Sentences with phrase «novel therapeutic targets»
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
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The goal of this work is to develop novel therapeutic targets based on increased understanding of the interaction of tumor cells and immune cells.
Several novel therapeutic targets have already been identified, and drug discovery efforts continue.
Because of the ease with which the CRISPR / Cas9 system can be applied, it has quickly become a robust tool for generating accurate genetic disease models in the laboratory and for identifying novel therapeutic targets in the clinic.
As an investigator in TGen's Pharmaceutical Genomics Division, Dr. Azorsa applied siRNA screening to identify novel therapeutic targets in cancer as well as functionally relevant gene targets that modulate drug response.
Besides enabling patient stratification, our study allows the identification of novel therapeutic targets for obesity.
However, much less information is available for miRNA in cancer stem cells, particularly in relation to the metastatic ability of CSCs in breast cancer, and therefore, it is of significant interest to identify such miRNAs that may serve as novel therapeutic targets for metastatic breast cancer.
The RNA pieces, called «long non-coding RNAs» or «lncRNAs,» help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeutic targets to promote skin repair.
«We believe the use of this index in future studies may help identify novel therapeutic targets against cancer,» Noushmehr said.
«While we need to better understand how these abnormally regulated metabolites activate oncogenic proteins, our intriguing discovery suggests novel therapeutic targets for this disease,» says principal investigator and study leader Arnab Chakravarti, MD, chair and professor of Radiation Oncology and co-director of the Brain Tumor Program at the OSUCCC — James.
«Novel therapeutic target discovered for estrogen receptor positive (ER +) breast cancer.»
These findings establish Frizzled family receptors as disease - relevant receptors for toxin B in the colonic epithelium and provide novel therapeutic targets for treating C. difficile infections.
This model will subsequently be used to find novel therapeutic targets, to guide genetic screening to identify individuals with elevated risk for developing colorectal cancer and to classify patients into sub-groups to select the treatment combination that is optimal for each patient (personalised medicine).
The publication, «Androgens Regulate Prostate Cancer Cell Growth via an AMPK - PGC - 1α - Mediated Metabolic Switch,» featured online in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target.
These proteins, if their roles in neuroprotection in the retina are fully established in the future by more comprehensive studies, may present novel therapeutic targets in treating retinal disorders including glaucomatous conditions.»
Carmot's vision is to become a leader in drug discovery by unlocking novel therapeutic target space not currently accessible to conventional small molecule technologies.
AAF Extension Awards support the advancement of novel therapeutic targets stemming from AAF - funded research.
SEngine Precision Medicine has already identified, validated, and patented novel therapeutic targets that DNA sequencing alone can not reveal.
«We believe the use of this index in future studies may help identify novel therapeutic targets against cancer,» Dr. Noushmehr said.
Currently we are using this system for identification of novel therapeutic targets and for screening and characterization of the effects of anti-diabetic drugs.
They hypothesize that this RNA will provide novel therapeutic targets for suppression of the abnormal HD protein and, therefore, will be an effective treatment of HD.
A deeper understanding of these axes provides a new framework for developing novel therapeutic targets and optimising personalised interventions.
Research released today highlights advances in the use of CRISPR - Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction.
From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.
«Novel therapeutic targets for Huntington's disease discovered.»
«This finding suggests a novel therapeutic target to decrease invasion of tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.
Remarkably, when the researchers manipulated the activity of these three genes, almost all of the other genes in the network were corrected, pointing to novel therapeutic targets for CAVD.
A better understanding of the function of neuromodulators, such as COX - 2 and TIA - 1, may help identify novel therapeutic targets for the treatment of epilepsy.»
«We have identified a novel therapeutic target for the treatment of severe influenza that is effective under conditions where known antiviral drugs fail to protect from death.»
Further exploration of the TCA cycle, using metabolomics, may identify novel therapeutic targets for CKD and in turn may help us evaluate the effects of promising interventions.»
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Other researchers at Joslin are conducting large scale genetic screening for novel therapeutic targets to control autoimmunity, which will complement the effort of BAIRT to extend autologous beta cell replacement to patients with type 1 diabetes.
The SMA Foundation has invested over $ 85M in basic and translational research aimed at understanding the biology of SMA pathogenesis, identifying novel therapeutic targets, and developing research tools to systematically and efficiently determine the efficacy of potential treatments.
Translation of these fundamental discoveries has enabled gene - based diagnosis and novel therapeutic targets.
CellR4 is particularly interested in therapies and diagnostics, including all aspects of translation from bench to bedside: identification of novel therapeutic targets, epidemiology, clinical trials, drug safety, and meta - analyses.
If so, it could represent a novel therapeutic target.
Novel therapeutic targets will be suggested.
«The results present a compelling starting point for the use of this method in larger studies and provide insights for novel therapeutic targets.»
In parallel, I aim at identifying novel therapeutic targets and candidate drugs, and test them empirically.
Thus, our group aims to discover novel therapeutic targets for type 1, type 2 and gestational diabetes by investigating the role of beta cell mass and function at distinct stages of diabetes pathogenesis and therapy.
We are looking at the role of complement proteins in inflammatory diseases such as atherosclerosis, to identify novel therapeutic targets.
This nutrient sensor may represent a novel therapeutic target for controlling mTORC1, whose activity is often dysregulated in a variety of diseases, including diabetes and cancer.
Two new precision medicine tests that look beyond cancer genes to identify novel therapeutic targets have just received New York State Department of Health approval and are now available to both oncologists and cancer researchers for use at the front lines of patient care.
Mapping the epigenome will allow Vijay and his team to zoom in on those genes with the greatest likelihood to contribute to disease, and the cell types in which they act, and therefore will help identify novel therapeutic targets.
His research focuses on studying the role that SUMOylation (a protein modification pathway) plays in Huntington's disease, with hopes of targeting the SUMO pathway to identify novel therapeutic targets.