Sentences with phrase «of drug targets»

It can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

The search provides the names of drugs targeted to each gene and details whether the drug is an inhibitor, antibody, vaccine or another type.

80 percent of all current drugs affect membrane proteins, and more than 50 percent of all drugs target them directly.

Friedman notes that, even with the increasing number of drugs targeting specific molecular abnormalities that drive tumor growth, most patients are only treated with one such drug at a time.

Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors.

«Although it is unknown how the genes regulate blood pressure,» Zhu added, «our findings contribute to better understanding of blood pressure pathways that can lead to future development of drug target for hypertension and may guide therapy for clinical care.»

One of the most exciting recent advances in clinical cancer research was the discovery that this subgroup of patients respond — sometimes dramatically — to a new class of drugs targeting the MAPK pathway through which BRAF signals.

Poly (ADP - ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target PARP - 1 remains to be clinically evaluated in this context.

In this role, she focuses on the development of biologically relevant high throughput biochemical and phenotypic assays to enable high throughput screening (HTS) for a variety of drug targets for psychiatric disorders, and is currently interested in developing a high throughput calcium dynamics assay to monitor synaptic networks.

Our industry - leading technology, invented by GigaGen's co-founders, interrogates immune systems with unprecedented depth and breadth — radically accelerating the selection of drug targets, identification of drug candidates and assessment of pre-clinical drug efficacy.

Other trials of this drug target in lung cancer have not worked, and the drugs» effects in colorectal cancer are also questionable, Stambolic says.

The study underlines how investigations into the basic biological function of a drug target can lead in unexpected directions.»

«Remarkably, our survey of drugs targeted to these proteins shows there are over 200 drugs already on the market that act against the first neighbour proteins we have identified, but that haven't been used for cancer treatments.»

Now, instead of our drugs targeting only diseased cells, we can target the immune system and provoke cells of the immune system to do the job for us,» said E. John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.

The authors urge utmost caution in the dosage of drugs targeting BACE1 in order to achieve a therapeutic window that balances both safety and efficacy.

«The supercomputing power of Titan allowed us to perform large - scale simulations of the drug targets and to screen many potential compounds quickly,» said Helen Zgurskaya, head of OU's Antibiotic Discovery and Resistance Group, who led the study.

Now a new study has shown that microorganisms can use a temporary silencing of drug targets — known as epimutations — to gain the benefits of drug resistance without the commitment.

Because IBD is a clinically heterogeneous disease with complex mechanisms, a combination of drugs targeting distinct biomarkers might be considered as a potential approach.

«Depending on how this mouse turns out,» he says, «we may put NAMPT on the list of drug targets, as well.»

The DBSR provides expert advice, technological and experimental support for conducting molecular assays of drug targets and drug activity within prospective clinical trials, to facilitate the research of Cancer Center members and other St. Jude investigators.

For many medications, inherited differences in patients» ability to metabolize, transport, and eliminate drugs and in the characteristics of drug targets and receptors are significant determinants of therapeutic or adverse effects of medications.

The expense and effort are increased by the FDA requirement that any company applying for approval of a drug targeted against a specific gene - driven abnormality must also produce a diagnostic test for that abnormality.

By isolating drug resistant bacteria, Matthew's work focuses on the identification and characterization of drug targets and mechanisms of drug resistance.

Second, even if these pathways are important, the other effects of drugs targeting these pathways may make it difficult to use them in Huntington's disease.

Metabolic profiling enhances drug target identification and validation by uncovering a comprehensive picture of drug target interactions across human metabolism - even at the preclinical stage.

Career Goals: I plan to pursue a career in scientific research focusing on the discovery of drug targets to improve the treatment options of human immunological diseases and cancer.

Remarkable new tools, made possible by dCas9, are coming to fruition that will allow for a new kind of interrogation of gene function, allowing us to ask more sophisticated questions about the biology of drug targets.

«It's one thing to only try to correct splicing events, but there are a lot more opportunities in terms of drug targets,» says Gideon Dreyfuss, a biochemist at the University of Pennsylvania Perelman School of Medicine in Philadelphia who is working with the New Jersey — based pharmaceutical firm Merck to discover new compounds.

Many of the drug targets Buolamwini identified as promising during the 1990s have recently become approved therapeutics.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

«Importantly, while the overall number of new investigational cardiovascular drugs has declined, we also found a relative growth in the number of drugs targeting novel biological pathways,» Kesselheim said.

My background was in the identification of drug targets in prostate cancer, so working on developing new therapies in glaucoma was a natural progression.

They are implicated in the pathology of many diseases such as atherosclerosis, cancer, auto - immune and auto - inflammatory diseases, cancer metastasis, and hence form the biggest class of drug targets.

Poirier hopes that with further funding and support, his studies will lead to the development of drugs targeted to specific genotypes, making them safer and more effective and reducing side effects.

Our proprietary antibody discovery technology quickly characterizes every cell in complex immune systems, powering our selection of drug targets, identification of drug candidates and preclinical assessment of efficacy.

Poly (ADP - ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target...

Researchers in Sweden have just identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Biosensors for two classes of drug targets were generated, including one associated with carbon dioxide transport and pH homeostasis in the human body.

The discovery, published online in the Journal of Natural Products, shows that a compound isolated from this common plant with low branches and creamy, white fragrant flowers appears to be useful for the development of drugs targeting the parasite Plasmodium falciparum.

The quest for effective treatment against liver cancer and fatty liver disease, has made huge progress as a study led by SciLifeLab Fellow Adil Mardinoglu (KTH) has identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects.

All of these drugs target the body chemicals responsible for inflammation.