Sentences with phrase «mouse models of autism»

Some of the most commonly used mouse models of autism are knockout mice, which are engineered so that certain genes are either missing or turned off.

We will present data obtained with mouse models of autism, that demonstrate the utility of the system.

Neunuebel's new lab at UD is looking at social communication in mouse models of autism.

To study the relationship between autism and subplate neuron development in mice, Kanold, Nagode and their collaborators began with a well - established mouse model of autism.

«Mouse model of autism offers insights to human patients, potential drug targets.»

By demonstrating that a widely used mouse model of autism does have gastrointestinal problems, and that these problems are associated with behavioral symptoms, the new research «shows us something fabulous,» says Betty Diamond, an immunologist at the Feinstein Institute for Medical Research in Manhasset, New York.

The new findings are part of a bigger study where Abel and his colleagues are investigating many different mouse models of autism, in which different autism - linked genes have been disrupted.

Dodero, L., Damiano, M., Galbusera, A. Bifone, A., Tsaftsaris, S.A., Scattoni, M.L., Gozzi, A * Neuroimaging Evidence of Major Morpho - Anatomical and Functional Abnormalities in the BTBR T+TF / J Mouse Model of Autism.

Brunner D., Kabitzke P., He D., Cox K., Thiede L., Hanania T., He D., Sabath E., Alexandrov V., Saxe M., Peles E., Mills A., Spooren W., Ghosh A., Feliciano P., Benedetti M., Clayton AL., Biemans B. Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.

* «Social deficits in Shank3 - deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition» by Luye Qin et al. will be published in Nature Neuroscience on Monday 12 March 2018.

In the future, the researchers are interested in examining how the neural substrates of social and spatial learning differ in mouse models of autism.

Researchers Daniel Nagode and Patrick Kanold, together with their colleagues, used a well - established mouse model of autism, which involves injecting valproic acid (VPA) on mouse embryos during day 12 of their 20 - day gestational period.

New research in a mouse model of autism showed that such low glycemic index diets, similar to the plans that people with diabetes follow to keep their blood sugar in check, reduced symptoms of the disorder in mice.

In the new study, the Salk scientists used a mouse model of autism — an inbred strain of mouse previously found to display autism - like symptoms — to ask whether lowering the level of dicarbonyl methylglyoxal (a common byproduct of sugar metabolism) could alleviate symptoms of autism in the animals.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

In a study published earlier this year, Jiang and other collaborators at Duke described a mouse model of autism in which they deleted a prominent autism gene called SHANK3, which is mutated in 1 percent of people with the disorder.

This is the first time they have used optogenetics to manipulate social behavior in a mouse model of autism.

Turning on a set of neurons that dampen brain activity improves social behavior in a mouse model of autism; turning off neurons that excite brain activity does the same thing.

To explore that question, Mazmanian and colleagues at Caltech used a mouse model of autism that is thought to approximately recreate three of the disorder's hallmark deficits: lack of social interaction, decreased communication (mice normally emit ultrasonic, birdsonglike chirps), and repetitive behaviors such as compulsive grooming or burying marbles.

«This is some of the first evidence in a mouse model of autism of a «female protective effect,» from the behavioral to the molecular level,» says Nicola Grissom, first author of the study who is now an assistant professor of psychology at the University of Minnesota.

The mouse model of autism used by the research team is missing the same stretch of DNA.

«Autism - linked gene stunts developing dendrites: Genetic variation leads to excessive pruning of dendrites in rats cells and mouse model of autism.»

Huber, K.M., Klann, E., Costa - Mattioli, M., and Zukin, R.S. (2015) Dysregulation of mammalian target of rapamycin signaling in mouse models of autism.