to cover the content emphasized in their state's standards.

However, in the study of Mazefsky et al. (2011), it was also found that the results of the internal reliability of the self - report questionnaire were as good, or better, than those of the standardization samples and that of all self - report measures, the RCMAS (Revised Children's Manifest Anxiety Scale; Reynolds and Richmond 1985) showed the most promise (with rather high specificity and positive predictive values).

The CBCL achieved very high specificity (> 90 %), but generally low sensitivity.

It is validated for use with live or postfixed cells in conjunction with probes, and identifies each stage with high specificity, sensitivity, and convenience.

Although new synthetic drugs are closely evaluated for high specificity, high efficacy, low toxicity, and good pharmacokinetics, little attention is paid to the possibility that the chemically synthesized drugs may eventually be discharged from the human body into the environment in their original and / or metabolized forms.

Unlike other human antibodies under investigation that recognize both Zika and the closely related dengue virus, the antibodies used in this study exclusively target Zika, demonstrating a high specificity that could be important in avoiding potential side effects — such as enhanced dengue infection in regions where both viruses are endemic.

However, this symptom pattern also had «moderate to high specificity» — homotypic symptoms do occur in many patients who go on to develop BD.

The researchers designed and synthesized a novel small molecule PET tracer, 18F - MPG, with high specificity to activating EGFR mutant kinase.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

That data showed that TEE had modest sensitivity (56 percent), but high specificity (100 percent) in identifying intramural VSDs.

At ABclonal, we have nearly 100 existing chromatin immunoprecipitation (ChIP)- validated antibodies with a higher specificity than most commercial antibodies, which are used for a wide range of epigenetics studies, from those investigating developmental processes to those researching various diseases.

The other related genes, DFR - A and DFR - C, were examined and no mutations were found, confirming the high specificity of the CRISPR / Cas9 system.

This high specificity also prevents the bacteriophages from switching to a new host bacterium.

Further evidence of the high specificity that this method of stimulation can bring to human brain modulation has been provided by intraoperative investigations (Histed et al., 2013; Logothetis et al., 2010).

The high resolution structures are the starting point for the design of lead compounds that are endowed with high specificity, and can undergo further development for the design of highly specific, personalized drugs.

Recent studies by Davidson Y et al. have confirmed the high specificity of Proteintech C9orf72 antibodies, highlighting their great value for research and diagnostic purposes.

Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity.

The Clinical Biomarkers Facility offers services for high - throughput and highly specific analyses of protein biomarker candidates in body fluids such as plasma, serum, cerebrospinal fluids etc. and cell and tissue lysates using molecular tools such as proximity extension and proximity ligation technologies (PEA and PLA) providing assays with high specificity and sensitivity in complex biological matrices.

Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski - Rogacz M, Chakraborty D, Beschorner N, Hofmann - Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi - Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F. Directed evolution of a recombinase that excises the provirus of most HIV - 1 primary isolates with high specificity.

The high specificity with one epitope target makes our monoclonal antibodies very efficient, reflecting in less background staining and low cross-reactivity with other proteins.

«This test looks to have a high specificity (although this needs to be tested further in a large population cohort) which could lower the likelihood of false positives, a key potential issue with screening aside from cost and uptake.

No cross reaction was observed demonstrating the high specificity this assay.

Due to the serious side effects caused by the activation of the pharmacologically and structurally closely related subtypes, it is essential that 5 - HT2C agonists developed for clinical use have a high specificity and subtype selectivity.

In addition, sema1a levels were unaffected, demonstrating the high specificity of RNAi (not shown).

To accomplish this, Xie's group has developed several strategies to achieve single - molecule sensitivity with high specificity, millisecond time resolution, and nanometer precision in living cells.

Also called immunoglobulins, antibodies can bind their targets with high specificity.

However, advanced imaging can be an invaluable tool to assist clinicians in the evaluation of patients for possible aortitis with high specificity, and sensitivity [4].

Thanks to very high specificity, this higher than expected dose does not appear problematic, and several ligands are suitable candidates for further development.

In the appropriate clinical setting, suspicion for acute aortic dissection should be raised when patients present with findings that have a high specificity and high positive likelihood ratio (hypotension, pulse deficit,...

Using sazetidine - A as a template, medicinal chemists developed multiple series of novel ligands with modifications to the pyridine core, azetidine ring, and alkynyl side chain with the objective of designing α4β2 - nAChR partial agonists of high specificity.

These activities have the highest specificity to rugby for all positions and are extremely important no matter where you are on the pitch.

The research shows that antibody blood tests with high specificity and sensitivity are tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP).

The high specificity in states» efforts to implement standards - based reform can be attributed to the nearly all states providing CCR - aligned curricular frameworks for general education students, ELLs, and SWDs by 2016.

Gadoxetate disodium (Gd - EOB - DTPA; gadolinium - ethoxybenzyl - diethylene triamine penta - acetic acid) is a newly developed paramagnetic contrast agent reported to have a high specificity for the hepatobiliary system in humans.

«In our latest study, we combined the highly efficient light harvesting of an inorganic semiconductor with the high specificity, low cost, and self - replication and self - repair of a biocatalyst,» Yang says.

Demonstrated knowledge and ability to assign ICD - 9 CM codes to the highest specificity ensuring that diagnostic codes and documentation accurately reflect and support the visit encounter.