Sentences with phrase «mechanical cues»

They found that as women age, the cells responsible for maintaining healthy breast tissue stop responding to their immediate surroundings, including mechanical cues that should prompt them to suppress nearby tumors.

«Knowing how cells respond to mechanical cues in the living embryo and how they physically sculpt tissues and organs in the 3D space will transform the way we think about developmental processes,» said Otger Campàs, a professor in the Department of Mechanical Engineering at UCSB and senior author on the paper that reports this novel technique in Nature Methods.

Whether building organs or maintaining healthy adult tissues, cells use biochemical and mechanical cues from their environment to make important decisions, such as becoming a neuron, a skin cell or a heart cell.

Now, a team of researchers led by the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has found that Escherichia coli (E. coli) may use mechanical cues to keep their shape.

«Our method provides new design criteria for materials used in regenerative medicine, and the work also provides more support to the general concept that stem cell fate can be regulated by mechanical cues,» adds Mooney.

«It's been well established in the plant field that mechanical cues can bias plant growth.

Scientists have focused for decades on the role of biochemical cues in embryonic development, Campàs said, because no techniques existed to measure the mechanical cues that cells are exposed to during the formation of tissues and organs.

As a consequence, it was not possible to know how cells respond to the mechanical cues they perceive as they build tissues and organs.

Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: «We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors.

«The mechanical properties of substrates play an important role in the cell behavior because the mechanical cues that cells sense in the actual (heart) environment is unique,» Abadi says.

How do they use molecular and mechanical cues to know where they are, or which direction they should move?

Leveraging the phylogenetic position of Cnidaria and the accessibility of Nematostella tentacle tubes to optical observation and experimental manipulation (see Video 2), we will define the biochemical and mechanical cues that drive the morphogenesis of epithelial tubes in a broad evolutionary context.

In a second step, the female integrates sensory information from chemostimulatory and chemodeterrent cues, together with other chemical (e.g., pH, alkalinity) and mechanical cues (7), to resolve whether the water container represents a suitable oviposition site.

Synthetic systems from the Santore lab recreate biological mechanisms that start at the surface and become large scale — examples will include materials that selectively scavenge, capture, kill or release targets in response to chemical and mechanical cues; control particle movement on surfaces; and assemble into molecularly thin force - responsive reconfigurable circuitry.