Finally, the CFC has discovered a unique population
of glia in proximity to retinal ganglion cell axons as they exit the retina.
Another
kind of glia, called microglia, are the brain's immune system.
Astrocytes are one of several
types of glia, the other cells found alongside neurons in the nervous system.
Gliosis is a non-stereotypical
response of glia associated with a pathological state that serves as an umbrella term describing various phenotypic changes.
The San Diego, California — based biotech company MediciNova recently completed a phase II
trial of a glia - inhibiting drug called ibudilast, already approved as an asthma treatment in Japan, to relieve pain and treat withdrawal in opioid abusers.
This and other research are lending credibility to the conjecture that consciousness is a
function of glia, not neurons.
«Our study is the first to demonstrates unambiguously the conversion of a specific
subtype of glia, the so - called NG2 glia, into induced neurons in living animals,» says senior study author Benedikt Berninger of Johannes Gutenberg University Mainz.
A third
class of glia, known as Schwann cells and oligodendrocytes, form insulating sleeves around neurons to keep their electric signals from diffusing.
And yet somehow the final total
number of glia always came to the same number — 280 — and they always fully infiltrated the bundle of motor neurons they needed to support.
While the hardwired motor neuron development allows for the precise control that muscle coordination requires, the flexible
development of glia makes the system more robust.
«We're showing for the first time that Müller glia in the adult mouse can give rise to new neurons after injury, and these neurons have the gene expression pattern, the morphology, the electrophysiology, and the epigenetic program to look like interneurons
instead of glia,» Reh said.
These neurospheres — free - floating
balls of glia (red), neurons (green) and stem cells — were cultivated in a lab from stem cells taken from the intestine or stomach of a mouse.
Ivan R. Minev, Pouria Moshayedi, James W. Fawcett, and Stéphanie P. Lacour
Interaction of Glia with a Compliant, Microstructured Silicone Surface Acta Biomaterialia, no. 6: 6936 — 42 (2013)
There are many more glial cells in the brain than neurons, and astrocytes are the most
abundant of the glia, so if you take a sample of brain tissue, you're fairly sure to get some astrocytes as part of the bargain.
We propose that the age - related decline in the regenerative behavior of glial cells is caused by loss of cell - to - cell communication and changes in the internal gene
expression of glia cells.
Most of the focus on HD is on the neurons, but these experiments let Benraiss study the
impact of glia on HD progression.
By blocking the
recruitment of glia, the CFC found that retinal ganglion cells as well as visual function can be protected.
Notably, this effect of pro-inflammatory agents is specific for VCAM1 and, in contrast, leads to a down - regulation of DNER in the
lysates of glia treated with TNF and IL - 1β (Fig S4).
One of those targets is the glia, and the phrase gliopathic pain has been used to point out the
importance of the glia in neuropathic pain.
In the early 2000s, researchers began exploring the
role of glia, star - shaped immune cells in the brain and spinal cord, which were traditionally thought to function as mere «housekeepers,» offering structural support for neurons and removing debris.
To conduct the study, scientists took dental pulp cells from donated baby teeth of three children with diagnoses of non-syndromic autism (part of the on - going «Tooth Fairy Project») and reprogrammed the cells to become either neurons or astrocytes, a
type of glia or support cell abundantly found in the brain.
These results demonstrate that glia may be detrimental during the initial course of glaucoma, and suggest that dampening the
responses of glia may of therapeutic value.
The transplants outcompete the mice's glia, taking their place in the developing brain until «almost
all of the glia are human,» Goldman said.
The symposium is organized by the Centre for Molecular Biology and Neuroscience (CMBN), University of Oslo, to highlight the emerging importance of the roles
of glia - neuronal interactions in brain function and disease processes.