Sentences with phrase «immune effectors»
"Immune effectors" refers to the cells and molecules in our immune system that fight against harmful invaders like viruses, bacteria, and other foreign substances. These effectors play a crucial role in protecting our body from infections and diseases. Full definition
Effector and target modules together form a novel platform which allows us to engage target cells (e.g. tumor cells, virus infected cells) directly with immune effector cells.
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Innate immune effector cells, including natural killer cells, macrophages, and dendritic cells, have been shown to interact with cancers and inhibit their progression.
In order to assess whether previously uncharacterized but highly - induced genes represent novel immune effector molecules, we assessed which and how many of these genes encode proteins that possess properties common to known AMPs.
Removing one immune effector element only reveals the presence of an ancillary pathway for allograft rejection.
Apoptosis has been implicated as a T cell - dependent immune effector mechanism in various forms of organ graft rejection (29 — 31).
Our major goals are to develop and optimize novel tools for retargeting of immune effector cells.
Thus in order to cross this important immune barrier fungal pathogens have developed highly sophisticated means to inactivate and block activation of this central innate immune defense system and to inhibit the action of newly generated immune effector compounds.
The «kick - and - kill» paradigm is aimed at combining latency reversing agents (LRA) with immune effectors, such as T - cells, to wake up the virus and kill the reactivated cells.
Although antimicrobial peptides are not the only functional class to be overrepresented among short, secreted proteins encoded by members of multi-gene families, the prevalence of these properties among induced genes strongly suggests the possibly that at least some of these genes encode novel immune effectors.
The immune effector response is sub-optimal because tumors develop multifactorial strategies to escape immune deletion 181, 182.
Even though we can not definitively assign these genes an immune effector role, it is apparent that defensin - like peptides have an unusual diversity in Nasonia, representing 18/34 (52.9 %) homology - annotated AMPs and 6/14 (42.9 %) of putative novel AMPs.