Sentences with phrase «in other cancers»

They are especially prevalent in blood cancers such as lymphoma but occur in other cancers as well.

Apart from this research, the drug is also being studied in other cancers, such as triple - negative breast cancer and pancreatic cancer.

He found that not only did the genes act the same in certain breast cancers but the gene similarities were active in other cancers as well.

The study also may have broader implications for how clinicians approach the development of such treatments and understand mechanisms behind resistance to treatment in other cancers.

In the others the cancer growth was only delayed.

These drugs have been used to treat melanoma and lung cancer, and are being tested in other cancers, including ovarian cancer.

«This suggests we should pay attention to the potential involvement of these two genes in other cancer types.»

In cases where a tumor had not doubled the mutated KRAS gene copy, the researchers discovered duplications in other cancer genes.

The same mTOR pathway associated with overactive cell growth in TSC also is implicated in other cancers and neurological conditions, such as Alzheimer's disease, type 2 diabetes, Parkinson's disease, Huntington's disease and autism.

Since estrogen also plays an important role in other cancers, including breast cancer and prostate cancer, den Boon says this work has the potential to benefit other cancer - fighting efforts.

Dr Woll cautions: «It is important to emphasize that our studies only investigated cancer stem cells in MDS, and that the identity, number and function of stem cells in other cancers are likely to differ from that of MDS.»

«This heralds a new era in cancer treatment which is potentially revolutionary as it is likely similar techniques can be used in other cancer types.

Many questions remain, and Straussman and his group are now asking whether bacteria may be found in other cancer types and, if so, what effects they might have on the cancer and its sensitivity to other anti-cancer drugs including a novel family of immune - mediated anti-cancer drugs.

It will, therefore, be very interesting and potentially promising if similar effects are seen in other cancer types, such as lung cancer,» Balkwill noted.

A small number of these mutations have been found previously in other cancers, and drugs have been developed to target these mutations,» said lead author Raphael Bueno, MD, chief of the Division of Thoracic Surgery at BWH and co-director of the BWH Lung Center.

«This puts the existing U.S. bladder cancer approval in serious doubt, and will also, of course, raise market concerns about Tecentriq's efficacy in other cancer types,» Kepler Cheuvreux analyst David Evans wrote in a note to investors.

The researchers also found high mutation rates of YME1L1 in other cancers.

The Lund researchers have already started new studies in which a larger number of women will be monitored from breast cancer diagnosis and onwards, as well as testing ctDNA methods in other cancer types.

Researchers are currently testing pembrolizumab to determine if it has the same result in other cancers, as well as trying to combine pembrolizumab with other therapies.

Depression has been associated with increased likelihood of not getting the best treatment, as well as lower overall survival in other cancers, including breast and liver cancers.

«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»

PARP inhibitors are used primarily to treat tumors linked to defects in BRCA genes, but may show promise in other cancers when combined with other drugs.

It will not be easy, but Porter is hopeful that one day doctors specializing in other cancers will experience what he did when examining one of his leukemia patients not long after that phone call on the quad: He felt under the man's arm for his lymph nodes, which had been enlarged by the cancer for years.

HDAC inhibitors have been approved for use in blood cancers and are being tested for benefit in other cancers, such as breast, colorectal, gastric, liver, lung and prostate cancers that overexpress specific HDAC proteins.

«Considering that frequent amplification of MET accounts for resistance to therapies now in development and to poor prognosis, not only in ovarian cancer but in other cancers too, our findings pinpoint an important new signaling hub, involving the role of FER in MET activation.

The researchers are now looking whether NPTX2 may act in other cancers.

Using Epiviz and Bioconductor, the research team found consistent regions of DNA methylation changes in colon cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer types.

Velculescu, Anagnostou, Smith and their colleagues say they plan to determine how broadly this phenomenon occurs in other cancer types and potentially use it to develop new ways to improve current cancer immunotherapies.

Because these four microRNAs are also more abundant in other cancers, such as those of the lung and breast, this quartet can not be used to identify the type of cancer.

This process has been seen before in other cancers, but this is the first time it has been shown to be involved in all pancreatic tumours, and that each tumour evolved different genetic mechanisms to do this.

Assoc Prof Chng said, «Earlier studies on PRL - 3 have been conducted in other cancers, but only in recent years has attention been turned to the significance of PRL - 3 in blood cancer.

They tested the samples for longer telomeres that weren't the product of a protein called telomerase, which helps maintain telomere length in healthy cells and more commonly in other cancers.

«While there is understandable excitement around new therapies that enlist the immune system to fight cancer, we are still in a situation where greater than half of patients don't respond in melanoma and the response rate is even worse in other cancer types,» Hanks said.

For this purpose, the researchers used the computational tool IMPACT, developed in the Tan lab, to sort functional from missense mutations and to cross-reference candidate mutations with those previously reported in other cancer types.

We went on to test the role of NMD in other cancer types and the evidence of the role of NMD was compelling.

Barbolina and her colleagues hypothesized that biomolecules successfully targeted with drugs in other cancers might also be targets in metastatic ovarian cancer.

Preliminary evidence suggests that arsenic may have the same effect on telomerase in other cancers; human trials are ongoing.

Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.

«The next step of our work will see how this approach works in other cancer types, and we hope it could ultimately lead to testing this technique in trials to see if it can help patients.»

Some had mutations in other cancer genes, including the breast and ovarian cancer risk genes BRCA1 and BRCA2.

For example, HPV - inactive tumors were 17 times more likely to contain TP53 gene mutations — which are common in other cancer types — than HPV - active cervical cancers.

While such well - defined drug targets have been harder to identify in other cancers, Simon is optimistic that the rational approach to drug discovery will continue to show promise and invites collaborations with Hutch investigators studying potential anticancer drug targets.

Prostaglandins have an effect in other cancer types but they're particularly critical in colon cancer.

AbScan is freely available and can be used for understanding the immune response in other cancers.

If these transporters are identified, a similar approach can be used to establish the therapeutic potential of such transporters in other cancer subtypes as well.

As the biomarker literature becomes more expansive in other cancer types, Dr. Petty and his team aim to expand their work to other forms of cancer.