Sentences with phrase «lung cells»

For example, smoking changes the epigenetic makeup of lung cells, eventually leading to cancer.

Two groups decided to explore this idea more thoroughly in lung cells.

Women are twice as likely as men to have asthma, and this gender difference may be caused by the effects of sex hormones on lung cells.

Unlike with the typical methods for drug delivery used in chemotherapy, the system did not attack healthy lung cells.

They were then able to multiply the harvested lung cells in the lab to yield enough cells sufficient for human therapy.

Diseases affecting the lung, including emphysema, cystic fibrosis, acute respiratory distress syndrome and pulmonary fibrosis, cause considerable morbidity and mortality in the U.S.. However, there are not many treatment options available for those diseases, in part due to the limited availability of human lung cells for research.

Previously, stem cells have been made to differentiate into lung cells using a cocktail of different growth factors, but Haute says using physical forces might be simpler.

The team started with decellularized adult rat lungs, which retain the organs» branching airways and blood vessel network, and added a mixture of lung cells from newborn rats.

One team has grown lung cells that performed their gas - exchange functions when transplanted into living rats.

They found that exposing lung cells with the ΔF508 mutation to VX - 770 long - term — mimicking what happens in patients who take the drug for extended periods — often made the CFTR protein function poorly when compared with short - term exposure.

The influenza virus turns infected lung cells into factories that churn out thousands of copies of the virus to spread the infection.

An improved differentiation strategy allows the production of iPSC - derived lung cells with improved regenerative and reparative potential.

What is most impressive about the chip, says Michael Shuler, a biomedical engineer at Cornell University in Ithaca, New York, is that it mimicked not just the physiology of the lung, but also the mechanical forces that act on lung cells as the chest expands and contracts with each breath.

«With our collaborators, we were able to identify factors that we can use to more optimally generate patient - derived lung cells in vitro,» said Katie McCauley, Ph.D., a post-doctoral fellow in the CReM and the study's first author.

Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the study, suspected that the interplay of epigenetic and genetic changes may occur when normal lung cells develop into cancer, but, Baylin says, the timing of such changes was unknown.

Emissions from e-cigarette aerosols and flavorings damage lung cells by creating harmful free radicals and inflammation in lung tissue, according to the UR study published in the journal PLOS ONE.

In fact, studies show that dust mites and the allergic reactions they provoke are a root cause of asthma in children and can actually cause lung cell death.

Panoskaltsis - Mortari, an author on one of the other recent lung - engineering studies using a similar matrix, and her group presented data at a conference last month showing that iPS cells can differentiate into a key type of lung cell when grown on decellularized matrices.

Am J Physiol Lung Cell Mol Physiol.

The modified toxin could treat asthma, in which lung cells secrete too much mucus, and cancers in which cells overproduce cytokines.

It's the same mechanism that punctures lung cells in asbestosis.»

MIMICKING the environment experienced by cells in the windpipe is enough to transform stem cells into a range of different lung cells.

«E-cigarette vapors, flavorings, trigger lung cell stress.»

Certain flavorings in e-cigarettes can harm lung cells, researchers report May 17 at the American Thoracic Society International Conference in Denver.

Liver and lung cells remained untouched.

The result: tiny green spheres about half a millimeter across, «a population of pure, early lung cells,» says Hawkins.

Now, he could easily spot and purify the glowing green lung cells.

McCauley, looking at the earliest stages of the disease, wanted to take Hawkins» purified lung cells to the next step and figure out how they became airway cells.

By turning the pathway off, she guided the immature lung cells into becoming airway cells.

Mice who couldn't produce CHI3L1 / BRP -39, had acute lung cell damage, somewhat like AE patients who have a relative deficiency of CHI3L1.

«Researchers identify changes in lung cells following infections: Discovery may lead to new strategies for treating pneumonia.»

They are mature lung cells that awaken in response to injury.

«We want to know if we can, and how, to make new lung cells as work - arounds for diseased alveoli cells,» says Jain.

They show that these lncRNAs are often located near transcription factors in the genome of lung cell lineages.

Researchers scanned the genes of lung cells scraped from 24 smokers, abstainers and former pack - a-dayers who puffed for 30 years or more.

They focused on lung cells called Group 2 innate lymphoid cells, or ILC2 cells.

The assay uses a robotized system that gives candidate drugs to cultured lung cells that have been infected with M. tuberculosis.

For more than 60 years, Robert Martensen's lung cells replicated without a hitch, regulated by specialized enzymes called kinases.

They have enough newborn mouse lung cells to start the protocol, they reported, and will make the pipettes the new protocol describes tomorrow.

For the study, conducted as part of the doctoral thesis of Mahesh Raundhal, a graduate student in the laboratory of Prabir Ray, Ph.D., Pitt professor of medicine and co-senior author, the research team examined lung cell samples obtained from patients also participating in the Severe Asthma Research Program (SARP), a National Heart, Lung, and Blood Institute of the National Institutes of Health - sponsored program to improve the understanding of severe asthma.

But in earlier work Drs. Summer and Romero have shown that when lung tissue is injured — by things like viral infection, particulate inhalation, or other insults — lung cells eventually stop producing lipids in order to conserve energy for other cellular repairs.

Senescence impairs lung function in two ways: It prevents lung cells from dividing when they need to be replaced.

The research team included Scott H. Randell, Ph.D., a leading expert in the culture of primary lung cells, from the Cystic Fibrosis / Pulmonary Research and Treatment Center at the University of North Carolina at Chapel Hill.

While learning how to culture rhinovirus C, Palmenberg's research team discovered the virus only infects certain lung cells that express a particular genetic form of a cell - surface molecule called cadherin - related protein 3 (CDHR3).

Thomson's group created human iPS cells using fetal lung cells and foreskin cells with two of the same factors as Yamanaka, along with two different factors.

Binding of JSRV sheep lung cells might interfere with the receptor's normal role in regulating cell proliferation, causing unregulated growth.