Sentences with phrase «in laboratory mice»

Although the gene / cell therapy strategy was highly successful in laboratory mice, the authors stressed that additional research and testing are needed before the therapy could be tested in humans.

Researchers have developed a vaccine for preventing allergic reactions to peanuts in laboratory mice.

Similarly, even in laboratory mice and rats, nicotine usually fails the reinforcement test, with animals choosing a placebo over nicotine.

Let's say you know how a particular chemical is harmful; for example, that it has been shown to interfere with cell function in laboratory mice.

The technique has already been shown successful in laboratory mice.

Rutgers scientists have discovered that a protein which is supposed to prevent cell damage is not working efficiently in laboratory mice with heart and liver disease.

Influence of intermittent fasting and high - fat diet on morphological changes of the digestive system and on changes of lipid metabolism in the laboratory mouse

The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

In research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humans.

A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome (AS)-- a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.

A team of neuroscientists has identified a modification to a protein in laboratory mice linked to conditions associated with Alzheimer's Disease.

Loss of an enzyme that modifies gene activity to promote brain regeneration may be partly responsible for age - related cognitive decline, according to new research in laboratory mice by UC San Francisco scientists, who also found that restoring the enzyme to youthful levels can improve memory in healthy adult mice.

The second was the existence in laboratory mice of a large mutation called an inversion that affects several million nucleotides near the KITLG gene.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

Investigators found that by limiting an amino acid called asparagine in laboratory mice with triple - negative breast cancer, they could dramatically reduce the ability of the cancer to travel to distant sites in the body.

Moreover, in separate experiments conducted in the United States, treatment with antimalarials did not affect survival in laboratory mice infected with Ebola virus.

Two gut pathogens commonly found in malnourished children combine to worsen malnutrition and impair growth in laboratory mice, according to new research published in PLOS Pathogens.

The researchers next tested and confirmed their clinical findings in laboratory mouse models of asthma, and produced data suggesting that targeting the VNN - 1 pathway therapeutically might be a way to improve outcomes for difficult - to - treat asthmatic children.

Padraic Fallon and Michael Doenhoff at the University of Wales, Bangor, found that S. mansoni in laboratory mice could develop resistance to praziquantel when the animals were given regular low doses of the drug.

The researchers have demonstrated positive results in laboratory mice, and have shown that the spread of cancer even on a very small scale can be detected earlier than with traditional techniques such as magnetic resonance imaging or near - infrared imaging.

But the process can be halted in laboratory mice, he adds.

In the Rutgers study, Zong and lead author Ji - An Pan, a scientist in his laboratory, looked at liver and heart damage in laboratory mice and found that the mice in which the TRIM21 gene was inactivated suffered little heart or liver damage when put through the same laboratory procedures used to produce tissue damage in mice with the gene.

Shiitake mushrooms have been researched for their medicinal benefits, most notably their anti-tumor properties in laboratory mice.

Researchers found that by using specific frequency of light to modulate a very small region of the brain called the anterior cingulate cortex, or ACC, they could considerably lessen pain in laboratory mice.

Although the research was done in laboratory mice, the findings have possible implications for human stem cell transplants.

The researchers investigated how CD8 + T cells in laboratory mice respond to infections.

Researchers in the Cedars - Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents.

By fusing a cat protein and human protein, researchers have successfully blocked cat allergies in laboratory mice.

The researchers note that more work and evaluation is needed for definitive results, and they hope to improve and expand upon the method of using natural microbiomes in laboratory mice.

To better understand the origins of obesity and this associated syndrome, Dr. Verdin and his colleagues deactivated, or turned off, the SIRT3 gene in laboratory mice.

A similar technique has been pioneered in laboratory mice by Island Conservation's genetic biocontrol initiative.

BUFFALO, N.Y., March 21, 2017 / PRNewswire / — Today, a research team from Everon Biosciences, Inc. and the Roswell Park Cancer Institute has published a new study describing a methodology for determining a physiological frailty index (PFI) as a measure of biological age in laboratory mice.

CNR Monterotondo Workshop on Cryopreservation and Recovery Techniques in the Laboratory Mouse, November 07 - 10, 2016

A fundamental understanding of many biological processes in humans has stemmed from experimental studies in animal models, particularly in laboratory mice.

Researchers recently performed experiments to determine if dietary fiber deprivation can promote mucus - eroding microbiota in laboratory mice.

(It's relatively easy to cure cancer in laboratory mice — «If you can't cure cancer in a mouse,» a cancer researcher once said to me, «then you should change careers» — but certainly not easy in people.

Surani wanted to test whether mammalian parthenogenesis was possible by trying to create a «virgin birth» in laboratory mice.

Further, in laboratory mice, the team found that by deleting this substance, they could produce the type of scarring found in pulmonary fibrosis after lung injury.

In his laboratory mice, Dr. Ding has now used chemical reprogramming to turn fibroblasts into neural «precursor» cells with the potential to become new oligodendrocytes.

Working in laboratory mice, they injected the most abundant of these small RNAs into the mouse brain to assess the impact of each on brain development, including whether they caused microcephaly.

In laboratory mice, this extends lifespan a few weeks because they are not allowed to die from cancer, but are sacrificed when tumors reach a specific size.