Immunosuppressive therapy is a treatment that weakens or suppresses the body's immune system. It is used to prevent the immune system from attacking healthy cells in conditions like organ transplantation or autoimmune diseases.
Full definition
In each patient, researchers at University of California, San Francisco, transplanted 75 million neural stem cells into each of four sites in the brain and followed that
with immunosuppressive therapy so the recipient wouldn't reject the foreign cells.
«This new approach to delivering immunosuppressant therapy suggests that local delivery of the drug to the grafted tissue has benefits in reducing toxicity, as well as markedly improving therapeutic outcomes, and may lead to a paradigm shift in clinical
immunosuppressive therapy in transplant surgery,» said Jeff Karp, PhD, Division of Biomedical Engineering, BWH Department of Medicine, co-corresponding study author.
The type, intensity and duration
of immunosuppressive therapy contribute to the risk of developing skin cancer, such as melanoma, after transplantation.
It is approved by the U.S. Food and Drug Administration (FDA) for treating certain types of leukemia and is helpful in other conditions that
require immunosuppressive therapy.
Luznik says that the researchers» next step will be to test the short course therapy in a phase III randomized clinical trial that would directly compare results in patients who receive the cyclophosphamide treatment with those who receive either a separate, experimental approach to prevent GVHD or the more traditional six -
month immunosuppressive therapy.
All of the patients who were treated had persistent severe or life - threatening symptoms related to myasthenia gravis (MG), although they had used
intensive immunosuppressive therapies.
«A noninvasive urine test to accurately monitor the risk of kidney rejection could dramatically reduce the need for biopsies and possibly enable doctors to safely
reduce immunosuppressive therapy in some patients,» said NIAID Director Anthony S. Fauci, M.D. «The results of this study support the further development of noninvasive tests for the detection and management of transplant rejection.»
«Further research will reveal whether these antibodies are the mark of a clinically relevant subset of patients and, if so,
whether immunosuppressive therapies can effectively treat children with these debilitating illnesses.»
In theory, the developing fetus with an immature immune system should be a prime target for successful transplantation, since the risk of graft rejection is low and the need for long -
term immunosuppressive therapy may be avoided.
Organ rejection is minimized with this technology because the resulting 3D - printed heart is made from the recipient's own cells, and the need for
extensive immunosuppressive therapy is eliminated.
As I
began immunosuppressive therapy, I was told by specialists that I would not have a normal life: it would be filled with medical treatments, disability, a «high likelihood of early mortality» and «no chance of a normal life.»
Whatever the cause, the patients who received the bone marrow cells have remained stable 1.8 to 5.2 years after withdrawal
of immunosuppressive therapy.
Medications and treatments that can increase the risk include oral corticosteroids, inhaled steroids (used for asthma and other respiratory conditions), chemotherapy, radiotherapy to the head and neck,
immunosuppressive therapy for an organ transplant, antibiotics, and any medication that results in a dry mouth.
Ildstad and her colleagues report that five of eight people who underwent the treatment were able to stop
all immunosuppressive therapy within a year after their kidney and stem - cell transplants, four of which came from unrelated donors.
Even with
immunosuppressive therapy, 10 to 15 percent of kidney recipients experience rejection during the first year after transplantation.
The next step would be
immunosuppressive therapy, which could slow down viral replication by limiting the T cell activation and prevent the CD4 + T cells from committing suicide.
The trial will attempt to further assess the effectiveness of the technique and identify any long - term risks associated with
immunosuppressive therapies.
A treatment plan may include red blood cell transfusions, intravenous immune globulin to strengthen the immune system, an iron - rich diet or iron supplements, exchange transfusions to replace damaged blood with fresh blood, surgery,
immunosuppressive therapy, or partial exchange transfusions to slowly remove and replace a large portion of a patients blood volume.
Immunosuppressants are introduced into the recipient's body to impede organ rejection, but
immunosuppressive therapy can increase the risk of infection and other harmful conditions.
Adult - onset demodicosis is associated with systemic diseases (e.g. hyperadrenocorticism, hypothyroidism, diabetes mellitus, neoplasia) or with
immunosuppressive therapies.
Polyarthritis is a group of diseases that are not usually recognized as infectious, but are extremely responsive to
immunosuppressive therapies.
It may take 2 to 4 weeks for the retinas to reattach, most vision returns, the fundus ultimately illustrates minimal scarring, and
the immunosuppressive therapy is very slowly tapered, and in most cases, eventually stopped altogether.
Additionally, to help suppress her immune system from attacking her own cells further, Bella was placed on
an immunosuppressive therapy of medications.
Immunosuppressive therapy may be considered if additional treatment is needed.
However,
immunosuppressive therapy can increase the risk of infections, especially for dogs with megaesophagus who are already prone to developing aspiration pneumonia.
Pregnant women or people who are immunodeficient (someone who is undergoing
a immunosuppressive therapy, such as for cancer or organ transplant) are at the highest risk.
Latent infections may be reactivated by: stress,
immunosuppressive therapy, complement depletion, and serious concurrent disease.
Management of the disorder may include continuing the medications from treatment in order to protect the remaining stomach lining, and
immunosuppressive therapies may be considered to prevent further damage.
For patients that respond quickly to
immunosuppressive therapy and do not need repeated transfusions, prognosis can be good.
Treatment depends on the type and severity of IBD and frequently involves diet changes, vitamin supplementation, antimicrobial or
immunosuppressive therapy.
If no underlying cause can be detected, or if the disease is determined to be primary or idiopathic AIHA,
immunosuppressive therapy will be used.