Sentences with word «microvesicles»

Review of «Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells» from STEM CELLS by Stuart P. Atkinson

Kulkarni R, Bajaj M, Ghode S, et al., Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells.

Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JF, Røe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V (2012) Immunogold detection of L - glutamate and D - serine in small synaptic - like microvesicles in adult hippocampal astrocytes Cereb Cortex, 22 (7), 1690 - 7 PubMed 21914633

NR2B particles face astrocytic processes (ast) that contain synaptic - like microvesicles (SLMVs, arrowheads in inset) in close proximity.

Besides messenger RNA, microvesicles also contain microRNA and proteins, providing information about both the transcriptional and regulatory environments of their parent cells.

To test their hunch, the researchers isolated microvesicles from 30 frozen tumor samples and looked for mRNA from a particular growth receptor unique to glioblastomas.

Previous research had analyzed the protein and lipid content of glioblastoma microvesicles.

«We kind of had this wild idea that because these tumor cells are just pouring [out microvesicles], maybe we can actually see it in the blood,» Breakefield says.

Their importance for communication between breast cancer cells prompted Johan Skog, a geneticist at Harvard Medical School in Boston, and colleagues to examine microvesicles secreted by glioblastoma, or brain tumor, cells.

The rejuvenation of aged HSCs occurred thanks to the intercellular transfer of large membrane - derived extracellular vesicles known as microvesicles (MVs) carrying autophagy - related mRNAs

She is TCD's Principal Investigator on SFI - supported Molecular Therapeutics for Cancer Ireland; Strand Leader of Irish Cancer Society - supported Breast - PREDICT; and P.I. and Chair, H2020 - supported European Network Cooperation in Science and Technology focussed on Exosomes & Microvesicles in Health & Disease which brings together researchers from around the world, in academia and industry.

Researchers discover that treatment with microvesicles from young MSCs can rejuvenate aged HSCs and potentially improve bone marrow transplantation outcomes

Now, new research from the laboratory of Vaijayanti P. Kale (National Centre for Cell Science, Pune, Maharashtra, India) has described a fascinating new approach to return lost functionality to aged mouse HSCs: the transfer of microvesicles (MVs) containing positive regulators of autophagy derived from young mesenchymal stem cells (MSCs)[6].

«There are these microvesicles called «exosomes» that are actually released from every living cell in the body.

Also covered will be techniques for analyzing exosomes, microvesicles, and apoptotic bodies in unprocessed samples, how imaging flow cytometry can be used to evaluate or reevaluate EV isolation techniques, and the advantages and disadvantages of using this method.

Extracellular vesicles (EVs) such as exosomes (70 nm — 160 nm in diameter) and microvesicles (100 nm — 1,000 nm diameter) can be harvested from cell - culture supernatants and from all bodily fluids.

Comparing proteins within the microvesicles with the originating tumors showed that the vesicles also accurately reveal the protein content of the tumors, providing still more information about how tumors might respond to specific therapies, the researchers report.

Previous research has shown that many cells, including cancer cells, communicate directly with one another by emitting tiny bubbles of cellular material called microvesicles.

Her research group focuses on diagnostic, prognostic and predictive biomarkers; discovering new therapeutic targets; cancer cells communication via exosomes, microvesicles and CTCs; elucidating and circumventing resistance to targets agents and classical chemotherapy; associations between obesity, metabolic syndrome and cancer.

Isolation of Exosomes and Microvesicles from Cell Culture Systems to Study Prion Transmission.

EVs can arise from endogenous production pathways (exosomes) or bud from the cell surface (ectosomes, or microvesicles).