Sentences with word «moiety»

Protein moiety of the HNRP particle has 6 major components called core proteins, and HNRPA1 is one of them.

Hydroxyl, amine and carboxyl moieties in proteins can be phosphorylated, which modifies the proteins to switch them on or off for various functions.

When the transcript of the M1 RNA gene is combined with the protein moiety not only is a tRNA precursor cleaved but also the precursor to 4.5 S RNA from Escherichia coli.

Significance of the carbohydrate moiety of the rat ovarian luteinizing - hormone / chorionic - gonadotropin receptor for ligand - binding specificity and signal transduction

Among the plethora of organic and inorganic chemical consolidants for gypsum that have been tested in our laboratory, many of them possess chemical moieties that are capable of interacting with surface calcium ions.

Major challenges in the development of drug delivery systems (DDSs) have been the short half - life... chemistry affects the PK profile and organ distribution of a gold nanoparticle - based DDS containing both a passive and active targeting moiety via... -LSB-...]

Peptides 9 - 13 displayed higher activities than both FC131 and FC122 (cf, Table 1 and Figure 5), indicating that the basic amidine moiety possesses the expected requirement to increase the affinity for the receptor.

«Influence of cholesterol sulfate and carbohydrate moieties on rabbit sperm penetration of zonae pellucidae»; The University of Georgia; 1987.

CXCR4 antagonists in which a substituted benzylic aminomethyl group or a heterocyclic aminomethyl moiety replacing the butyl amine residue showed potent antiviral activity [88].

In order to identify novel non-peptide CXCR4 ligands, the introduction of crucial functional moieties for receptor binding onto a bicyclic heterocyclic scaffold to mimic FC131's quite rigid backbone was carried out.

In its chloride salt form (methylene blue, or methylthioninium chloride (MTC)-RRB- it is an active moiety with a long history of use in the treatment of a variety of conditions.

Certain enzymes also serve as transport moieties for other substances, such as zinc, selenium, and magnesium.

«Specifically, we introduced an orthoquinone moiety to the PAC that possessed the most ideal switching properties under a redox reaction with hydrogen and oxygen gases.»

The organic chemists in the group then synthesized the disaccharide moiety on the terminus of arabinogalactan.

The researchers determined that iminopyrimidinones could bind in the same manner as the isothiourea moiety.

However, shogaols have a greater medicinal value due to the presence of alpha - and beta - unsaturated ketone moieties, which have both antioxidant and anti-inflammatory effects.

The presence of a glucose moiety compared with a galactose or arabinose on the cyanidin and peonidin anthocyanidins present in cranberry juice seems to make them more bioavailable as a percentage of the delivered dose (16).

«This makes the uranyl moiety very important, but also the universal view that the ITI was a niche concept of limited applicability dominated because it was restricted to high oxidation state actinide metals like uranium.

The versatility of HPLC in compound separation is due mainly to the availability of numerous chromatographic matrices (reversed - phase, normal phase, ion - exchange, ion - pair, and others), its reproducibility (peak performance and results), and its selectivity (compounds of specific moieties / structures).

The chromium ions are held in place by carboxylate moieties in a bidentate fashion, forming a rigid hexacarboxylate oxo - trinuclear chromium (III) cluster, ensureing that the resultant Cr - soc - MOF - 1 adsorbent possess the required hydrolytic stability.

Upon irradiation with ultraviolet (UV) light before deposition on graphene, the diazirine moiety is cleaved and a reactive carbene species is formed.

«The most important structural motif we introduced in these new molecules is the three - membered ring containing a nitrogen atom, a so - called aziridine moiety.»

The carbohydrate moiety associated with this residue, which is recognizable in the cryo - EM electron density, may function as an attachment site of the virus to host cells.

The P2 4 - aminomethylphenylalanine moiety of the inhibitor forms a salt - bridge with the nonconserved Asp83 of NS2B; ion - pairing between Asp83 and the P2 residue of the substrate likely accounts for the enzyme's high catalytic efficiency.

The substrate specificity of mammalian thioglycosidase involves both the aglycone and the glycosyl moieties.

The switch is derived from a compound classified as a hemithioindigo, in which a so - called thioindigo moiety is linked via a carbon double bond (C = C) and a single bond (C - C) to a planar aromatic ring.

