Sentences with phrase «in glioma»

Hypoxia, very low levels of oxygen in glioma, plays a crucial role in resistance to radiotherapy because oxygen must be present for optimal fixation of DNA damage induced by ionizing radiation.

Despite the profound effect of hypoxia in compromising the effectiveness of radiotherapy, techniques to directly and repeatedly quantify oxygen levels in glioma in order to develop optimal hyperoxic strategies are lacking.

In a new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer stem cells in a glioma cell line, a model of a highly aggressive type of brain cancer.

Nakano says UAB will be the only site in the Deep South for this unique trial aimed at a molecular target in glioma stem cells, a target that is different from the ones described in the Cancer Research paper.

«Single - agent protein kinase inhibitors have had disappointing clinical results in gliomas due to limited brain penetrance and drug resistance,» the study said.

Gαs went from lipid rafts to nonraft regions of the plasma membrane in the glioma cells, which enhanced its signaling ability.

«This could be a universal mechanism for enhancing efficacy of immunotherapies in glioma,» she says.

«The field of targeted therapies in gliomas holds a lot of promise, and IL13Rα2 is in an optimal position to materialize these promises,» explained corresponding author Sadhak Sengupta, PhD, assistant professor of neurosurgery at BUSM and principal investigator of the Brain Tumor Lab at Roger Williams.

Investigators at Dartmouth have extensive Shared Resources available for research and this team used the Pathology Shared Resource to evaluate cell cycle distribution in the glioma.

These results indicate that further investigations of the role of these three genes in glioma development would be of interest, with potential benefit to both dogs and humans.

It's particularly because components of the citric acid cycle, specifically isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have recently emerged as oncogenes that are recurrently mutated in gliomas and leukemias.

Brain cells are highly plastic, and this plasticity translates in glioma into extreme genetic heterogeneity and a pro-invasive predisposition; this combination of continual evolution and rampant spread are what makes glioma so difficult to treat.

University of California - San Francisco Combination therapy against EGFR and PI3 - kinase in glioma

Finally, the study by Vera et al4 «demonstrates the power of combining clinical and molecular assessments in glioma studies to identify novel mechanisms underlying patient symptoms and toxicities for risk - stratification and interventions to improve patient outcomes.»

His work in cancer genomics research spans multiple cancers, with published work in glioma, lymphoma, leukemia, breast cancer, ovarian cancer, and sarcoma.

«This provides exciting opportunities to evaluate and optimize various strategies being developed to improve oxygen levels in the glioma.»

«Implantable micro-device to monitor oxygen in glioma to improve treatment outcomes.»

It was reported, for example, that CSC state could be maintained by overexpressing hypoxia - inducible transcription factor (HIF2α) in glioma cell lines [40].

Khan's team set out to implement in vivo EPR oximetry using a method that employed implantable resonators for repeated measurement of oxygen levels in the glioma, and developed strategies to increase the levels to improve treatment outcomes.

Looking forward, Khan's team plans to investigate treatment outcomes when radiotherapy is scheduled at times of an increase of oxygen levels in glioma.

Improving the level of oxygen in gliomas will have a proven positive affect on treatment outcomes.

«Real - time knowledge of oxygen levels in gliomas will be extremely useful in developing oxygen guided optimal treatment plans for each patient in the clinic.»