Sentences with phrase «bone marrow cells»

For their discoveries of molecules that regulate the growth and differentiation of bone marrow cells in health and disease.

They are then replaced with bone marrow cells from a healthy donor.

They rapidly become space - occupying and start to crowd out normal bone marrow cells that otherwise would develop into healthy, mature red and white blood cells.

More than 40 clinical trials are underway using other kinds of stem cells, mainly bone marrow cells from the patients themselves.

The leading theory for this observation is that the foreign bone marrow cells can more easily recognize and attack cancer cells in their new host's body.

They withdrew bone marrow cells from the two babies when they were 8 and 11 months old.

Some meta - analyses have concluded that bone marrow cells provide modest benefits in terms of heart function; critics have argued it doesn't actually do much good.

Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration.

The doctors» plan was to kill off Brown's cancer - producing bone marrow cells with intensive chemotherapy and replace them with stem cells from the bone marrow of a healthy donor.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.

Earlier this year, Lerner, Xie and their colleagues reported using the new method to find an antibody that can perform the remarkable trick of turning bone marrow cells into young brain cells, via a previously unknown signaling mechanism.

The lack of a difference between the syngeneic 129SvJ and allogenic MRL mice suggested that the decline in the donor cells was not due to rejection, but rather to out - competition of the HPCs by autologous bone marrow cells.

Thousands of heart attack patients have been treated with bone marrow cells so far, and a very large study of this approach (BAMI) is proceeding in Europe.

(The recipient mice also received an injection of their own bone marrow cells collected prior to radiation to make it possible to quantify the relative abilities of the donated stem cells to engraft successfully.)

And then we infect bone marrow cells with the vector — those cells ultimately give rise to the immune system.

This monocyte production created a vicious cycle whereby high blood sugar levels boosted neutrophil numbers, leading to excess secretion of S100A8 / S100A9, which in turn stimulated bone marrow cells to produce more monocytes.

To gauge the impact of hemozoin and other parasite wastes, the team cultured bone marrow cells in a cocktail of these substances.

Myelofibrosis is a slow evolving condition hallmarked by increased myeloid cells and in the case of primary myelofibrosis, with an excessive number of large bone marrow cells called megakaryocytes.

For that to be done successfully, a bone marrow donor match has to be found, and then chemotherapy given, before a person with the disease is ready to have donor bone marrow cells transplanted.

The investigators also discovered that neutrophils secrete a molecule called S100A8 / S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marrow cells.

(B) TRAP staining of bone marrow cells treated with conditioned medium (CM) from 1833 breast cancer cells.

They found that cyclophosphamide kills all of the donor's transplanted bone marrow cells except for stem cells containing high levels of an enzyme called aldehyde dehydrogenase (ALDH).

Plaque formation accelerated in the models transplanted with Tet2 - deficient bone marrow cells, likely through increasing macrophage - driven inflammation in the artery wall.

Dr Ng said the hormone thrombopoietin was responsible for signalling bone marrow cells to produce platelets but, until now, researchers did not know precisely which cells responded to its signals.

The discovery, made by scientists at the Walter and Eliza Hall Institute, identified how bone marrow cells could become overstimulated and produce too many platelets.

Nayernia says that researchers have produced the same early - stage sperm cells in mice from bone marrow cells taken from female mice.

«Those infused bone marrow cells must play an active role.»

Within a few weeks, the mesenchymal stem cells have been modified to form cartilage tissue, and within months, the site becomes calcified, forming natural bone containing bone marrow cells.

In acute myeloid leukemia, undifferentiated bone marrow cells grow uncontrollably in the blood and bone marrow, crowding out and destroying healthy cells.

The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.

By receiving transplants of bone marrow cells along with the new kidney, four of five transplant patients with end - stage renal disease were able to stop taking immunosuppressive drugs within about one year after surgery.

Bone marrow cells do not normally grow in the lab, but the team reported that by carefully controlling the amount of oxygen the cells received along with other growth conditions, they could keep the cells alive for at least a year.

Blood vessels shuttle important nutrients to healthy cells and remove waste; nerves provide connection to the brain; and, bone marrow cells form new blood and immune cells,» said Marolt.

One year after being treated with genetically modified bone marrow cells, the babies have normal immune systems and no longer need to live in a sterile «bubble.»

Ovine cortical osteoblasts outperform bone marrow cells in an ectopic bone assay.

In a third of MDS cases, over time, very immature bone marrow cells called blasts may increase in number and fill the bone marrow, displacing the normal red and white blood cells and platelets that are produced there.

Surgeons at Houston's Memorial Hermann Hospital believe they might have a novel way to prevent that ongoing harm: by drawing bone marrow cells, including stem cells, from patients and infusing them back into their bodies.

In the recent study, the researchers used CRISPR snipped out the sickle cell mutation from donated human bone marrow cells, and replaced it with non-mutated DNA.

After enrollment, patients had cells extracted from their bone marrow and received an intracoronary injection of sorted bone marrow cells or a placebo.

Meanwhile, a clinical trial similar to PreSERVE - AMI involving treatment with mesenchymal bone marrow cells is currently underway at Emory, sponsored by CardioCell / Stemedica.

The PreSERVE - AMI study looked at naked bone marrow cells, sorted to enrich for CD34 + cells with progenitor potential.

To create pigs using pluripotent stem cells, the UGA team injected new genes into pig bone marrow cells to reprogram the cells into functioning like embryonic stem cells.

In this study, extracted bone marrow cells were shipped to NeoStem's facility and a marker for endothelial progenitor cells called CD34 was used to select progenitor cells before cells were returned for intracoronary injection.

Several previous studies of cell therapy for heart attack have used unsorted bone marrow cells.

However, this study demonstrates that genetic correction of CD34 + bone marrow cells can alter brain inflammation in ALD.