«We could introduce different functional organic moieties to the present MOF and create materials with magnetic, electronic and photonic functionalities.»

When the furyl moiety was replaced with other aromatic groups, or when one of the benzene rings was removed, the cell division inhibitory activity was not observed, suggesting that a triarylmethane structure containing both the benzene and the furan rings are necessary for their bioactivity.

Some compounds containing the triarylmethane moiety are known to exhibit anticancer properties, and many new compounds have been synthesized to investigate their bioactivities.

The isoselenocynate moiety was designed based on naturally occurring isothiocyanates, which can be found in vegetables, such as broccoli and cauliflower, and are known for their cancer prevention properties.

The ZFP moieties (target gene; ZFP name; target sequence (5 ′ → 3 ′); recognition α - helices (finger number)-RRB- are as follows: CXCR4; X4 - ZFN - L; GTAGAAGCGGTC, DRSALSR (1), RSDDLTR (2), QSGNLAR (3), QSGSLTR (4); CXCR4; X4 - ZFN - R; GACTTGTGGGTG, RSDSLLR (1), RSDHLTT (2), RSDSLSA (3), DRSNLTR (4).

In their demonstration of a mechanically facilitated reaction, Christopher Bielawski and colleagues at the University of Texas at Austin, focused on the highly inert 1,2,3 - triazole moiety.

Furthermore, by using a digestive enzyme specific for cutting the arabinogalactan sugar chain at various sections, the group was able to identify that a disaccharide moiety containing a methyl - glucuronic acid unit located at the terminus of arabinogalactan, was essential for AMOR's activity.

They suggested their remarkable yellow crystals consisted of two cyclopentadiene moieties each making a single bond to a central iron atom.

The optimal spacer length between the benzimidazole N - 1 and the basic nitrogen is a 3 - carbon propylene moiety (e.g. 49), while shorter (2 carbon) or longer (4 - 5 carbon) linkers result in 5 to 10-fold lower anti-HIV activity.

As expected, such studies confirmed that three functional groups on the indole moiety properly overlapped the three pharmacophore residues of the parent compound.

Finally, the replacement of the pyridine ring with a pyrazine moiety (compound 164) conferred an antiviral potency comparable to that of the benzyl analogue 157.

The introduction of a 2,3 - disubstituted pyridine ring with an aminomethyl moiety at the 2 - position led to compound 142 with an IC50 value of 0.021 μM that showed a comparable potency to 131.

Since it is plausible that the unfavorable pharmacokinetic profile of 182a is due to a rapid oxidative metabolism, a series of derivatives functionalized with electron deficient moieties on the terminal aromatic ring were synthesized.

As a further step, attention has been paid to the «left - hand» ring by replacing each amine groups with suitable moieties.

A substitution at the 6 - position of compound 93 with either an H - bond donor (amino, 96) or H - bond acceptor (methoxymethyl, 97) moiety resulted in a significant reduction of potency, while substitution at the 3 - position was well tolerated (90, 97 - 102).

Interest was triggered by the fact that 5,6 - dimethylbenzimidazole is a component of vitamin B12 and several antihelminthic, antacid and antibacterial drugs have benzimidazole moieties.

The introduction of an aminomethyl moiety led to the active compound 135 with an IC50 value of 2 nM.

The substitution of the Arg3 - Nal4 dipeptide with the (Z)- fluoroalkene moiety in compound 8 also led to the loss of CXCR4 - binding activity (IC50 (7,8) > 10 μM).

In general, the phenylguanides were more active than either the guanides or biguanides, suggesting that an increase of the binding affinity for CXCR4 could be reached by using a larger aromatic moiety.

In order to explore new pharmacophore moieties, FC131 was used as a lead compound for the development of novel CXCR4 antagonists.

Compounds 166 (containing a phenyl moiety) and 167 (containing an exocyclic - pyridine fused group), and the alkyl analog 168, retained activity (EC50 values of 0.040, 0.104 and 0.043 μM, respectively).

A comparable potency was achieved by incorporation of a hydroxymethyl or methoxymethyl moiety (compounds 136 and 137), even though the permeability was not improved.