Sentences with word «metastatic»

«For patients with metastatic cancer of the brain, the importance of surviving for a longer period of time can not be overstated,» Litofsky said.

In the brief time that drugs known as CDK4 / 6 inhibitors have been approved for the treatment of metastatic breast cancer, doctors have made a startling observation: in certain patients, the drugs — designed to halt cancer cell division — do not just stop tumors from growing but can cause them to shrink, in some cases markedly.

Rashid OM, Nagahashi M, Ramachandran S, Yamada A, Graham L, Milstien S, Spiegel S, Bear HD, Takabe K. Resection of the Primary Tumor Improves Survival in Metastatic Breast Cancer by Reduction of Overall Tumor Burden.

Among patients with metastatic melanomas with the worst prognosis (stage M1c), the average progression - free survival times were 8.5 months for the combination treatment, 5.4 months for nivolumab alone and 2.8 months for ipilimumab alone.

«New combination of immunotherapy drugs is safe, shrinks tumors in metastatic melanoma patients.»

He has since had to undergo a left leg amputation above the knee and also surgery for metastatic disease in his left shoulder muscle.

For the study, Denmeade and his colleagues enrolled 16 men who had been receiving testosterone - lowering treatment for metastatic prostate cancer at Johns Hopkins.

Medical oncologist Samuel Denmeade, M.D., who led the small study of 16 patients with metastatic prostate cancer, warns that the timing of testosterone treatment used in his research is critical and difficult to determine, and says men should not try to self - medicate their cancers with testosterone supplements available over the counter.

Interestingly, Bos and colleagues recently reported that EGFR and its ligand were highly expressed in brain metastatic cells and knockdown of EGFR ligands significantly attenuated cell motility and invasion in vitro and in vivo.

Repurposing a drug compound to prevent the spread of cancer could be a game - changer in the prevention and treatment of metastatic brain disease,» said Stephen T. Wong, Ph.D., P.E., chair of the systems medicine and bioengineering at Houston Methodist Research Institute and one of the corresponding authors.

Using multiplex arrays and a variety of experimental approaches, they analyzed the specimens for gene targets that positively or negatively correlated with metastatic potential of the tumors.

«Women with this type of breast cancer also frequently develop metastatic lesions that originate from drug - resistant cells.

Yang et al. report on one such strategy: Taking the knowledge that an increase in type I interferons (IFNs) correlates positively with clinical outcome in several cancers and that type I IFNs can enhance antitumor immunity in some models, the authors tethered IFN - β to a monoclonal antibody targeting the epithelial growth factor receptor (EGFR), which is approved for use in treating metastatic colorectal cancer and head and neck cancer.

Toward this goal, we isolated CSCs population (CD24 − / CD44 + / ESA +) from metastatic breast cells and conducted miRNA profile analysis.

1) The key finding that periostin acts as a fundamental stromal factor for metastatic progression has been meanwhile experimentally validated in several independent labs by using other models.

TMA cores are useful surrogates for core biopsies, which are typically obtained to access tissue from metastatic sites in patients with unresectable disease.

Among patients with deadly cancers, more than 90 percent die because of metastatic spread of their disease.

However, for the 20 - 30 percent of patients who develop metastatic disease, the discovery of new treatment options is critical.

«People don't talk about «curing» patients with metastatic lung cancer.

In a second group of experiments using human tissue from patients with pancreatic ductal adenocarcinoma, which accounts for more than 90 percent of pancreatic cancers, Zheng and his colleagues also tracked down a link between the abundance of Sema3D in those tissues and the progression of metastatic pancreatic cancer.

Our results demonstrated the possibility of isolating highly metastatic breast CSCs using the hypoxia / reoxygenation regimen we established.

«Our findings have potential for targeting local, as well as metastatic tumors, and future studies will use FDA - approved drugs to induce Par - 4 secretion.»

The nanoparticles assemble themselves from zinc and a drug called oxaliplatin, which is widely used against advanced - stage metastatic colon cancer.

Merck's cancer drug Keytruda got the nod of U.S. regulators as a first - line drug for treating metastatic non-small cell lung cancer.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

The results of our in vitro experiments strongly suggest that miR - 7 plays a role in metastatic CSCs by modulating the expression of KLF4.

«We established an association of this variant with increased metastatic ability of p53 mutant cancers, which corresponds to a worse prognosis for breast cancer patients carrying p53 mutations, providing important information for the prognosis and treatment of these patients.»

A Randomized Phase 2 Study of Cediranib in Combination with Olaparib versus Olaparib Alone in Men with Metastatic Castration Resistant Prostate Cancer

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

A new phase 3 study in some of the most difficult - to - treat patients, women with endocrine - resistant disease, showed that the newly approved drug, palbociclib, more than doubled the time to cancer recurrence for women with hormone - receptor (HR +) positive metastatic breast cancer.

Research on metastatic colorectal cancer and sarcoma, however, suggests a potential benefit from adding local therapy — treatment directed specifically at the tumor cells — to the standard approach of systemic therapy.

Despite advances in managing and curing some forms of breast cancer, women whose disease becomes metastatic have fewer effective options.

«This finding suggests that local treatments, including radiation, could work in concert with chemotherapy to prolong the amount of time before recurrence occurs in patients with limited sites of metastatic NSCLC.»

Over the course of 16 days (including a weeklong break), they injected mice already infected with a highly metastatic form of pancreatic cancer with the «labeled» bacteria.

The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized.

The results of correlation analysis between miR - 7 and KLF4 indicate that there was a significant inverse correlation between these 2 genes in brain metastatic tissues (Fig. 6B).

Ohler C, Mughannam A, Reinke J, Spangler W. Transient hemi - inattention in a dog with metastatic renal hemangiosarcoma.

Meta - analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression - free and overall survival benchmarks for future phase II trials.

Mice injected with cancer cells that had increased activity in this gene were much more likely to develop metastatic growths than those given cells with low Arntl2 activity.

Two of the first dogs treated (one with metastatic carcinoma, one with undifferentiated sarcoma) had advanced cancer, and these dogs had remission of their cancer when receiving piroxicam, but no other treatment.

Specific locations are typically associated with more aggressive behavior with a higher metastatic potential such as in a digit, scrotum or oral cavity.

«Immunotherapy drug effective for metastatic triple negative breast cancer: Pembrolizumab shown to shrink tumors — regardless of whether patient had prior treatment.»

In some individuals there were significant genetic differences between tumor sites, suggesting early metastatic spread; in others, there was little difference between a primary tumor and its metastases.

These findings may lead to more effective treatment strategies against metastatic pancreatic cancer, which is universally lethal.

Researchers led by Van Allen and Choueiri sought an explanation for why some patients with a form of metastatic kidney cancer called clear cell renal cell cancer (ccRCC) gain clinical benefit — sometimes durable — from treatment with immune checkpoint inhibitors that block the PD - 1 checkpoint, while other patients don't.