Sentences with phrase «host genome»

«After emerging some 420 million years ago, KZFPs evolved rapidly in a lineage - specific fashion, parallel to the invasion of host genomes by transposable elements,» says Trono.

That conversation, and the subsequent reading, motivated him to learn about the rogue genetic elements — transposons — that duplicate themselves within host genomes.

«Host genome controls skin microbiota and inflammation.»

Lee Arnold of the American Kennel Club and Canine Health Foundation Boards of Directors hosts Genome Barks, an AKC - sponsored series of podcasts.

These elements insert themselves into the host genome using two enzymes that they encode for themselves: an endonuclease that cleaves the host chromosome in a specified location, and a reverse transcriptase that copies the retrotransposon's DNA back into the host genome.

However, viral integration into the host genome increases the risk of tumorigenicity.

In a recent study published in the journal Nature Communications on 17 September, John Baines, Saleh Ibrahim and their colleagues of the Inflammation Research Excellence Cluster show that composition of skin microbiota is controlled by the host genome and that skin bacteria may have a greater influence on inflammatory diseases than previously thought.

John Baines: «It appears that the skin flora is a phenotype that is partially controlled by the host genome variations.

The researchers also believe that their vaccines would be safer than DNA vaccines, another alternative that scientists are pursuing, because unlike DNA, RNA can not be integrated into the host genome and cause mutations.

The preferred methods generally involve infecting tissue with Agrobacterium — a bacterium that naturally transfers DNA to its host genome — and then stimulating that tissue to regenerate into whole plants.

Unfortunately, as the paper shows, especially the action of family member APOBEC3A can spill over from its attack against viruses to induce DNA mutations and damage in the host genome as well.

«The presence of the PAM adjacent to target sites in foreign DNA and its absence from those targets in the host genome enables Cas9 to precisely discriminate between non-self DNA that must be degraded and self DNA that may be almost identical.

This «self - inactivating» retrovirus also can not make more copies of itself once it has stitched itself into the host genome.

These cells relied on a protein called cyclic GMP - AMP synthase (cGAS) to sense the viral DNA in the cytosol before the foreign DNA became integrated into the host genome.

Finally, the transfer plasmid encoded the desired transgene flanked by HIV - 1 long terminal repeats (LTRs) that facilitate viral packaging and host genome integration.

HBV integration into the host genome has been reported but its scale, impact and contribution to HCC development is not clear.

These «parasitic» DNA elements, called transposons, can jump and multiply within a host genome and have played an active role in animal evolution, facilitating genetic variation and adaptation.

HGD is divided into three main divisions: BeeBase, which hosts bee genomes and the Bee Pests and Pathogens resource; NasoniaBase, which hosts the genome of the Jewel wasp (Nasonia vitripennis); and the Ant Genomes Portal, which hosts the genomes of several ant species.

The next step is to gain more information about which genes the microbes are carrying and how they're interacting with the host genomes.»

But their activity represents a threat to the host genome and thus they are almost always actively repressed, or silenced, by various proteins and regulatory RNAs produced by the host genome.

But when these repaired stem cells are given back to patients, they can include transgenes — unwanted genes that have become inserted into the host genome and disrupt the normal function of DNA.