Sentences with phrase «marrow cells»
Marrow cells refer to the cells found inside our bones, specifically in the soft tissue called bone marrow. These cells are responsible for making different types of blood cells, such as red blood cells, white blood cells, and platelets, which are essential for our body's functioning. Full definition
For their discoveries of molecules that regulate the growth and differentiation of bone marrow cells in health and disease.
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They are then replaced with bone marrow cells from a healthy donor.
Some meta - analyses have concluded that bone marrow cells provide modest benefits in terms of heart function; critics have argued it doesn't actually do much good.
More than 40 clinical trials are underway using other kinds of stem cells, mainly bone marrow cells from the patients themselves.
They withdrew bone marrow cells from the two babies when they were 8 and 11 months old.
Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration.
For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.
The doctors» plan was to kill off Brown's cancer - producing bone marrow cells with intensive chemotherapy and replace them with stem cells from the bone marrow of a healthy donor.
Earlier this year, Lerner, Xie and their colleagues reported using the new method to find an antibody that can perform the remarkable trick of turning bone marrow cells into young brain cells, via a previously unknown signaling mechanism.
Myelofibrosis is a slow evolving condition hallmarked by increased myeloid cells and in the case of primary myelofibrosis, with an excessive number of large bone marrow cells called megakaryocytes.
For that to be done successfully, a bone marrow donor match has to be found, and then chemotherapy given, before a person with the disease is ready to have donor bone marrow cells transplanted.
Bone marrow cells cultured with conditioned medium derived from ABL1 / ABL2 knockdown 1833 and SKBR3 breast cancer cells had decreased numbers of TRAP + cells compared to the control groups (Fig. 5, B and C, and fig.
They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.
Lymph nodes and bone marrow cells by default are the fastest in dividing and hence the virus depletes healthy lymphocytes found in these two types of tissues.
(The recipient mice also received an injection of their own bone marrow cells collected prior to radiation to make it possible to quantify the relative abilities of the donated stem cells to engraft successfully.)
This work, published in «Blood», was carried out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport of the telomerase gene to the bone marrow cells using gene therapy, a completely new strategy in the treatment of aplastic anaemia
They found that cyclophosphamide kills all of the donor's transplanted bone marrow cells except for stem cells containing high levels of an enzyme called aldehyde dehydrogenase (ALDH).
Nayernia says that researchers have produced the same early - stage sperm cells in mice from bone marrow cells taken from female mice.
In acute myeloid leukemia, undifferentiated bone marrow cells grow uncontrollably in the blood and bone marrow, crowding out and destroying healthy cells.
The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.
By receiving transplants of bone marrow cells along with the new kidney, four of five transplant patients with end - stage renal disease were able to stop taking immunosuppressive drugs within about one year after surgery.
Bone marrow cells do not normally grow in the lab, but the team reported that by carefully controlling the amount of oxygen the cells received along with other growth conditions, they could keep the cells alive for at least a year.
Blood vessels shuttle important nutrients to healthy cells and remove waste; nerves provide connection to the brain; and, bone marrow cells form new blood and immune cells,» said Marolt.
(B) TRAP staining of bone marrow cells treated with conditioned medium (CM) from 1833 breast cancer cells.
Thousands of heart attack patients have been treated with bone marrow cells so far, and a very large study of this approach (BAMI) is proceeding in Europe.
Bone marrow cells induce stable mixed chimerism under appropriate conditioning of the host, mediating the induction of transplantation tolerance.
Jerrold Olefsky and colleagues at the University of California, San Diego, killed the bone marrow cells in mice that make immune cells called macrophages.
In a third of MDS cases, over time, very immature bone marrow cells called blasts may increase in number and fill the bone marrow, displacing the normal red and white blood cells and platelets that are produced there.
An assessment of the bone marrow is made by collecting bone marrow cells for examination, or looking for circulating mast cells with white blood cells.
Il3 alone does not support granulocyte / macrophage colony formation in bone marrow cells from A / J mice but does in bone marrow from C57BL / 6 controls; costimulation with both Il3 and SCF increases the number of colonies formed compared to SCF alone
And then we infect bone marrow cells with the vector — those cells ultimately give rise to the immune system.
In the test tube, the bone marrow cells produced about 20 to 30 per cent of a healthy person's level of normal haemoglobin.
«There was initially a lot of excitement with the heart, that you could squirt, for example, bone - marrow cells, a cell type we thought we understood really well.
Unexpectedly, mice injected with the radioactive phosphorus produced fewer white blood cells, and he theorized that the element suppressed production of bone marrow cells.
Binding of S100A8 / S100A9 to RAGE stimulated bone marrow cells to produce monocytes.
This monocyte production created a vicious cycle whereby high blood sugar levels boosted neutrophil numbers, leading to excess secretion of S100A8 / S100A9, which in turn stimulated bone marrow cells to produce more monocytes.
The investigators also discovered that neutrophils secrete a molecule called S100A8 / S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marrow cells.
Plaque formation accelerated in the models transplanted with Tet2 - deficient bone marrow cells, likely through increasing macrophage - driven inflammation in the artery wall.
We have identified a signalling pathway that, once activated, allows the neurons to be reprogrammed through their fusion with bone marrow cells,» explains Pia Cosma, head of the Reprogramming and Regeneration group at the Centre for Genomic Regulation and ICREA research professor.
Dr Ng said the hormone thrombopoietin was responsible for signalling bone marrow cells to produce platelets but, until now, researchers did not know precisely which cells responded to its signals.
The discovery, made by scientists at the Walter and Eliza Hall Institute, identified how bone marrow cells could become overstimulated and produce too many platelets.
Patients were considered free of MRD if less than one cancer cell could be detected in 1,000 normal bone marrow cells.
To gauge the impact of hemozoin and other parasite wastes, the team cultured bone marrow cells in a cocktail of these substances.
Researchers have long known that a follow - up infusion of bone marrow cells from the same donor eases the transition, but they haven't known why.