Sentences with phrase «histocompatibility complex»
The phrase "histocompatibility complex" refers to a group of genes in our body that helps our immune system determine if something is a friend or a foe. It provides a way for our immune system to recognize and distinguish our own cells from foreign cells, such as viruses or bacteria. It plays a crucial role in organ transplantation as it helps in matching the donated organ to the recipient to prevent rejection. Full definition
When the team looked at what gene signatures the RORγt - dependent ILCs expressed, they found high expression of major histocompatibility complex class II (MHCII) protein, which some cells use to display foreign proteins to the immune system and directly interact with T cells.
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They've been bred to lack proteins — members of a family called MHCI (which stands for major histocompatibility complex class I)-- crucial to fighting pathogens.
This haplotype has sequence similarities to human major histocompatibility complex alleles associated with susceptibility to type 1 diabetes (89).
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice
She received her Ph.D. in Biochemistry from the University of Wisconsin - Madison and was a postdoctoral fellow at The Scripps Research Institute and the University of Dundee, Scotland, where her research focused on the intracellular transport of major histocompatibility complex molecules and invariant chain.
The association between canine diabetes and the major histocompatibility complex in a heterogeneous population strongly suggests that both a genetic predisposition and the immune response have roles in the pathogenesis of diabetes in dogs (84).
Association of hypothyroid disease in Doberman Pinscher dogs with a rare major histocompatibility complex DLA class II haplotype.
Thymic major histocompatibility complex antigens and the αβ T - cell receptor determine the CD4 / CD8 phenotype of T cells.
Unconventional T cells are defined by their capacity to respond to signals other than the well - known complex of peptides and major histocompatibility complex proteins.
The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin - like repeats
Class II Major Histocompatibility Complex Transactivator (CIITA) Inhibits Matrix Metalloproteinase - 9 Gene Expression
This in turn suggested that the genes controlling their immune system's responses (located in the major histocompatibility complex [MHC]-RRB- might be responsible for the side effects they were experiencing.
Major histocompatibility complex haplotypes (Kennedy et al. 2006) and cytokines (Short et al. 2009; Short et al. 2007) have also been implicated in canine diabetes.
Reduced genetic diversity of the major histocompatibility complex also does not correspond to lowered immune competence [34, 35].
Human type 1 diabetes is principally a disease of Caucasians, and the major genetic susceptibility is linked to the major histocompatibility complex alleles on the leukocyte antigen gene on chromosome 6p, although many other genes contribute (74).
HLA - B7 and β2 microglobulin are components of major histocompatibility complex class I (MHC - I), expression of which is often altered during cancer progression, allowing tumor cells to evade the immune system.
Major histocompatibility complex genes, symmetry, and body scent attractiveness in men and women.
Additionally, the proteasome regulates cell - cycle, antigen processing through class I major histocompatibility complex molecules, gene expression, and cell signaling (43).
Evidence is mounting for a genetic basis for canine diabetes, and the association with the major histocompatibility complex alleles on the dog leukocyte antigen gene strongly suggests that the immune response has a role in pathogenesis.
In this case what is being sensed is the Major Histocompatibility Complex.
The molecule in question, known as beta - 2 microglobulin, or B2M, is a component of a larger molecule called MHC I (major histocompatibility complex class I), which plays a major role in the adaptive immune system.
The findings do not support earlier contentions that genes for T - cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).
Individual body odor is influenced by genes, and by one group in particular: the genes that determine which proteins combine to form your unique major histocompatibility complex (MHC).
A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL / 10 mouse.
The major histocompatibility complex (MHC) is a region of DNA vital to the immune system.
Burger et al. showed that cryptic female choice may play a role in a well - known mechanism of mate choice, major histocompatibility complex (MHC) matching.
A team led by neuroscientist Carla Shatz was running a routine procedure designed to identify genes regulated by neuronal firing when an unexpected one popped up that codes for major histocompatibility complex (MHC) class I molecules, which play a crucial role in helping the immune system recognize invading pathogens.
Major histocompatibility complex class II (MHC II) molecules capture peptides within the endocytic pathway to generate T cell receptor (TCR) ligands.
In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.
Yet of maybe even greater gene - spreading significance is the ability to tell differences in MHC — the major histocompatibility complex, a gene family linked to the immune system and body scent.
Host genes of the major histocompatibility complex (the genes that determine how mammals respond to pathogens) play a significant role in how the immune system responds to all pathogens.
Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.
The region of chromosome 20 associated with sarcoid development is within a portion of the genome responsible for immune function called the Major Histocompatibility Complex (MHC) class II region.
How it hides: In a normal cell, genes encode instructions for surface proteins known as the major histocompatibility complex (MHC).
These molecular identity cards are produced by a set of genes collectively known as the major histocompatibility complex, or MHC.
Antigens are exposed on the surface of DCs in a protein complex along with major histocompatibility complex (MHC) proteins that mediate the recognition and activation of the appropriate T cell subtype.
To this aim, the researchers incorporated molecules into the scaffolds that are known as the major histocompatibility complex (MHC) and that presented small peptides derived from viral proteins to T cells.
Researchers from Princeton University and the University of California - San Diego (UCSD) recently found that an immune - system protein called MHCI, or major histocompatibility complex class I, moonlights in the nervous system to help regulate the number of synapses, which transmit chemical and electrical signals between neurons.
They looked specifically for genes coding the major histocompatibility complex (MHC)-- a molecule found on the surface of cells that acts as a crucial component of the immune systems of most vertebrates.
The immune system recognizes transplanted organs as foreign tissue by telltale proteins, called the major histocompatibility complex (MHC), that coat cell surfaces.
The team discovered each animal emits an intense odor that broadcasts the chemical composition of what is known as their major histocompatibility complex, or MHC, genotype.
It is the latest twist in the tale of the major histocompatibility complex, a set of immune system genes that influences mating preferences.
This will cover a pilot project in a small region — about 1/1000 of the human genome — containing the genes for the major histocompatibility complex (MHC), proteins that present snippets of pathogens to immune cells.
Another tantalising finding is the involvement of the major histocompatibility complex — a key part of the immune system — in influencing how susceptible people are to mental illness.
Scientists from UEA and Dalhousie University studied how Guppy fish (Poecilia reticulata) adapt to survive by studying their immune genes, known as the Major Histocompatibility Complex or MHC genes.
A. I was working for Peter Parham who works on the Class I gene of the Major Histocompatibility Complex.
The key appears to be a suite of genes that include the major histocompatibility complex (MHC), which initiates immune response and ultimately provides disease resistance.