Sentences with word «nanodisc»

They used cryo - EM analysis to decipher the engineered ATP synthase, which was synthesized in yeast and reconstituted into nanodiscs to allow for structural analysis.

Elimination of established tumors with nanodisc - based combination chemoimmunotherapy - Science Advances

To investigate how the timing of the quorum sensing was linked to the receptor kinases, the researchers developed so - called nanodiscs allowed them to observe how Agr kinases operate in a cell - like environment.

Researchers at the University of Michigan have had initial success in mice using nanodiscs to deliver a customized therapeutic vaccine for the treatment of colon and melanoma cancer tumors.

Marassi's lab developed methods for reconstituting BCL - 2 proteins in lipid bilayer nanodiscs that mimic the mitochondrial outer membrane.

«The idea is that these vaccine nanodiscs will trigger the immune system to fight the existing cancer cells in a personalized manner,» Moon said.

Hamers says nanodiscs could shed light on the biochemical behavior of a host of membrane proteins that have escaped detailed understanding.

At a meeting here last week of the Materials Research Society, Stephen Sligar, a biochemist at the University of Illinois, Urbana - Champaign, reported that he and his colleagues have ensconced individual membrane - bound receptors in lipid - based nanodiscs.

The receptor - containing nanodiscs were then placed in a special orientation on a carbon nanotube transistor, completing the bioelectronic nose.

Dr Miroshnichenko, in collaboration with colleagues from Germany and Singapore, successfully tested his new theory with a single silicon nanodiscs between 160 and 310 nanometres in diameter and 50 nanometres high, which he was able to make effectively invisible by cancelling the disc's scattering of visible light.

The therapeutic cancer vaccine employs nanodiscs loaded with tumor neoantigens, which are unique mutations found in tumor cells.

«Nanodiscs deliver personalized cancer therapy to immune system.»

Next, Hafenstein's group plans to use a larger nanodisc to capture the process of the virus interacting with the mock membrane.

So, Seunghun Hong, Tai Hyun Park and colleagues wanted to see if they could put the receptor into nanodiscs to create a sensitive and specific detector for cadaverine.

In the new experiment, Hafenstein and her coinvestigators simulated the surface of a cell by using mock membranes called nanodiscs.

Solution - NMR characterization of outer - membrane protein A from E. coli in lipid bilayer nanodiscs and detergent micelles.

Using the nanodiscs, the team elucidated the activation mechanism of receptor kinase AgrC and discovered a key regulatory hotspot in the kinase that could greatly affect its activity.

To demonstrate that receptors still function inside the nanodisc, Sligar's graduate student Andrew Leitz turned to a well - known protein: the β2 adrenergic receptor (β2AR), a target of heart drugs called beta blockers.

One way to do this is to make the protein in a bacterial cell and reconstitute it in nanodiscs, which are water friendly, membrane - like structures that the receptor can reside in.

The researchers successfully produced copies of the receptor in E. coli and assembled them into nanodiscs.

«We are basically educating the immune system with these nanodiscs so that immune cells can attack cancer cells in a personalized manner,» said James Moon, the John Gideon Searle assistant professor of pharmaceutical sciences and biomedical engineering.

When combined with immune checkpoint inhibitors, an existing technology that amplifies T - cell tumor - fighting responses, the nanodisc technology killed tumors within 10 days of treatment in the majority of the mice.

The nanodisc technology was tested in mice with established melanoma and colon cancer tumors.

«In our experiment, it buried its tail into the nanodisc, giving us a mock membrane displaying the appropriate receptor to bind to the virus.»

They inserted human cell receptors — protein molecules that let outside signals into the cell — into the nanodiscs, the first time this has been done to capture a virus capsid.

«Because the nanodiscs in this set of experiments were so small, we're not getting the best picture of the interaction, and that's one place to improve,» she said.