Sentences with word «microcin»

«Proteins secreted by beneficial gut microbes shown to inhibit salmonella, invasive E. coli: Study finds that microcins help block illness - causing bacteria in inflamed intestines.»

In the journal Nature, Manuela Raffatellu, associate professor of microbiology & molecular genetics, and colleagues provide the first evidence that small protein molecules called microcins, produced by beneficial gut microbes, play a critical part in blocking certain illness - causing bacteria in inflamed intestines.

The presence of biosynthetic genes for bacteriocins is common to all genomes, except for microcin in UM270.

«We hypothesize that their role was missed because, as our data indicate, microcins do not seem effective in noninflamed intestines.

In their study, the researchers show that a probiotic strain of E. coli called Nissle 1917 utilizes microcins to inhibit the pathogen salmonella and an invasive form of E. coli (isolated from patients with inflammatory bowel disease).

As reported in the August issue of Applied and Environmental Microbiology, the Salmonella quickly developed defenses to the E. coli microcin.

The study also casts doubt on researchers» plans to employ special killer bacteria to combat infections, says microbiologist Herbert Schweizer at Colorado State University in Fort Collins, such as the use of microcin - secreting E. coli to treat Salmonella infections in chickens.

To test this, the researchers used two bacteria that both live in the gut: a strain of Escherichia coli that secretes microcin 24 and a Salmonella enterica strain that is susceptible to it.

A team led by microbiologist Steve Carlson at the U.S. Department of Agriculture's Agricultural Research Service lab in Ames, Iowa, was interested in harnessing microcins as antibiotics but wondered whether bacteria would eventually learn how to evade these too.

Researchers have accidentally discovered a surprising link between microcin B17, a toxin produced by E. coli, and inflammatory bowel disease.

In contrast, we show that in an inflamed intestine, microcins help a probiotic strain limit the growth of some harmful bacteria.»

«Although an in vivo role for microcins has been suggested for 40 years, it has never been convincingly demonstrated,» said Raffatellu, who's affiliated with UCI's Institute for Immunology.

She added that microcins are essential for the therapeutic activity of E. coli Nissle, and her next step is to purify microcins and test whether they can be given as targeted antibiotics.

Some species fight with an antimicrobial peptide called a microcin to which they are resistant themselves.

The explanation, the team figured, could be that the microcin turned on the so - called multiple antibiotic resistance system, a pump that some bacteria use to get rid of almost anything harmful.

Probiotics possess a powerful arsenal of their own and can produce various antimicrobials such as bacteriocins and microcins.