Sentences with phrase «host factors»

This process involves interactions with cellular host factors as well as virus - virus interactions.

Identifying these interacting host factors can provide insights into the critical regulatory steps during the infectious process.

His technical publications included a study of host factors in pituitary chromophobe adenoma, in Metabolism, and an essay on medical obfuscation in the New England Journal of Medicine.

To clarify the respective roles of rabbit PrPC and non-PrP host factors in the rabbits» pronounced but not absolute resistance to TSE, they created transgenic rabbits that have both sheep and rabbit PRNP genes and tested their susceptibility to TSE.

«We have now identified an essential host factor which when removed prevents all parasite strains from entering red blood cells.»

These and other ethical, legal and social challenges need to be considered when designing and conducting genomic research on host factors and host - vector - pathogen interactions in Ebola virus disease.

Hsiaohsuan is now studying host factors involved in HIV latency and establishment of the viral reservoir.

Many drugs that target rotavirus viroplasms — centers of viral replication and assembly — target host factors, like microtubule assembly or proteasome activity.

Developing a focus on the sick child, which has provided a new understanding of how different bacterial, parasitic and viral infections interact with host factors such as nutrition and genetic factors.

Disease - causing viruses engage their hosts in ongoing arms races: positive selection for antiviral genes increases host fitness and survival, and viruses in turn select for mutations that counteract the antiviral host factors.

«Besides host factors [such as low immunity to the virus in affected communities], there are definitely some other unknown viral proteins or amino acids that may contribute to the complex pathogenesis of microcephaly — independently or synergistically,» says lead author Chen - Feng Qin, chair of the Department of Virology at the Beijing Institute of Microbiology and Epidemiology.

«The discovery of CD55 as an essential host factor for P. falciparum raises the intriguing possibility of host - directed therapeutics for malaria, as is used in HIV,» said Egan.

«Our study shows that we can use this new CRISPR / Cas9 gene - editing technology to render mosquitoes malaria - resistant by removing a so - called host factor gene,» says study senior author George Dimopoulos, PhD, professor in the Bloomberg School's Department of Molecular Microbiology and Immunology.

Although this study represents only a single case, it provides unprecedented detail on the host response to Ebola virus disease and may inform the development of therapeutics designed to boost or accelerate host factors that most effectively counter the virus and promote healing.

«This study identifies PHB as the first host factor that is specifically involved in EV71 infection of the CNS,» the authors further explain.

Overbaugh offered congratulations and said Sharma is tackling a «high risk, high payoff» project: identifying new interferon - induced host factors that restrict HIV replication.

The viral DNA was purified along with the bound host factors, which subsequently were identified using mass spectrometry.

«For example, we might be able to create combination microbicides that include agents targeting both the virus and host factors promoting infection.

Colonization is driven by the ecology of the skin surface, which is highly variable depending on topographical location, endogenous host factors and exogenous environmental factors.

We have turned our attention to studying possible host factors that contribute to the risk of bone sarcoma development.

Little is known about how gonadal hormones or other host factors regulate sarcomagenesis.

The purpose of our study was to determine if specific host factors, such as age at diagnosis, obesity, and hormone status, influence the prognosis of canine mammary gland carcinomas and to confirm if previously reported risk factors (ie, histologic subtype, tumor size, and World Health Organization [WHO] stage) were important in a large series of affected dogs.

Influence of host factors on survival in dogs with malignant mammary gland tumors.

Kass, PH, Peterson ME, Levy J, James K, Becker DV, Cowgill LD: Environmental, nutritional, and host factors in cats with hyperthyroidism.

FREP1 is thus considered a malarial «host factor.»

In future studies, the team plans to use the model to better understand how microbes, host factors and inflammatory markers interact to produce the hallmarks of inflammatory disease in the intestine.

The elimination of this host factor via the deletion of the FREP1 gene had other effects besides reducing the number of mosquitoes infected with malaria.

In addition, he and his team are using their CRISPR / Cas9 DNA - editing platform to study the effects of deleting other potential malaria host - factor genes and to learn more about the roles of these host factors in mosquitoes.

They also offered advice to researchers who are considering live imaging as an evaluation tool; for example, how the reporter virus is designed could affect its virulence, and host factors, such as inflammation, could affect detecting the luminescent signal.

The team will now analyze examples of norovirus infection within the families of the symptomatic carriers, and use this data to identify the virus factors and host factors that are key in converting the norovirus infection from asymptomatic individuals to symptomatic infections.

This is important, as previous work has shown that host factors and cells in the seminal fluid activate cells in the female reproductive tract and enhance HIV infection, yet the underlying mechanisms remain poorly understood.

This is ascribed to «resistance,» suggesting that germs are less important in disease than other factors affecting the condition of the host

Understating the interplay between the complex oral microbiome and host factors (e.g. immune factors) in childhood caries (i.e. tooth decay)

While there is ongoing debate regarding the contribution of different mechanisms in dengue illness, there is substantial evidence supporting both viral and host factors in disease pathogenesis.

The investigators uncovered a number of host factors that were deactivated by early viral proteins and identified a subgroup of nucleolar proteins that aid virus replication.

To do this, a team led by Matthew Weitzman of the University of Pennsylvania crosslinked the host factors of infected human cells with the DNA of adenovirus, herpes simplex virus and vaccinia virus.

When a virus enters a host cell, its genome interacts with a myriad of host factors to promote viral gene expression, DNA replication and virion assembly.

biological agents (such as viruses and bacteria), host factors (such as obesity, co-morbid conditions, and age), and behaviors (such as dietary intake) that may cause or contribute to the development of cancer

The localized expression of these and other PGRP family members (Figure 2C) suggest that the microbiome interacts with enterocytes in a highly organized way and that some bacterial species may be localized to specific regions of the gut lumen by the selective expression of host factors.

During his PhD under the supervision of Drs. Luis Enjuanes and Fernando Almazan at the National Centre of Biotecnology (Madrid, Spain), he studied the mechanism of replication and transcription of coronavirus and the role of host factors that modulate these processes.

Kass, PH, Peterson ME, Levy, JK, James, KM, Becker DV, Cowgill LD: Evaluation of environmental, nutritional, and host factors in cats with hyperthyroidism.

This study assumes that socio - emotional development of infants would be equally affected by different factors among which is type of feeding in addition to other factors such as micronutrient adequacy, demographic factors (as maternal education and socioeconomic status), and host factors (as child order of birth).