The phrase
"hypertensive rats" refers to rats that have high blood pressure, which is a condition where the force of blood against the walls of their blood vessels is too high.
Full definition
Studies
in hypertensive rats provide evidence to suggest that protein from fish is more effective at lowering blood pressure than casein over a 2 mo period (44), and a meta - analysis of adult human trials revealed that n — 3 FAs were effective at improving PWV by 0.33 m / s (39).
In one study performed
on hypertensive rats, rats given an acetic acid solution in addition to a standard diet for 6 weeks showed a 15 - 25 % reduction in systolic blood pressure as compared to rats not given the acetic acid solution.
A peer reviewed study published in 2016 was titled «Renoprotective effect of virgin coconut oil in heated palm oil diet -
induced hypertensive rats.»
Interestingly, a previous study by the research group with a different type
of hypertensive rat found that that ablating the other nerves, the afferent ones, lowered blood pressure.
Animal studies show naringin supplementation improved hypertension in high - carbohydrate / high - fat - diet — fed obese rats and stroke - prone hypertensive rats [1].
Animal studies have shown that
hypertensive rats respond positively to theanine supplementation, successfully reducing their blood pressure11, 12.
But these studies were in rats bred to be
hypertensive rats who need cholesterol to mitigate the rigid membranes they are born with.
The researchers found that coconut oil combined with exercise training reduced body weight, reduced blood pressure
in hypertensive rats, improved baroreflex sensitivity, decreased lipid peroxidation, and reduced superoxide levels.
A peer reviewed study published in 2016 was titled «Renoprotective effect of virgin coconut oil in heated palm oil diet -
induced hypertensive rats.»
A 2011 study published in the Journal of Agricultural and Food Chemistry, tested the impact of pea protein powder on
both hypertensive rats and humans.
A study published in the journal Applied Physiology, Nutrition, and Metabolism found that coconut oil supplementation and physical exercise improved high blood pressure and oxidative stress in
hypertensive rats.
The adrenaline - forming enzyme (phenylethanolamine N - methyltransferase) was elevated in the A1 and A2 regions of the brainstem of 4 - week - old spontaneously (genetic)
hypertensive rats and in the A1 region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats.
They found that disrupting the afferent nerves did not lower high blood pressure in
hypertensive rats.
Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously
hypertensive rats.
Because of the polygenic nature of hypertension, numerous rat models have been developed including selective bred homozygous
hypertensive rat strains (e.g. spontaneously hypertensive rat [SHR] and Dahl salt sensitive [Dahl SS]-RRB- and outbred strains (e.g. Sprague Dawley) to elucidate the desired hypertensive phenotype.
The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in
hypertensive rats.
The hypertensive rats were given pumpkin seed oil or the antihypertensive medication amlodipine every day for 6 weeks.
LA was also associated with beneficial effects on the cardiovascular system due to its ability to increase the high - density lipoproteins and to reduce the blood pressure and heart rate in both normotensive and
hypertensive rats.
In addition, when spontaneously
hypertensive rats, which are often used as a genetic model of the metabolic syndrome, were fed a diet supplemented with 200 mg EGCG · kg − 1 · d − 1 for 3 wk, insulin sensitivity increased (10).
Elkayam A1, Peleg E, Grossman E, Shabtay Z, Sharabi Y. «Effects of allicin on cardiovascular risk factors in spontaneously
hypertensive rats.»
Tyrosine is thought to reduce blood pressure by stimulating catecholamine synthesis in the brain (13), whereas histidine has been shown to inhibit vascular expression of the angiotensin converting enzyme mRNA in
hypertensive rats (9).