Sentences with phrase «marrow failure»

All of our materials are written in plain language and reviewed by highly respected and recognized medical doctors who are experts in bone marrow failure diseases.

There are many therapies and approaches doctors use to treat bone marrow failure disease patients.

Bone marrow failure patients are at risk for developing iron overload if they have had more than 20 units of packed red blood cells.

People exposed to large doses of radiation face challenges due to bone marrow failure induced by such exposures.

Bone marrow failure affects about seven in 100,000 people annually.

Unfortunately she was recently treated for anemia due to bone marrow failure because of over vaccinations.

Bone marrow failure disease patients are at risk for developing iron overload if they have had more than 20 units of packed red blood cells.

If you have a bone marrow failure disease, you may want to consider taking part in a clinical trial, also called a research study.

Lethal neonatal bone marrow failure syndrome with multiple congenital abnormalities, including limb defects, due to a constitutional deletion of 3 ′ MECOM

The Bone Marrow Failure Program at Dana - Farber / Boston Children's In addition to providing information and access to local and national research initiatives, our clinic offers multidisciplinary care (physician specialists, dentists, nurse practitioners, social workers) and consultative services for patients with Diamond - Blackfan anemia.

«Our goal is to find out what causes this bone marrow failure during serious infections, and find ways to prevent it,» said Nadia Carlesso, M.D., Ph.D., professor of pediatrics and of medical and molecular genetics at the IU School of Medicine.

«Source of stem cells used for bone marrow failure treatment varies worldwide.»

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

Eighty percent of patients with DC develop bone marrow failure before reaching age 30.

This basic fact makes it difficult for researchers to discern the underlying mechanism of the disease: «It's very difficult to figure out what's wrong, because the bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Center.

Using specimens collected annually in patients seen at Dr. Young's bone marrow failure clinic at the NIH Clinical Center, the investigators show that patients can support good blood cell production for many years from only a few stem cell clones, which can contain many unfavorable mutations.

Patients who suffer from Fanconi anemia display bone marrow failure already during childhood and have a risk of developing cancer that is about 1,000 times higher compared to healthy individuals.

Ayami Yoshimi, M.D., Ph.D., of the University of Freiburg, Germany, and colleagues examined the use of peripheral blood stem cells and bone marrow as stem cell sources for hematopoietic stem cell transplantation in patients with bone marrow failure worldwide and factors associated with the use of each stem cell source.

Over the years, Dr. Nimer has conducted extensive clinical and basic science research into the treatment and genetic basis of adult leukemia and bone marrow failure states, defining the regulatory mechanisms that control the production of blood cells and exploring ways to improve the treatment of blood based cancers.

These summaries of abstracts presented at major hematology / oncology scientific meetings contain some of the most up - to - date information about new research into the biology and treatment ofbone marrow failure disease.

Cavalancia met with Amy DeZern, M.D., and Robert Brodsky, M.D., of Hopkins» Center for Bone Marrow Failure Disorders, who took another bone marrow biopsy, and two days later flew out to Seattle to meet the specialists there.

He then completed his Internal Medicine residency and Hematology / Oncology fellowship training at Cleveland Clinic, in addition to a research fellowship in bone marrow failure syndromes at the same institution.

Continue reading to learn more about congenital amegakaryocytic thrombocytopenia or visit the Bone Marrow Failure Program homepage to learn about our expertise and treatment options.

Darbepoetin alfa can help improve red blood cell counts in bone marrow failure patients whose natural erythropoietin levels are low.

ATG may be used to treat other bone marrow failure diseases in some cases.

The data suggest that this immunosuppression - only approach could benefit patients with DC — and, perhaps, other bone marrow failure syndromes — who are at high risk of poor transplant outcomes because they can not tolerate the toxicity of conventional or even reduced - intensity conditioning.

In DC and other bone marrow failure syndromes, however, the disease itself already weakens or destroys the patient's bone marrow, raising the question of whether a less toxic approach could effectively condition patients for transplant.

While an HSCT can cure the resulting bone marrow failure, outcomes are often poor, likely because of the toxicity associated with conventional conditioning.

«Bone marrow failure syndromes are problems of blood and immune cell production,» he added.

In further studies, the researchers tested the capacity of ANG to prevent and mitigate radiation - induced bone marrow failure, and in pre-clinical models, they found that survival following radiation exposure was increased after treatment with recombinant ANG protein.

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin (ANG) that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation - induced bone marrow failure.

Even though bone marrow failure is a very rare disease, what it showed was that if you have a defective gene for this essential telomerase component, you will never live to be old [sufferers die in their twenties and thirties].

In terms of human health, there was a study in 2001 about patients who had progressive bone marrow failure.

Fanconi anemia afflicts several thousand people worldwide, causing severe bone marrow failure, birth defects, and a form of leukemia.

«If we can show that ItpkB also keeps human HSCs healthy, this could open avenues to target ItpkB to improve HSC function in bone marrow failure syndromes and immunodeficiencies or to increase the success rates of HSC transplantation therapies for leukemias and lymphomas.»

With this new understanding of the enzyme, called Inositol trisphosphate 3 - kinase B (ItpkB), scientists are closer to improving therapies for diseases such as bone marrow failure syndrome, anemia, leukemia, lymphoma and immunodeficiencies.

When a person's bone marrow is unable to keep up with the need for healthy blood cells, bone marrow failure is triggered.

Mutations in many of the genes that regulate DNA interstrand cross-link repair cause Fanconi anemia, a rare disorder that can lead to infertility, bone marrow failure, and predisposition to cancer.

For the current study, researchers used next - generation DNA sequencing, a way of rapidly analyzing genes, to examine the genomes of blood samples from more than 400 patients with aplastic anemia, enrolled from centers specializing in the treatment of bone marrow failure.

«We found that TRAF6 overexpression in mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.

The authors write that PBSCs are still used, despite disadvantages in patients with bone marrow failure, most likely because centers obtain PBSCs routinely for other indications and cell separators are available at any transplant center.

Among 114,217 HSCTs reported by 1,482 transplant teams, 3,282 allogeneic (receipt of stem cells from another individual) HSCTs were performed for bone marrow failure.

Bone marrow is currently recommended for HSCT in patients with bone marrow failure.

Unrelated donor registries should provide information on the necessity of bone marrow donation for patients with bone marrow failure.»

A disease of bone marrow failure, the condition can cause skeletal deformities and increases cancer and anemia susceptibility.

Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for many patients with bone marrow failure.

The pathology also is characterized by structural abnormality of the bone marrow matrix, which at end - stage manifests in excessive deposition of reticulin fibers and cross-linked collagen in the bone marrow, suppression of normal blood cell development and bone marrow failure.