Sentences with phrase «of aneuploidy»

Consistent with the observed consequences of aneuploidy in S. cerevisiae, all aneuploid C. neoformans strains in our study exhibited a TS phenotype (Figure 3A).

Here we use two different mutant conditions to address the consequences of aneuploidy during tissue development and homeostasis in Drosophila.

To ensure the response is not an effect that is unique to baker's yeast cells, the researchers then studied the impact of aneuploidy on mice, and found the same levels of variability, Amon says.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

In research funded by the Wellcome Trust, Professor Zernicka - Goetz and colleagues developed a mouse model of aneuploidy by mixing 8 - cell stage mouse embryos in which the cells were normal with embryos in which the cells were abnormal.

It is here that he has refined his theory of aneuploidy as the cause of cancer.

Age is the best predictor of aneuploidy and a major factor to consider when thinking about aneuploidy.

The common clinical scenarios of age - related infertility, miscarriage, and Down Syndrome are all expressions of aneuploidy.

In milder forms of aneuploidy, embryos can survive longer, with a few continuing on into pregnancy, accounting for common problems like Down Syndrome.

PFC offers CCS as an option for patients undergoing in vitro fertilization (IVF), as a treatment for recurrent miscarriage, prevention of aneuploidy in pregnancy, and for women that wish to improve implantation rates, reduce miscarriage rates, and reduce the risk of multiple pregnancy after IVF.

A high degree of aneuploidy is a feature of high - grade tumors and is associated with poor prognosis.

But even before he reaches the safety of the sidewalk, he has resumed his explanation of aneuploidy, the basis of his theory about the cause of cancer.

They found that here too, the effects of aneuploidy were varied across otherwise identical cells.

The role of aneuploidy — in which entire chromosomes or chromosome arms are added or deleted — has remained largely unstudied.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

Writing in the journal Scientific Reports, Dr Gary Kerr and colleagues stated: «Understanding how meiosis is regulated is of great importance to understanding the causes of aneuploidy and genetic disorders in humans.»

The team's new insights will allow a new medical evaluation of aneuploidy, which is associated with certain diseases when it occurs in multicellular organisms.

Now, a team at Harvard Medical School has devised a way to understand patterns of aneuploidy in tumors and predict which genes in the affected chromosomes are likely to be cancer suppressors or promoters.

Prof. Dr. Rudi Balling, director of LCSB, explains the medical implications of the new insights: «We have long known of aneuploidy in multicellular organisms.

«It's probably the only convincing demonstration of an environmental effect on the frequency of aneuploidy,» says Dorothy Warburton, a cytogeneticist at Columbia University in New York City who has studied aneuploidy extensively.

The risk of aneuploidy increases as a woman gets older.

«An interesting feature of aneuploidy is it can be temporary,» said Heitman.

Despite the prevalence of aneuploidy in cancer, its functional consequences for cell physiology remain poorly understood.

We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.

This discovery is important not only for understanding the origin of aneuploidy in sperm, but also for understanding how cells repair DNA, which is important because although errors in DNA repair can lead to cancer - causing mutations, they can also be exploited for the treatment of cancer.

Thus, the specific consequences of aneuploidy may differ between even closely related lineages.

Researchers at the Department of Physiology, Development and Neuroscience at Cambridge report a mouse model of aneuploidy, where some cells in the embryo contain an abnormal number of chromosomes.

Given the finding that aneuploidy can underlie and drive adaptive evolution in S. cerevisiae, C. albicans, C. neoformans, and Leishmania, it seems likely that beneficial impacts of aneuploidy may be even more ubiquitous and remain to be discovered in other saprobic and pathogenic eukaryotic microbes.

Sheltzer, J. M. and Torres, E. M. and Dunham, M. J. and Amon, A. (2012) Transcriptional consequences of aneuploidy.