Sentences with phrase «of animal models»

Her research interests are focused on understanding the molecular mechanisms that regulate retinal tissue regeneration in a variety of animal models.

In this review, the authors summarize the importance of animal models for research on schizophrenia.

The lack of an animal model has also prevented scientists from testing and fine - tuning experimental therapies for people.

For example resources that aid in the development of animal models.

Our lab makes use of animal models of either physiological or pathological remodeling to study the underlying molecular pathways of these remodeling responses.

There is strong and vocal opposition not just to research with non-human primates but to the use of all animal models in scientific research.

After working for several decades in upstate New York doing non-invasive studies of animal models of inherited bleeding diseases, she moved to southern California in 1986 to start Hemopet, the first non-profit national animal blood bank.

PHENOMIN constitutes a unique distributed resource for the creation, the care, the phenotyping, the distribution and archiving of animal models for academics and private corporations.

Godwin's findings are a validation of the MDI Biological Laboratory's unique research approach, which is focused on studying regeneration in a diverse range of animal models with the goal of gaining insight into how to trigger dormant genetic pathways for regeneration in humans.

CRISPR / Cas9 bursts the world of animal models wide open.

A model of dengue infection in humans is one way to overcome the absence of animal models and the challenge of high background immunity in endemic areas.

Acetylcholinesterase inhibitors have been demonstrated to improve learning and memory in a number of animal models of cognitive dysfunction, as well as being a standard of treatment in patients exhibiting clinical signs of memory loss.

This well run mouse study shows the usefulness of animal models of HD, where we can experiment with these kinds of ideas that would be too expensive or ethically challenging to do in human HD patients.

I recently challenged my laboratory staff to think of animal models that could teach us about the biology of joyfulness, if not long - lasting happiness.

«For the first time, we can provide a complete description of an animal model from genes to behavior — including at the level of neuronal network activity, which has been ignored in most studies to date.»

The researchers now plan to test whether ebselen can protect the brains of animal models of stroke.

In research, monitoring and analysis of animal model behavior is often a stumbling block because it is difficult to do consistently and efficiently, Fallon said.

Our conversations often begin with discussions of animal models being used, desired phenotype and dietary requirements.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

We were able to cure cancer in 20 to 60 per cent of our animal models,» adds Mahoney.

«It has the potential to inform clinical practice and also guides us about the relevance of animal models of human disease and how we can reduce and refine their use.»

«It's a dramatic increase in lifespan of animal models, as much as 25 percent,» said Leyuan Liu, PhD, assistant professor at the Texas A&M Institute of Biosciences and Technology's Center for Translational Cancer Research.

With the help of an animal model, the researchers from Skintegrity discovered that fine nerve bundles change drastically if they are injured when a skin wound occurs.

«Many neuroscientists are uncomfortable with open discussion of human specializations for fear that the adequacy of their animal model will be called into question,» Preuss says, «so more research of this type would be informative.»

Present use cases for the utility of animal models for identifying targets for precision therapies

After observing the transformation in a petri dish, they injected these cells into the livers of animal models to see if the transformation could become complete.

The assessment of social behavior has become critical for the phenotyping of animals models of autism and schizophrenia.

Title: Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia Author: M. Pollard et al..

Broadly, the scope of our capabilities include, but are not limited to: (1) determination of optimal route and dose for pathogen challenge, (2) determination of correlates of immunity, (3) standardization of animal models for use in «Proof - of - Concept» efficacy studies of candidate vaccines, therapeutics and immunotherapeutics and (5) toxicity and efficacy of candidate molecules or vaccines in small animal models of infectious disease.

The track record of animal models for predicting therapies that will work in people has been poor, making drug discovery for neurodegenerative diseases very costly — and therefore less attractive to drug companies.

Enhanced Expression of Myristoylated Alanine — Rich C Kinase Substrate (MARCKS) in Airway Epithelium of an Animal Model of Allergic Airway Inflammation and Human Patients with COPD

Due to the capacities of the 15 partner centers, CELPHEDIA covers 3 big families of animal models: non mammalians, rodents and non-human primates.

The mini brains are derived from human stem cells thus, may be used instead of animal models to test new drugs, revolutionizing the way lab experiments work.

Dr. Ressler's Neurobiology of Fear Laboratory, founded in 2001 at Emory University and relocated to McLean Hospital in 2015, investigates the molecular, genetic, epigenetic, and neural circuit mechanisms underlying fear processes through an integration of animal models and human genetic research.

Importance of animal models in schizophrenia research.

Critically, the scientists confirmed that this biological pathway is identical in animal models and in the human disease cells in a dish, forwshadowing the potential future elimination of animal model testing for ALS and other diseases.

This includes the generation of animal models containing patient - derived tumor tissue to evaluate the sensitivity of genomically targeted drugs.

• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.

Establish continuity of your animal models across all facilities worldwide and across therapeutic areas by using the same OpenSource Diets.

I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.

Laboratory of Animal Models.

I am particularly pleased that the fundamental knowledge of gene function and the derivation of animal models of human disease are underpinning important therapeutic advances.