Sentences with phrase «in preclinical models»

The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia

5 - HT2C agonists have demonstrated efficacy in preclinical models of depression, obesity, and psychosis.

currently being evaluated for safety and efficacy in preclinical models with a Phase I trial expected to begin in 2018.

«Stem cell - based therapy for targeting skin - to - brain cancer: Stem cells loaded with oncolytic viruses show promising results in preclinical models for targeting skin cancer metastases in the brain.»

«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»

She has identified novel immune - modulating activities associated with targeted cancer drugs in preclinical models, and developed synergistic immunotherapy combinations.

M1: Passive transfer studies in preclinical model performed; Report on protection by passive therapy with human immune IgG

Over the last five years, promising results in preclinical models of SMA have led to a surge of clinical trials using small molecules, oligonucleotide - based therapies, and viral - mediated gene therapies.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

Immunoproteasome inhibition, in contrast, has proved effective in preclinical models of autoimmune diseases and was applied over weeks without obvious adverse side effects.

M2: Vaccination studies in preclinical model performed; Report on safety, immunogenicity, and preclinical efficacy of leading placental malaria vaccines product candidates

Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia Author: D. Martins - de-Souza et al..

With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells in preclinical models which is encouraging for the potential of this product as a monotherapy, combining immune - modulation and antibody dependent, cell - mediated cytotoxicity,» said Michel Detheux, Ph.D., Chief Executive Officer of iTeos.

With our anti-TIGIT antibody program, we saw anti-tumor efficacy and reactivation of T - cells in preclinical models which is encouraging for the potential of this product as a monotherapy

Complementing the company's in - house Crispr programme, the technology will identify and validate new targets in preclinical models across a range of disease areas.

The study concluded that DSM265 appeared to be safely tolerated in non-human tests and established optimal dosing levels and length of drug effectiveness in preclinical models to estimate dosing for humans, paving the way for clinical trials.

«This study for the first time shows increased expression of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in preclinical models of retina stress,» the authors note.

She has collaborated with interdisciplinary groups to investigate how nutritional supplements (phytochemicals and omega - 6 and omega - 3 fatty acids) affect menopause - associated metabolic disturbances and breast cancer in preclinical models (cell and mouse) and clinical settings.

While she began her research career studying addiction in preclinical models, her current NIH - funded research uses clinical neuroimaging to clarify how individual differences in brain...

Using a comprehensive profiling technique, the team was able to uncover a milieu of molecules known as specialized pro-resolving mediators (SPMs) in human breast milk and found that each of these molecules helped resolve inflammation and stimulate immune response in preclinical models.

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot - Marie - Tooth disease type 2A

«In 2015 our research team showed that blocking a different protein in the NOD2 pathway could halt inflammation, and was able to halt the progression of multiple sclerosis in a preclinical model.

«It performed so well in the preclinical model, we determined that to boost its effects further was essentially impossible,» said Orme, also a co-founder of CSU's Mycobacteria Research Laboratories.

A novel, synthetic, DNA - based strategy to provide protection against a broad array of influenza viruses has been developed in preclinical models by scientists at The Wistar Institute, MedImmune (the global biologics research and development arm of AstraZeneca) and Inovio Pharmaceuticals, Inc..

The study, «Optimizing Femoral - head Osteochondral Allograft Transplantation in a Preclinical Model,» recently was published in the Journal of Orthopaedic Translation.

Solving these problems in preclinical models is much more cost effective, but requires a multidisciplinary team that includes formulation experts, polymer scientists, and biologists who can interface with diverse scientists who don't normally talk to one another.

Delivering this inhibitor, Cp40, to the periodontal tissue just once a week reversed naturally occurring chronic periodontitis inflammation in a preclinical model.

However, when the researchers switched on KRAS in the preclinical models, an entirely different kind of tumor formed, called angiosarcoma.

Knowing that vitamin D is degraded during neuroinflammation and injury, Jenkins and her team investigated whether adding vitamin D to hypothermia and NAC would improve outcomes in a preclinical model, particularly in males.

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasis Lab.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

In a paper published in Advanced Functional Materials, the research team reports on the new material's key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.

«SPF30 sunscreens delay melanoma incidence in preclinical model: Current testing models gauge sunscreen's ability to prevent sunburns not prevent cancer.»

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

The team will continue testing the hydrogel in preclinical models to further validate it, and continue to advance toward human clinical trials.

Published this week in the journal Proceedings of the National Academy of Sciences, the scientists found that inhibiting activin A, activin B and myostatin resulted in skeletal muscle mass increase by as much as 150 per cent in preclinical models.

Currently, Doody is testing in preclinical models whether combining this agent with other, known rheumatoid arthritis treatments results in more efficacious therapies.

Study results showed that in preclinical models tumor - to - background ratios obtained from 11C - sarcosine PET were significantly elevated compared to 11C - choline.

Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma).

Researchers note that the genetic strategy employed in the preclinical model is not feasible in humans.

The initial studies are already under way in the preclinical model.

And there are a lot of treatments, or let's say potential treatments, that are working wonderfully in preclinical models that are ready to make the leap to human testing, and some of these have begun to make that transition to bridge from the laboratory to human - patient testing.

Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model.

Cigana C, Bernardini F, Facchini M, Alcalá - Franco B, Riva C, De Fino I, Rossi A, Ranucci S, Misson P, Chevalier E, Brodmann M, Schmitt M, Wach A, Dale GE, Obrecht D, Bragonzi A. Efficacy of the novel antibiotic POL7001 in preclinical models of Pseudomonas aeruginosa pneumonia.

These data suggest that a careful and systematic evaluation of targeted cancer therapies on cognitive functions in preclinical models may constitute a strategy of prevention by selection of treatments exhibiting minimum brain co-morbidities.

Monitoring Healing Progression and Characterizing the Mechanical Environment in Preclinical Models for Bone Tissue Engineering.

This has led to the demonstration that blocking the mobilisation of neutrophils can reduce metastasis in our preclinical models.