Sentences with phrase «islet amyloid»
The phrase "islet amyloid" refers to the presence of abnormal protein deposits in the clusters of cells in the pancreas called islets. These protein deposits can harm the normal function of the islet cells and may be associated with certain diseases, such as type 2 diabetes. Full definition
To corroborate the findings, the researchers also developed a novel mouse model that was deficient for autophagy specifically in beta cells with expression of the human form of islet amyloid polypeptide.
sciencedaily.com
People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.
Other factors that adversely affect β - cell numbers and function include islet amyloid deposition (24), glucose toxicity (25), pancreatitis (8), and certain dietary influences (26).
Fibrils immunoreactive for islet amyloid polypeptide are found in macrophages associated with amyloid, suggesting that deposits can be phagocytosed.
Complement activation by islet amyloid polypeptide (LAPP) and a-synuclein 112.
The cells also produce a hormone called islet amyloid polypeptide, or IAPP.
Islet amyloid, increased A-cells, reduced B - cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes
Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril formation
Human islet amyloid polypeptide expression in COS - 1 cells.
Preliminary results of histological examination of pancreatic tissue show a similar range of islet pathology in diabetic Burmese and diabetic domestic cats, which suggests that the mutation does not directly result in excessive deposition of islet amyloid polypeptide or another metabolic product causing destruction of β - cells (personal communication, R. Lederer, 2003).