Sentences with phrase «of haplotypes»

«De novo assembly of a haplotype - resolved diploid genome revealed.»

This process, known as amplicon resequencing, allows for each PCR amplicon to be sequenced individually, enabling both the identification of rare variants and the assignment of haplotypes.

Studies of the haplotype distribution of both mitochondrial DNA and Y chromosomes will become increasingly extensive and finely detailed, enabling us to plot the movements of ancient groups with greater precision.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.

One involves the application of haplotype resolved Hi - C to explore the structure of homolog pairing in Drosophila.

200/3: 30 Imputing genotypes of the Haplotype Reference Consortium into the haplotypes of a large case control study of age - related macular degeneration.

The graph shows the number of haplotypes found in a survey of each breed, separated into Class I and Class II DLA.

This data goes through a series of algorithms that report the likely percentage that each breed contributed to the dog's unique mix of haplotypes.

There are at least two potential causes for this non-random distribution: past population structure, and a large demographic bottleneck that resulted in the reshuffling of haplotype frequencies.

A positive correlation was identified between island area and the number of haplotypes recovered and haplotype diversity (Pearson's r = 0.80 p - value = 0.03 and r = 0.77 p - value = 0.04, respectively).

De novo assembly of a haplotype - resolved human genome.

Indeed, he notes, it's improbable that all of the previous genetic studies of red deer, including those living throughout Europe today, wouldn't have picked up any of the haplotypes he and his team identified in their new research.

Three of the haplotypes were present in more than half the asthma patients, as opposed to just a third of the healthy people, the team reports in the 9 April issue of Science.

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

In this study, researchers presented the assembly of a haplotype - resolved diploid genome without using a reference genome.

De novo assembly of a haplotype - resolved human genome Cao, H., H. Wu, R. Luo, S. Huang et al. 2015.

Here we report the assembly of a haplotype - resolved diploid genome without using a reference genome.