Sentences with phrase «of drug candidates»

That makes it relatively simple to gauge the effectiveness of large numbers of drug candidates in treating a condition caused by a particular mutation.

The essential protective function of this barrier is also a red light for 98 % of drug candidates for the treatment of the central nervous system.

And this enables scientists to narrow their field of drugs candidates rapidly, ultimately bringing forth development candidates that can advance into and through the clinical development process.

Gottesfeld's laboratory has been deeply involved in Friedreich's ataxia research, and has already performed work on the initial development of a drug candidate now about to be tested in clinical trials by Repligen Corporation.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

A new study, co-led by Patrick R. Griffin, a professor on the Florida campus of The Scripps Research Institute (TSRI), and B. Lecka - Czernik, a professor at the University of Toledo, has shown that a new class of drug candidates developed at TSRI increases bone mass by expanding bone formation (deposition of new bone) and bone turnover (a normal process of replacement of old bone).

About 40 percent of newly marketed drugs have poor solubility and more than 80 percent of drug candidates in the R&D pipeline fail because of solubility problems.

Weikop, P.; Egestad, B.; Kehr, J. Application of triple - probe microdialysis for fast pharmacokinetic / pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain.

Our industry - leading technology, invented by GigaGen's co-founders, interrogates immune systems with unprecedented depth and breadth — radically accelerating the selection of drug targets, identification of drug candidates and assessment of pre-clinical drug efficacy.

In 2008, Ernst and Young ranked Denmark first out of 15 European countries in pipeline growth, with a 23 percent increase from 2006 to 2007 in the number of drug candidates in development.

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

He was trying to solve his company's — which is also the industry's — «failure problem,» which is summed up by the fact that 90 % of drug candidates fail to make it to market.

Researchers from the UK and Denmark have developed a new method to predict the physical stability of drug candidates, which could help with the development of new and more effective medicines for patients.

The company expects that by 2010 up to a quarter of drug candidates will be biological therapeutic agents, said AstraZeneca's chief executive officer David Brennan in a statement.

Alzheimer's is a disease for which there are still no treatments that fundamentally alter the course of the disease, as trial after trial of drug candidates have ended in failure.

It hasn't revealed which modified nucleoside is in its newest generation of drug candidates.

And last month, at the annual J.P. Morgan Healthcare Conference in San Francisco, California, CEO Stéphane Bancel unveiled Moderna's first round of drug candidates, which include vaccines for Zika and flu, and a therapy for heart failure.

DNDi conducted the STORM - C - 1 open label trial to assess the efficacy, safety, tolerance and pharmacokinetics of the drug candidate ravidasvir combined with sofosbuvir.

Therefore, FDA is encouraging industry to use existing knowledge to do earlier stage simulations of the absorption, metabolism, and excretion of drug candidates.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

Many of these drug candidates possess examples of a phenomenon known as atropisomerism.

Our technology enables us to both identify a wide spectrum of drug candidates and analyze pre-clinical efficacy at an unprecedented scale.

GigaGen exhaustively tests combinations of these drug candidates in different cancer types to identify and develop the best clinical combinations for each patient.

Kancera AB is a biotechnology company that focuses on the development and sale of drug candidates that have the potential to cure or stop the progression of cancer.

Proclara has developed a pipeline of drug candidates that use GAIM to target the common amyloid protein conformation, dissociating and preventing the formation of misfolded protein assemblies, and blocking the cell - to - cell transmission of toxic aggregates.

The platform — whose effectiveness is described in dual papers published online this week in the journal Science — could accelerate the discovery of drug candidates that address the underlying pathology of Parkinson's and other neurodegenerative diseases.

We currently evaluate the therapeutic benefits as well as the toxicity of drug candidates in spheroids by means of conventional fluorescence microscopy as well as LSFM and many different biochemical and molecular biology - based assays (Ansari et al. 2013; Wenzel et al. 2014; Pampaloni & Stelzer 2010).

Assays for the identification and prioritization of drug candidates for spinal muscular atrophy.

BOSTON, Mass. — Emulate, Inc. announced today that it has formed a strategic partnership with F Hoffman La - Roche AG (Roche) that will use Emulate's Human Emulation System across R&D programs to enable more human - relevant studies that will lead to earlier and better prediction of safety and efficacy of drug candidates.

It is hoped that one more of these drugs candidates will significantly reduce the devastating effects of SMA in patients.

Recently, researchers are turning to these traditional remedies in search of drug candidates to treat dementia and neurodegenerative diseases.

Its products includes of drug candidates of therapeutic areas, including oncology, pain, anti-infectives, anti-viral and immunology.

Hands - on Group leader / Associate director to support DMPK - clinical pharmacolgy of drug candidate from drug discovery to Phase I / II clinical studies

Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory have played a key role in discovering a new class of drug candidates that hold promise to combat antibiotic resistance.

We are indebted to my colleague, Nancy Kuntz, MD, and co-author laboratories of Drs. Jasbir Singh and Mike Kiledjian along with Repligen and Families of Spinal Muscular Atrophy (FSMA), who initiated the development of this drug candidate.

More than 80 percent of all drug candidates in the pharma R&D suffer from poor solubility and are therefore rejected early in the drug discovery process.

Tropsha now develops models to test the relation between structure and activity of drug candidates and studies protein folding and the effects of mutations on protein structure.

Our proprietary antibody discovery technology quickly characterizes every cell in complex immune systems, powering our selection of drug targets, identification of drug candidates and preclinical assessment of efficacy.

Combinatorial chemistry allows a large number of drug candidates — nucleic acids, peptides and small organic molecules — to be screened simultaneously.

After the purchase, Amgen began evaluating all of its drug candidates against deCode's database.

Each of the drug candidates contained in the collection consists of a stable ring - shaped basic structure borrowed from the work of Manfred Mutter from the University of Lausanne.

The new process, called Extensive Combinatorial Refinement (ExCoR), could help improve the development of drug candidates that depend to a great degree on detailed structural analysis to determine how they work against specific disease targets.

This class of drug candidates has gathered wide attention as a causal means to induce tumor cell apoptosis [11, 12].

Nektar Therapeutics, Inc. is clinical - stage biopharmaceutical Company, which is engaged in the development of drug candidates that utilize its PEGylation & advanced polymer conjugate technology platforms.