Sentences with word «mammalian»

Working with proteins called zinc finger nucleases and TALENs, Zhang attempted to edit the genomes of mammalian cells with a view to engineering them.

The use of CRISPR / Cas9 for gene editing has expanded since its adaptation for use in mammalian cells in 2012 - 2013.

The system can change single RNA nucleotides in mammalian cells in a programmable and precise fashion.

One of our core disciplines is the development and use of genetic technologies which we primarily apply to the mouse genome, although we also embrace studies in other mammalian genomes.

Leucine - enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

qBrain is built on an automated technology platform that will be used to perform similar analyses of other mammalian brains, from prairie voles to marmoset monkeys and humans.

Thelazia callipaeda is a parasitic worm capable of infecting a range of mammalian host species including dogs, cats and human beings.

Designer Receptors Exclusively Activated by Designer Drugs, or DREADD, technology was first developed by one of the co-authors (B.L. Roth) for mammalian systems and overcomes many of the limitations of switch - based approaches.

A lot of research done on mammalian brains has been done on rats (sorry rats!)

One huge step forward came in 1985, when researchers began shuttling genes into mammalian cells by first transferring them to a virus.

Because so little is known about Gondwanan mammals, Krause is wary of dismissing Rich's interpretation «just because we don't expect, based on current knowledge of early mammalian evolution on Gondwana, to see a placental mammal in the Early Cretaceous of Australia.»

The laboratory mouse, small and easy to breed, has long been biologists» favorite model organism for studying mammalian development.

Each of the 2,000 varieties is made from mammalian milk in a process consisting of some nine steps.

«Once we start to correlate particular patterns of activity to behaviors or mental states,» says Rafael Yuste, a neuroscientist at Columbia University who studies mammalian brain circuitry, «we will reinvent neuroscience as a field.»

Preventing the disease by developing a vaccine seems difficult because of the ability of the trypanosome to thwart mammalian immune systems.

Drawing inspiration from how mammalian brains process sight, researchers have found a way to mimic the functions of biological neural networks on a next - gen «memristor» chip.

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

It is possible that many other mammalian predators make long - distance expeditions to localised pulses of prey availability; however, there is little documented evidence for this.

For this, we study the developing, adult and regenerating liver as mammalian organ model system.

Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single - cell mammalian embryo.

Two different mammalian family trees portraying alternative timelines for the evolution of mammals were used in the analysis.

John Marioni from EMBL - EBI, Sanger Institute & CRUK Cambridge Institute, presented his research on early mammalian development using single - cell transcriptomics.

«What is clear is that the multi-layered mammalian cortex is not required for complex cognition,» concludes Güntürkün.

Most surprising was the observation that the NSM accurately predicts the maximum mammalian body size observed in the fossil record,» explains Yeakel.

Because yeast prions act much like mammalian prions and are easier to study, scientists hope they will offer clues about how these mis - folding chain reactions get started and how they might be stopped.

To our knowledge, this is the first demonstration of temporal functional metagenomics using shotgun libraries applied to the in vivo mammalian gut environment.

Addressing Quality in Cell - Line Development — Direct Analysis of Bioreactor Harvest for Clone Selection and Process Optimization Therapeutic monoclonal antibodies mostly are manufactured using mammalian cells cultured in a bioreactor for two to three weeks.

F. Lescroart, S. Chabab, X. Lin, S. Rulands, C. Paulissen, A. Rodolosse, H. Auer, Y. Achouri, C. Dubois, A. Bondue, B. D. Simons, C. Blanpain Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development Nature Cell Biology 16, 829 — 840 (2014)

The feeding habits made Haramiyavia the earliest known herbivore among mammalian ancestors and placed them apart from other early proto - mammal groups, which had teeth adapted to insect or worm - based diets.

Their findings point to a conserved sequence among mammalian genomes that was only present in the J element and not in any other class II elements.

«In 2015, we had reported the synthesis of a molecule with demonstrated period - shortening activities on mammalian circadian clocks discovered through a collaboration between ITbM's chronobiologists, synthetic chemists and theoretical scientists,» says Yoshimura.

Lukas and Huchard looked at mammalian groups with a variety of social systems — from mice to mongoose and from bats to bears.

The reptilian part of our brain can activate a similar response, which is needed when the higher order mammalian response is not effective.

Scientists have known for a long time that influenza A — the culprit behind all major pandemics — uses ducks and other aquatic birds as its refuge, but also infects many mammalian species.

I marveled at a chart that showed a diagram of the tree of life, where relationships between different mammalian species were figured out solely by comparison of their DNA sequences, providing powerful support for Darwin's idea of descent from a common ancestor with natural selection operating on randomly occurring variations.

That's despite the many contributions of the Drosophila model to understanding mammalian biology — like the chromosomal basis of inheritance, genetic linkage, body plan development, the molecular basis of innate immunity, circadian rhythms, and more.

But inserting genes into mammalian neurons inside an intact brain required a larger number of more virulent viruses.

When you join JAX, you become part of a widely respected organization with a distinguished history in mammalian genetics research and a promising future in genomic medicine.

Another mystery, said Bjorkman, is that the FcRY receptor does not resemble FcRn structurally, but more closely resembles an entirely different, poorly understood mammalian protein called the phospholipase A2 receptor, which is found in muscle.

As it turns out, for our seagoing mammalian counterparts at least, life among the waves isn't harsh enough to keep from having a good time.