Sentences with word «nigrostriatal»
Parkinson's disease (PD) is a progressive neurodegenerative disease characterised by motor and non-motor symptoms, resulting from the degeneration of nigrostriatal dopaminergic neurons and peripheral autonomic neurons.
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«One possible explanation is that UPDRS reflects primarily deficits arising from nigrostriatal degeneration, whereas CSF α - synuclein levels are influenced by the whole brain and may serve as a proxy for total brain pathology,» says Dr. Zhang.
Unilateral nigrostriatal 6 - hydroxydopamine lesions in mice II: predicting l - DOPA - induceddyskinesia
Chronic Δ ⁹ - tetrahydrocannabinol exposure induces a sensitization of dopamine D ₂ / ₃ receptors in the mesoaccumbens and nigrostriatal systems
The Toll - Like Receptor - 3 Agonist Polyinosinic: Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration
Why it matters: Parkinson's disease is marked by the loss of dopamine in the brain's nigrostriatal neural pathway, which is one of four major pathways for this hormone and neurotransmitter in the brain; the disease primarily affects part of the motor system involved in the production and coordination of movement.
Progressive behavioral deficits in DJ -1-deficient mice are associated with normal nigrostriatal function
«Nigrostriatal Catecholamine Metabolism in Guinea Pigs is Altered by Purine Enzyme Inhibition,» in Experimental Brain Research (with W. Church), (1999)
Unilateral nigrostriatal 6 - hydroxydopamine lesions in mice II: predicting l - DOPA - induced dyskinesia
«The mechanism that can probably explain the immediate mood - lifting effect of immersion in cold water or cold shower is probably the stimulation of the dopaminergic transmission in the mesocorticolimbic and nigrostriatal pathway,» Shevchuk said in a 2008 podcast with Neuroscene.
The integrity of the nigrostriatal dopamine pathway can be assessed using single photon emission computed tomography (SPECT) with dopamine transporter (DaT) radioligands.