Diseases affecting the lung, including emphysema, cystic fibrosis, acute respiratory distress syndrome and pulmonary fibrosis, cause considerable morbidity and mortality in the U.S.. However, there are not many treatment options available for those diseases, in part due to the limited availability
of human lung cells for research.
Although the drug did not block the virus from
infecting human lung cells, investigators demonstrated that BEZ235 reduced viral replication by limiting the ability of the infected cells to use glucose and glutamine to fuel production of more flu viruses.
In the second study in Science, researchers from Harvard University in Boston, Massachusetts, created a chip 1 to 2 centimeters long in which a 1 millimeter - wide channel, coated with
human lung cells on the inside and overlaid with human blood capillaries on the outside, mimicked the air sacs, or alveoli, of the lungs.
First, the destabilizing effects of VX - 770 on the corrected CFTR protein might be less robust in the human body than were the effects seen in lab tests
using human lung cells.
A team led by cell biologist Martina Gentzsch at the University of North Carolina, Chapel Hill, looked at a type
of human lung cell that's often used in CF studies, with the ΔF508 mutation.
We've also found that in a petri dish, the anti-quorum-sensing molecule prevents Pseudomonas from
killing human lung cells and from making a biofilm that would enable it to mount an attack.
To answer this question, Imai and her team screened for PUFA - derived lipids in influenza - virus -
infected human lung cells.
A 2005 study in Environmental Science and Technology showed that zinc oxide particles were toxic to
human lung cells.
Researchers observed in the laboratory that
human lung cells exposed to e-cigarette aerosols released various inflammation biomarkers.
When the team turned to
human lung cells, they found that A20 was also less active in adults with asthma.
In work published in The EMBO Journal, the researchers reveal that the delivery of mitochondria to
human lung cells can rejuvenate damaged cells.
Lambrecht and his team then turned to
human lung cells and found that A20 was less active in adults who had asthma.
The researchers demonstrated that LecA and Gb3 are also important for bacterial invasion in
human lung cells: When the pair of molecules was missing, the number of germs that infiltrated the cells was reduced by up to 70 percent.
Römer and Eierhoff found evidence of the new mechanism in synthetic membranes as well as in cultures of
human lung cells.
Recently, our laboratory discovered that fungi secrete sugars that can act as a glue in order to help fungi attach to
human lung cells and hide from the immune system during lung infections.
STUDY TWO — next we have this study in which scientists analysed the effect of fluoride on
human lung cells.